Danger GHS03GHS08GHS06GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Ozone

Also known as: EINECS 233-069-2, Oxygen, mol, Ozone heavy work, UNII-66H7ZZK23N, O3 (+5 more)

CAS 10028-15-6

Ozone (CAS 10028-15-6) is a chemical substance with GHS signal word Danger; key hazard signal: H270; H351; H341; H330; H370 (nervous system, respiratory system, cardiovascular system); H372 (nervous system, respiratory system); H400; H410. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for OZONE →

SOURCE noael studies public
NOAEL studies
24
SOURCE chemical inventory jurisdictions
Regulatory lists
3
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields
Name
Ozone
CAS Number
10028-15-6
DTXSID
DTXSID0021098
Molecular Formula
O3
InChI Key
CBENFWSGALASAD-UHFFFAOYSA-N
Monoisotopic Mass
47.984744
Synonyms
EINECS 233-069-2Oxygen, molOzone heavy workUNII-66H7ZZK23NO3OzonTrisauerstoff[OO2]ozonotrioxygene

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Ox. Gas 1; Carc. 2; Muta. 2; Acute Tox. 1; STOT SE 1; STOT RE 1; Aquatic Acute 1; Aquatic Chronic 1H270; H351; H341; H330; H370 (nervous system, respiratory system, cardiovascular system); H372 (nervous system, respiratory system); H400; H410GHS03; GHS08; GHS06; GHS09Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsMay cause or intensify fire; oxidizer Fatal if inhaled Causes eye irritation Causes damage to lungs if inhaled Causes damage to the lungs through prolonged or repeated exposure if inhaled
Short-term EffectsThe substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. This may result in impaired vigilance and performance. Inhalation of the gas may cause lung oedema. See Notes. The effects may be delayed. The liquid may cause frostbite.
Long-term EffectsRepeated or prolonged inhalation of the gas may cause effects on the lungs.
Routes of ExposureThe substance can be absorbed into the body by inhalation.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records
AgencyMetricValueppmmg/m3Skin
OSHATWA0.1 ppm (0.2 mg/m³)0.10.2N
NIOSHCEILING0.1 ppm (0.2 mg/m³)0.10.2N
ACGIHTWAHeavy work: 0.05 ppm (0.10 mg/m³), Moderate work: 0.08 ppm (0.16 mg/m³), Light work: 0.10 ppm (0.20 mg/m³) [1995]0.050.1N
CAL/OSHATWA0.10 ppm (0.20 mg/m³)0.10.2N
CAL/OSHASTEL0.30 ppm (0.60 mg/m³)0.30.6N
NIOSHIDLH5 ppm5--

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
PharmaceuticalNo specific technical functionBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 24 of 24 studies
ValueUnitEndpointRouteSpeciesSource
=0.024mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
66H7ZZK23NUNIIFDA UNII substance identifier--openFDA substances
66H7ZZK23NUNIIFDA UNII substance identifier--openFDA substances
66H7ZZK23NUNIIFDA UNII substance identifier--openFDA substances
66H7ZZK23NUNIIFDA UNII substance identifier--openFDA substances
0.001mg/LLC50Inhalation-NTP_ICE_acute_inhalation
0.0045mg/LLC50Inhalation-NTP_ICE_acute_inhalation
0.0094mg/LLC50Inhalation-NTP_ICE_acute_inhalation
0.028mg/LLC50Inhalation-NTP_ICE_acute_inhalation
~0.608554mg/m3LELinhalationMouseToxValDB_ECHA_IUCLID
=0.863754mg/m3LOAECinhalationRatToxValDB_ECHA_IUCLID
=0.235569mg/m3LOAELinhalationHumanToxValDB_Cal_OEHHA_REL_derivations
=0.235569mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=0.6mg/m3NOAECinhalationMouseToxValDB_ECHA_IUCLID
=0.785231mg/m3NOAECinhalationMouseToxValDB_ECHA_IUCLID
=0.863754mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=1mg/m3NOAECinhalationMouseToxValDB_ECHA_IUCLID
=1.17785mg/m3NOAECinhalationMouseToxValDB_ECHA_IUCLID
=1.57046mg/m3NOAECinhalationMouseToxValDB_ECHA_IUCLID
>1.96308mg/m3NOAECinhalationMouseToxValDB_ECHA_IUCLID
>0.981539mg/m3NOECinhalationMouseToxValDB_ECHA_IUCLID
0.981533742331288mg/m3/dayPOLY-3 lowest doseInhalationMouseNTP_ICE_cancer
1.96306748466258mg/m3/dayPOLY-3 lowest doseInhalationMouseNTP_ICE_cancer
1ppmTop doseInhalationMouseNTP_ICE_cancer

Showing 24 of 24 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredOzone233-069-2ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Ozone--

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL OZONE
ChEMBL Phase
3
Adverse Events
6
Bioactivity
0
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the GHS hazard classification for Ozone?

Ozone (CAS 10028-15-6) is classified under EU CLP Annex VI as Ox. Gas 1; Carc. 2; Muta. 2; Acute Tox. 1; STOT SE 1; STOT RE 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H270; H351; H341; H330; H370 (nervous system, respiratory system, cardiovascular system); H372 (nervous system, respiratory system); H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ozone?

Ozone has 24 NOAEL studies in the database. The lowest reported value is 0.024 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Ozone?

Ozone appears on 3 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical. Source: EPA CPDat.

What are the occupational exposure limits for Ozone?

Occupational exposure limits for Ozone are set by OSHA, NIOSH, ACGIH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Ozone used in cosmetics?

Yes, Ozone is also indexed as a cosmetic ingredient under the name OZONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ozone come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Does Ozone have different safety status in cosmetics vs industrial chemicals?

Ozone is classified GHS Danger (H270, H351, H341, H330, H370, H372, H400, H410) in the chemicals database but is allowed in EU cosmetics.

Is Ozone used outside industrial chemicals?

Ozone also appears in cosmetics, pharmaceutical, food safety databases.