Danger GHS02GHS07GHS08 NOAEL Data IARC Group 2B Prop 65 REACH Registered Cosmetic Ingredient

Ethylbenzene

Also known as: 1-Ethylbenzene, EB, EINECS 202-849-4, NCI-C56393, Ethylbenzeen (+3 more)

CAS 100-41-4

Ethylbenzene (CAS 100-41-4) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H332; H304; H373 (hearing organs). Key regulatory status: California Proposition 65, REACH registered, 47 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Ethylbenzene →

Cross-Vertical Regulatory Divergence

Ethylbenzene is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H332, H304, H373).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 14 fields

Name

Ethylbenzene

CAS Number

100-41-4

DTXSID

DTXSID3020596

Molecular Formula

C8H10

InChI Key

YNQLUTRBYVCPMQ-UHFFFAOYSA-N

Monoisotopic Mass

106.07825

Synonyms

1-EthylbenzeneEBEINECS 202-849-4NCI-C56393EthylbenzeenEtilbenzeneEtylobenzenUNII-L5I45M5G0O

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 2B	Possibly carcinogenic	2000	77

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	cancer	Yes	No	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 2; Acute Tox. 4 *; Asp. Tox. 1; STOT RE 2	H225; H332; H304; H373 (hearing organs)	GHS02; GHS07; GHS08	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Highly flammable liquid and vapour Harmful if inhaled May be harmful if swallowed Causes mild skin irritation Causes eye irritation Suspected of causing cancer May cause respiratory irritation May cause drowsiness and dizziness May be harmful if swallowed and enters airways Toxic to aquatic life
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system. Exposure above the OEL could cause lowering of consciousness.
Long-term Effects	This substance is possibly carcinogenic to humans. The substance may have effects on the kidneys and liver. This may result in impaired functions.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 7 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	100 ppm (435 mg/m³)	100	435	N
NIOSH	TWA	100 ppm (435 mg/m³)	100	435	N
NIOSH	STEL	125 ppm (545 mg/m³)	125	545	N
ACGIH	TWA	20 ppm [2021]	20	-	N
CAL/OSHA	TWA	100 ppm (435 mg/m³)	100	435	N
CAL/OSHA	STEL	125 ppm (545 mg/m³)	125	545	N
NIOSH	IDLH	800 ppm	800	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 53 records

FragranceSolventDegradant/impurityProcessing aids not otherwise specifiedCleaning agentAdhesion/cohesion promoterSolubility enhancer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 47 records

List	Keyword	Source
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
fracking; water	NY Department of Conservation	CPCat
Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - fabric treatment and dye; detected	Danish Environmental Protection Agency	Danish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
CEDI	FDA	United States Food and Drug Administration (FDA)
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - air freshener; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; Batteries; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
air; detected; emissions; Europe; Road vehicles	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Road vehicles	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Road vehicles	Danish Environmental Protection Agency	Danish EPA
detected; ground_water; MN Chemical Screening	Minnesota Pollution Control Agency	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
children; WA Children's Safe Product Act (4/2020)	State of Washington Department of Ecology	State of Washington
children	Vermont Department of Health	State of Vermont

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 85 studies

Value	Unit	Endpoint	Route	Species	Source
=276.342	mg/m3	BMCL (1 SD HEC)	inhalation	Rat	ToxValDB_ATSDR_MRLs
=669.839	mg/m3	BMCL (1 SD HEC)	inhalation	Rat	ToxValDB_ATSDR_MRLs
=2.11699	mg/L	BMCL (1SD)	inhalation	Rat	ToxValDB_ATSDR_MRLs
=8.61022	mg/L	BMCL (1SD)	inhalation	Rat	ToxValDB_ATSDR_MRLs
=0.70177	mg/L	BMDL	oral	Rat	ToxValDB_ATSDR_MRLs
=48	mg/kg bw/day	BMDL (10)	oral	Rat	ToxValDB_PPRTV_(CPHEA)
=10.68	mg/kg bw/day	BMDL (HED)	oral	Rat	ToxValDB_ATSDR_MRLs
ABinhalation=54; oral=41	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
ABinhalation=54; oral=41	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
ABinhalation=54; oral=41	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
ABinhalation=54; oral=41	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
10.12	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
54.85	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
=77	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
L5I45M5G0O	UNII	FDA UNII substance identifier	-	-	openFDA substances
L5I45M5G0O	UNII	FDA UNII substance identifier	-	-	openFDA substances
L5I45M5G0O	UNII	FDA UNII substance identifier	-	-	openFDA substances
L5I45M5G0O	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.1676	fraction	Fu	-	Human	NTP_ICE_adme_parameters
0.2568	fraction	Fu	-	Rat	NTP_ICE_adme_parameters
2B	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2B	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2B	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2	unitless	IARC group	-	-	NTP_ICE_cancer
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
6480	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
17.3582	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
55	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
57.9026	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=90	mg/kg bw/day	LEL	oral	Rat	ToxValDB_EPA_TSCA_8e
=100	ppm	LEL	oral	Rat	ToxValDB_EPA_TSCA_8e
=621	mg/kg bw/day	LEL	oral	Rat	ToxValDB_EPA_TSCA_8e
=1000	ppm	LEL	oral	Rat	ToxValDB_EPA_TSCA_8e
=34738.2	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=75.7726	mg/m3	LOAEL	inhalation	Rat (F344/N; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=250	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=325.67	mg/m3	LOAEL	inhalation	Rat	ToxValDB_ATSDR_MRLs
=325.67	mg/m3	LOAEL	inhalation	Rat (F344/N; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=408	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_IRIS
=4340	mg/m3	LOAEL	inhalation	Rat	ToxValDB_IRIS
=291	mg/kg bw/day	LOAEL (ADJ)	oral	Rat	ToxValDB_IRIS
=75.7726	mg/m3	LOAEL (HEC)	inhalation	Rat	ToxValDB_ATSDR_MRLs
=868	mg/m3	LOAEL (HEC)	inhalation	Rat	ToxValDB_PPRTV_(CPHEA)
=10	mmol/kg	LOEL	injection	Rat	ToxValDB_ECOTOX
=0.260536	mg/m3	MRL	inhalation	Human	ToxValDB_ATSDR_MRLs
=0.4	mg/kg bw/day	MRL	oral	Human	ToxValDB_ATSDR_MRLs

Showing 50 of 85 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Ethylbenzene	202-849-4	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Ethylbenzene	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ETHYLBENZENE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Ethylbenzene?

Ethylbenzene (CAS 100-41-4) is classified under EU CLP Annex VI as Flam. Liq. 2; Acute Tox. 4 *; Asp. Tox. 1; STOT RE 2 with signal word Danger. Hazard statements: H225; H332; H304; H373 (hearing organs). Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ethylbenzene?

Ethylbenzene has 85 NOAEL studies in the database. The lowest reported value is 0.05 mg/kg bw/day via oral in Human. Source: ToxValDB_PPRTV_(CPHEA).

What regulatory lists include Ethylbenzene?

Ethylbenzene appears on 32 regulatory/inventory lists including consumer_product; detected; Europe, air; detected; emissions; Europe; Vehicle - car interior, detected; Europe; Vehicle - car interior, and 29 more. Source: EPA CPDat.

Is Ethylbenzene a carcinogen according to IARC?

Ethylbenzene is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2000). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Ethylbenzene on the California Proposition 65 list?

Yes, Ethylbenzene is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for Ethylbenzene?

Occupational exposure limits for Ethylbenzene are set by OSHA, NIOSH, ACGIH. 7 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Ethylbenzene used in cosmetics?

Yes, Ethylbenzene is also indexed as a cosmetic ingredient under the name Ethylbenzene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ethylbenzene come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Ethylbenzene have different safety status in cosmetics vs industrial chemicals?

Ethylbenzene is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H332, H304, H373).

Is Ethylbenzene used outside industrial chemicals?

Ethylbenzene also appears in cosmetics, pharmaceutical databases.