EFSA toxicology reference values
Theobromine
Theobromine (CAS 83-67-0). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
Theobromine is a cannabis analyte contaminant represented in the cannabis public dataset.
Substance Identity
Analyte identity and classification used for this cannabis substance page.
Contaminant Class Badge
Color-coded cannabis class signal for scanning pesticide, metal, solvent, mycotoxin, and potency pages.
Dataset Snapshot
Compact public-data summary for page quality, state coverage, lab rows, and potency sample groups.
EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| margin of safety | 0.3 mg/kg bw/day | children | - | - |
| margin of safety | 0.3 mg/kg bw/day | adolescents | - | - |
| margin of safety | 0.3 mg/kg bw/day | lactating women | - | - |
| margin of safety | 0.3 mg/kg bw/day | pregnant women | - | - |
| margin of safety | 0.6 mg/kg bw/day | adults | - | - |
| TTC Cramer Class III | 1.5 µg/kg bw/day | consumers | - | - |
| Incomplete dataset | - | consumers | - | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| toxic effects on livestock and pets | horse | - | 0.5 other: | - |
| toxic effects on livestock and pets | swine | other: | 7 other: | - |
| toxicity to reproduction: other studies | rabbit | - | 21 mg/kg bw/day | - |
| toxic effects on livestock and pets | sheep | other: | ca.35 other: | - |
| toxic effects on livestock and pets | goat | - | 300 other: | - |
| Carcinogenicity_EU_PPP | - | - | - | The European Commission requests the European Food Safety Authority to provide a scientific opinion on the presence of theobromine in animal feed. |
| Carcinogenicity_EU_PPP | - | - | - | The Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (the Panel) is asked to advise the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel is asked to evaluate two flavouring substances in the Flavouring Group Evaluation 49 (FGE.49), using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. These two flavouring substances belong to chemical group 30, Annex I of the Commission Regulation (EC) No 1565/2000. |
| Carcinogenicity_EU_PPP | - | - | - | Following a request from the European Commission, the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) was requested to deliver a scientific opinion on the safety assessment of the flavouring substances caffeine [FL-no: 16.016] and theobromine [FL-no: 16.032] in the Flavouring Group Evaluation 49, Revision 1. |
| Genetic Toxicity | - | - | - | The Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (the Panel) is asked to advise the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel is asked to evaluate two flavouring substances in the Flavouring Group Evaluation 49 (FGE.49), using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. These two flavouring substances belong to chemical group 30, Annex I of the Commission Regulation (EC) No 1565/2000. |
| Genetic Toxicity | - | - | - | Following a request from the European Commission, the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) was requested to deliver a scientific opinion on the safety assessment of the flavouring substances caffeine [FL-no: 16.016] and theobromine [FL-no: 16.032] in the Flavouring Group Evaluation 49, Revision 1. |
| Genetic Toxicity | - | - | - | The European Commission requests the European Food Safety Authority to provide a scientific opinion on the presence of theobromine in animal feed. |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
What is the regulatory limit for Theobromine in cannabis?
Theobromine does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for Theobromine?
Theobromine does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for Theobromine?
Theobromine has 7 EFSA OpenFoodTox reference value rows in the cannabis database, including margin of safety, TTC Cramer Class III, Incomplete dataset.
Is Theobromine also regulated in cosmetics or food?
Theobromine has a cosmetics ingredient cross-reference with EU status permitted. EFSA food/toxicology context is available on this page.