Danger GHS02GHS08GHS07 NOAEL Data IARC Group 2A Prop 65 REACH Registered Cosmetic Ingredient

Styrene

Also known as: Ethenylbenzene, Phenylethylene, Vinylbenzene, Benzene, vinyl-, Bulstren K-525-19 (+15 more)

CAS 100-42-5

Styrene (CAS 100-42-5) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H361d; H332; H372 (hearing organs); H315; H319. Key regulatory status: California Proposition 65, REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Styrene (Monomer) →

Cross-Vertical Regulatory Divergence

Styrene is classified GHS Danger (H226, H361d, H332, H372, H315, H319) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Styrene

CAS Number

100-42-5

DTXSID

DTXSID2021284

Molecular Formula

C8H8

InChI Key

PPBRXRYQALVLMV-UHFFFAOYSA-N

Monoisotopic Mass

104.0626

Synonyms

EthenylbenzenePhenylethyleneVinylbenzeneBenzene, vinyl-Bulstren K-525-19EINECS 202-851-5Ethylene, phenyl-FEMA No. 3233FEMA Number 3234NCI-C02200StiroloStyreen

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 2A	Probably carcinogenic	2018	60, 82, 121

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	cancer	Yes	No	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 3; Repr. 2; Acute Tox. 4 *; STOT RE 1; Skin Irrit. 2; Eye Irrit. 2	H226; H361d; H332; H372 (hearing organs); H315; H319	GHS02; GHS08; GHS07	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Flammable liquid and vapour Harmful if inhaled Causes skin and eye irritation Suspected of causing cancer Causes damage to the central nervous system and the liver through prolonged or repeated exposure Toxic to aquatic life
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system. Exposure at high levels could cause unconsciousness.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the central nervous system. Exposure to the substance may increase noise-induced hearing loss. This substance is possibly carcinogenic to humans. See Notes.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 13 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	100 ppm	100	-	N
OSHA	CEILING	200 ppm; 600 ppm (Peak) for a single time period up to 5 min in any 3 hours	200	-	N
NIOSH	TWA	50 ppm (215 mg/m³)	50	215	N
NIOSH	STEL	100 ppm (425 mg/m³)	100	425	N
ACGIH	TWA	10 ppm [2020]	10	-	N
ACGIH	STEL	20 ppm [2020]	20	-	N
CAL/OSHA	TWA	50 ppm (215 mg/m³)	50	215	Y
CAL/OSHA	STEL	100 ppm (425 mg/m³)	100	425	Y
CAL/OSHA	CEILING	500 ppm	500	-	Y
NIOSH	IDLH	700 ppm	700	-	-
AIHA	ERPG-1	50 ppm	50	-	-
AIHA	ERPG-2	250 ppm	250	-	-
AIHA	ERPG-3	1000 ppm	1000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

FragranceViscosity modifierFlavouring and nutrientBinderMonomers

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Arts and crafts/Office supplies - fabric treatment and dye; detected	Danish Environmental Protection Agency	Danish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
CEDI	FDA	United States Food and Drug Administration (FDA)
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - air freshener; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; Batteries; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
=7.24169	mg/m3	BMC (05)	inhalation	Human	ToxValDB_Cal_OEHHA_REL_derivations
=1.27795	mg/m3	BMCL (05)	inhalation	Human	ToxValDB_TX_TCEQ
AB27	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
AB27	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
AB27	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
AB27	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
42.99	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
233.1	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
=100	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
=85	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
6.8	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
3	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
44LJ2U959V	UNII	FDA UNII substance identifier	-	-	openFDA substances
44LJ2U959V	UNII	FDA UNII substance identifier	-	-	openFDA substances
44LJ2U959V	UNII	FDA UNII substance identifier	-	-	openFDA substances
44LJ2U959V	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.1801	fraction	Fu	-	Human	NTP_ICE_adme_parameters
0.2071	fraction	Fu	-	Rat	NTP_ICE_adme_parameters
2A	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2A	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2A	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2	unitless	IARC group	-	-	NTP_ICE_cancer
0.01	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
11.4943	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
11.754	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
11.7923	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
11.8	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
12	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
19.6595	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
26.8626	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
27.2883	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
27.5863	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=1000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=2650	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=5000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=42.5982	mg/m3	LEL	inhalation	Mouse	ToxValDB_EPA_TSCA_8e
=511.178	mg/m3	LEL	inhalation	Mouse	ToxValDB_EPA_TSCA_8e
~800	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
=851.963	mg/m3	LEL	inhalation	Human	ToxValDB_NIOSH_IDLH
=1601.69	mg/m3	LEL	inhalation	Human	ToxValDB_NIOSH_IDLH
=38338.4	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=85.1963	mg/m3	LOAEL	inhalation	Human	ToxValDB_ATSDR_MRLs
=85.1963	mg/m3	LOAEL	inhalation	Human (M)	ATSDR_toxval_ATSDR_MRLs.xlsx
=100	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ATSDR_MRLs
=100	mg/kg/day	LOAEL	oral	Rat (Wistar; M)	ATSDR_toxval_ATSDR_MRLs.xlsx
=260	mg/m3	LOAEL	inhalation	Rat	ToxValDB_Health_Canada

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Styrene	202-851-5	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Styrene	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL STYRENE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0.04 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Styrene?

Styrene (CAS 100-42-5) is classified under EU CLP Annex VI as Flam. Liq. 3; Repr. 2; Acute Tox. 4 *; STOT RE 1; Skin Irrit. 2; Eye Irrit. 2 with signal word Danger. Hazard statements: H226; H361d; H332; H372 (hearing organs); H315; H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Styrene?

Styrene has 100 NOAEL studies in the database. The lowest reported value is 0 % via Ocular. Source: NTP_ICE_eye_irritation.

What regulatory lists include Styrene?

Styrene appears on 30 regulatory/inventory lists including air; detected; emissions; Europe; Other direct contact consumer goods, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe, drinking_water; Europe; manufacturing; plastic_additive, and 27 more. Source: EPA CPDat.

Is Styrene a carcinogen according to IARC?

Styrene is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 2018). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Styrene on the California Proposition 65 list?

Yes, Styrene is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for Styrene?

Occupational exposure limits for Styrene are set by OSHA, NIOSH, ACGIH. 13 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Styrene used in cosmetics?

Yes, Styrene is also indexed as a cosmetic ingredient under the name Styrene (Monomer). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Styrene come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Styrene have different safety status in cosmetics vs industrial chemicals?

Styrene is classified GHS Danger (H226, H361d, H332, H372, H315, H319) in the chemicals database but is allowed in EU cosmetics.

Is Styrene used outside industrial chemicals?

Styrene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.