Warning GHS02GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Methenamine

Also known as: Urotropine, Hexamethylenetetramine, 1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane, Aminoformaldehyde, Ammonioformaldehyde (+15 more)

CAS 100-97-0

Methenamine (CAS 100-97-0) is a chemical substance with GHS signal word Warning; key hazard signal: H228; H317. Key regulatory status: REACH registered, 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Methenamine →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Methenamine

CAS Number

100-97-0

DTXSID

DTXSID6020692

Molecular Formula

C6H12N4

InChI Key

VKYKSIONXSXAKP-UHFFFAOYSA-N

Monoisotopic Mass

140.106196

Synonyms

UrotropineHexamethylenetetramine1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decaneAminoformaldehydeAmmonioformaldehydeCaswell No. 482CystaminEINECS 202-905-8EPA Pesticide Chemical Code 045501HexaloidsHexamethylenetetraamineHexamethylenetetraminum

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Sol. 2; Skin Sens. 1	H228; H317	GHS02; GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is mildly irritating to the eyes and skin.
Long-term Effects	Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 10 records

PreservativeCatalystChemical reaction regulatorDispersing agentAdhesion/cohesion promoter

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 15 records

List	Keyword	Source
Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	European Commission	CPCat
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
Arts and crafts/Office supplies - fabric treatment and dye; detected	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe	Danish Environmental Protection Agency	Danish EPA
pharmaceutical	US International Trade Commission	CPCat
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe	Danish Environmental Protection Agency	Danish EPA
Canada; pharmaceutical	DrugBank	DrugBank
Europe; Personal care	European Commission	CosIng
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 33 of 33 studies

Value	Unit	Endpoint	Route	Species	Source
<=0.15	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
-	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=5.6	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
J50OIX95QV	UNII	FDA UNII substance identifier	-	-	openFDA substances
J50OIX95QV	UNII	FDA UNII substance identifier	-	-	openFDA substances
J50OIX95QV	UNII	FDA UNII substance identifier	-	-	openFDA substances
J50OIX95QV	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.352	fraction	Fu	-	Human	NTP_ICE_adme_parameters
>5000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=9200	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>20000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>=2000	mg/kg bw/day	LEL	dermal	Rat	ToxValDB_ECHA_IUCLID
>=20000	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=1500	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
<=2500	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
-	unitless	Model Score	-	-	NTP_ICE_endocrine
>=1.3	mg/kg bw/day	NOAEL	dermal	Rabbit	ToxValDB_ECHA_IUCLID
>=25	mg/kg bw/day	NOAEL	oral	Dog	ToxValDB_ECHA_IUCLID
>=60.65	mg/kg bw/day	NOAEL	oral	Cat	ToxValDB_ECHA_IUCLID
=80	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=100	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=732	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1130	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=1280	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=1500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1570	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=1780	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
<=2000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=2500	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
>=3000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=4000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
<=5000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=12500	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID

Showing 33 of 33 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Methenamine	202-905-8	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.16%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL METHENAMINE

ChEMBL Phase

Adverse Events

177

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E239 — ADI: 0.15 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Methenamine?

Methenamine (CAS 100-97-0) is classified under EU CLP Annex VI as Flam. Sol. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H228; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Methenamine?

Methenamine has 33 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Methenamine?

Methenamine appears on 14 regulatory/inventory lists including Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe, active_ingredient; Europe; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, and 11 more. Source: EPA CPDat.

Is Methenamine used in cosmetics?

Yes, Methenamine is also indexed as a cosmetic ingredient under the name Methenamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Methenamine come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Methenamine used outside industrial chemicals?

Methenamine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.