What is the NOAEL for Triethanolamine?
Triethanolamine has 65 NOAEL studies in the database. The lowest reported value is 0 s via Ocular. Source: NTP ICE eye irritation.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Triethanolamine
Also known as: Ethanol, 2,2',2''-nitrilotris-, 2,2',2''-Nitrilotriethanol, Trolamine, Caswell No. 886, EINECS 203-049-8 (+12 more)
CAS 102-71-6
Triethanolamine (CAS 102-71-6) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 51 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA.
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NOAEL studies
NOAEL studies
65
SOURCE
Chemical inventory jurisdictions
Regulatory lists
51
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
22 fields
Name
Triethanolamine
CAS Number
102-71-6
Molecular Formula
C6H15NO3
InChI Key
GSEJCLTVZPLZKY-UHFFFAOYSA-N
Monoisotopic Mass
149.105193
Synonyms
Ethanol, 2,2',2''-nitrilotris-2,2',2''-NitrilotriethanolTrolamineCaswell No. 886EINECS 203-049-8EPA Pesticide Chemical Code 004208Thiofaco T-35Triethylamine, 2,2',2''-trihydroxy-Tri(hydroxyethyl)amineTris(beta-hydroxyethyl)amineUNII-9O3K93S3TK2,2',2''-nitrilotris(ethanol)
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 2000 | 77 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
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OSHA / NIOSH / ACGIH occupational exposure limits
2 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 5 mg/m³ [1990] | - | 5 | N |
| CAL/OSHA | TWA | 5 mg/m³ | - | 5 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
pH regulating agentCleaning agentSurfactant (surface active agent)DeodorizerEmulsifierSolventSolubility enhancerFragrancePigmentStabilizing agentWaterproofing agentPreservativeNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
51 records
| List | Keyword | Source |
|---|---|---|
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 65 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 42.7 | min | Breakthrough Time | Dermal | - | NTP ICE skin irritation |
| 55.3 | min | Breakthrough Time | Dermal | - | NTP ICE skin irritation |
| 1718 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 189.5 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 1936 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 4167 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| =1 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| 8 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP ICE eye irritation |
| >2000 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 9O3K93S3TK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP ICE cancer |
| 1.11 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 0.17 | %/sec | Intensity | Ocular | - | NTP ICE eye irritation |
| =5530 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =8000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =63 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB ToxRefDB |
| =63 | mg/kg bw/day | LEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =250 | mg/kg bw/day | LEL | dermal | Mouse | ToxValDB ToxRefDB |
| =250 | mg/kg bw/day | LEL | dermal | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =300 | mg/kg bw/day | LEL | dermal | Mouse | ToxValDB ToxRefDB |
| =300 | mg/kg bw/day | LEL | dermal | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =500 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB ToxRefDB |
| =500 | mg/kg bw/day | LEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =630 | mg/kg bw/day | LEL | dermal | Mouse | ToxValDB ToxRefDB |
| =630 | mg/kg bw/day | LEL | dermal | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| >250 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB ToxRefDB |
| >250 | mg/kg bw/day | LOAEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =1000 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB ToxRefDB |
| =1000 | mg/kg bw/day | LOAEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =4000 | mg/kg bw/day | LOAEL | dermal | Mouse | ToxValDB ToxRefDB |
| =4000 | mg/kg bw/day | LOAEL | dermal | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =230 | mg/m3 | LOEL | inhalation | Rat | WHO/JECFA |
| 0 | s | Lag time | Ocular | - | NTP ICE eye irritation |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| >0 | mg/kg bw/day | NEL | dermal | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =32 | mg/kg bw/day | NEL | dermal | Rat | ToxValDB ToxRefDB |
| =32 | mg/kg bw/day | NEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =100 | mg/kg bw/day | NEL | dermal | Mouse | ToxValDB ToxRefDB |
| =100 | mg/kg bw/day | NEL | dermal | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =125 | mg/kg bw/day | NEL | dermal | Rat | ToxValDB ToxRefDB |
| =125 | mg/kg bw/day | NEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =200 | mg/kg bw/day | NEL | dermal | Mouse | ToxValDB ToxRefDB |
| =200 | mg/kg bw/day | NEL | dermal | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =250 | mg/kg bw/day | NEL | dermal | Rat | ToxValDB ToxRefDB |
| =250 | mg/kg bw/day | NEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =100 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB TX TCEQ |
| 170 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
Showing 50 of 65 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2',2''-nitrilotriethanol | 203-049-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
2.5% free amine; pH of finished product must not exceed 11; must not be used with nitrosating agents
Category
pH-adjuster
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
TROLAMINE
ChEMBL Phase
2
Adverse Events
56
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Triethanolamine?
Triethanolamine appears on 23 regulatory/inventory lists including Europe; plastic_additive, active_ingredient; Europe; Pesticides, Canada; consumer_product; Substances in Products - Canada (4/2014), and 20 more. Source: EPA CPDat.
Is Triethanolamine a carcinogen according to IARC?
Triethanolamine is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 2000). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for Triethanolamine?
Occupational exposure limits for Triethanolamine are set by ACGIH, CAL/OSHA. 2 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Triethanolamine used in cosmetics?
Yes, Triethanolamine is also indexed as a cosmetic ingredient under the name Triethanolamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Triethanolamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Triethanolamine used outside industrial chemicals?
Triethanolamine also appears in cosmetics, pharmaceutical, cannabis databases.