EFSA toxicology reference values
1R,2S,5R-isopulegyl acetate
1R,2S,5R-isopulegyl acetate (CAS 57576-09-7). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
1R,2S,5R-isopulegyl acetate is a cannabis analyte contaminant represented in the cannabis public dataset.
Substance Identity
Analyte identity and classification used for this cannabis substance page.
Contaminant Class Badge
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Dataset Snapshot
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EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| TTC Cramer Class I | 30 µg/kg bw/day | consumers | - | - |
| TTC Cramer Class I | 30 µg/kg bw/day | consumers | - | - |
| margin of safety | 19,000,000 other: | consumers | 6672a3d7-63f5-4e7a-802d-a8cba4702aa1 | - |
| Incomplete dataset | - | consumers | - | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| sub-chronic toxicity: oral | rat | oral: feed | 38 other: | - |
| Carcinogenicity_EU_PPP | - | - | - | The EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. |
| Carcinogenicity_EU_PPP | - | - | - | The Scientific Panel on Food Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217 EC and its consecutive amendments. Six substances were evaluated by the JECFA in the group of pulegone and structurally related substances. Pulegone (JECFA-no: 753) and menthofuran (JECFA-no: 758) are in Annex III of Regulation (EC) No 1334/2008 of the European Parliament and of the Council (EC, 2008) and accordingly cannot be used as flavouring substances in the EU. p-Mentha-1,4(8)-dien-3-one [FL-no: 07.127] is an alpha,beta-unsaturated ketone which was considered together with other alpha,beta-unsaturated ketones in FGE.213, in which it was concluded that additional genotoxicity data were required. The Panel considered the remaining three substances in this FGE, isopulegol [FL-no: 02.067], isopulegone [FL-no: 07.067] and isopulegyl acetate [FL-no: 09.219]). However, as there are some data indicating that isopulegone might be partly isomerised to pulegone via a minor metabolic pathway (Gordon et al., 1987; McClanahan et al., 1988), the Panel also considered data on pulegone and the metabolically related menthofuran and took into account the SCF Opinion on pulegone and menthofuran (SCF, 2002g), later revised by the European Food Safety Authority (EFSA) based on additional data (EFSA, 2005). |
| Genetic Toxicity | - | - | - | The EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. |
| Genetic Toxicity | - | - | - | The Scientific Panel on Food Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217 EC and its consecutive amendments. Six substances were evaluated by the JECFA in the group of pulegone and structurally related substances. Pulegone (JECFA-no: 753) and menthofuran (JECFA-no: 758) are in Annex III of Regulation (EC) No 1334/2008 of the European Parliament and of the Council (EC, 2008) and accordingly cannot be used as flavouring substances in the EU. p-Mentha-1,4(8)-dien-3-one [FL-no: 07.127] is an alpha,beta-unsaturated ketone which was considered together with other alpha,beta-unsaturated ketones in FGE.213, in which it was concluded that additional genotoxicity data were required. The Panel considered the remaining three substances in this FGE, isopulegol [FL-no: 02.067], isopulegone [FL-no: 07.067] and isopulegyl acetate [FL-no: 09.219]). However, as there are some data indicating that isopulegone might be partly isomerised to pulegone via a minor metabolic pathway (Gordon et al., 1987; McClanahan et al., 1988), the Panel also considered data on pulegone and the metabolically related menthofuran and took into account the SCF Opinion on pulegone and menthofuran (SCF, 2002g), later revised by the European Food Safety Authority (EFSA) based on additional data (EFSA, 2005). |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
What is the regulatory limit for 1R,2S,5R-isopulegyl acetate in cannabis?
1R,2S,5R-isopulegyl acetate does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for 1R,2S,5R-isopulegyl acetate?
1R,2S,5R-isopulegyl acetate does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for 1R,2S,5R-isopulegyl acetate?
1R,2S,5R-isopulegyl acetate has 4 EFSA OpenFoodTox reference value rows in the cannabis database, including TTC Cramer Class I, margin of safety, Incomplete dataset.
Is 1R,2S,5R-isopulegyl acetate also regulated in cosmetics or food?
1R,2S,5R-isopulegyl acetate has a cosmetics ingredient cross-reference with EU status restricted. EFSA food/toxicology context is available on this page.