Warning GHS07GHS09 NOAEL Data Prop 65 Cosmetic Ingredient

Resmethrin

Also known as: S.B. penick 1382, Benzofuroline, Benzyfuroline, (5-Benzyl-3-furyl) methyl-2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylate, 5-Benzyl-3-furylmethyl (+-)-cis-trans-chrysanthemate (+15 more)

CAS 10453-86-8

Resmethrin (CAS 10453-86-8) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H400; H410. Key regulatory status: California Proposition 65, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, CA Prop 65, ILO ICSC, EPA TRI.

View cosmetic safety profile for Resmethrin →

Cross-Vertical Regulatory Divergence

Resmethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

Resmethrin

CAS Number

10453-86-8

Molecular Formula

C22H26O3

InChI Key

VEMKTZHHVJILDY-UHFFFAOYSA-N

Monoisotopic Mass

338.188195

Synonyms

S.B. penick 1382BenzofurolineBenzyfuroline(5-Benzyl-3-furyl) methyl-2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylate5-Benzyl-3-furylmethyl (+-)-cis-trans-chrysanthemate5-Benzyl-3-furylmethyl (1RS)-cis,trans-chrysanthemate5-Benzyl-3-furylmethyl (1RS)-cis-trans-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate5-Benzyl-3-furylmethyl (1RS,3RS;1RS,3SR)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate5-Benzyl-3-furylmethyl(+-)-cis,trans-chrysanthemateCaswell No. 083EChrysonCrossfire

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 2 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	cancer	Yes	No	-
-	developmental	No	Yes	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4 *; Aquatic Acute 1; Aquatic Chronic 1	H302; H400; H410	GHS07; GHS09	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes and skin.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 10 records

Biocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Europe; Pesticides	European Commission	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; grain; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; grain; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; grain; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; grain; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; legumes; Pesticides; residue	USDA	United States Department of Agriculture (USDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 80 studies

Value	Unit	Endpoint	Route	Species	Source
28.15	uM	AC50	-	-	NTP ICE endocrine
30.99	uM	AC50	-	-	NTP ICE endocrine
32.3	uM	ACC	-	-	NTP ICE endocrine
45.43	uM	ACC	-	-	NTP ICE endocrine
=0.125	mg/kg bw/day	ADI	-	-	WHO/JECFA
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
96.48	uL/min/10^6 cells	Clint	-	Rat	NTP ICE adme parameters
98.96	uL/min/10^6 cells	Clint	-	Human	NTP ICE adme parameters
Z6PN6KTG4K	UNII	FDA UNII substance identifier	-	-	openFDA substances
0	fraction	Fu	-	Human	NTP ICE adme parameters
0	fraction	Fu	-	Rat	NTP ICE adme parameters
=1244	mg/kg bw	LD50	oral	Rat (Male)	NTP ICE acute oral
=1400	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1721	mg/kg bw	LD50	oral	Rat (Female)	NTP ICE acute oral
=1987	mg/kg bw	LD50	oral	Rat (Male)	NTP ICE acute oral
=25	mg/kg bw/day	LEL	oral	Rat	ToxValDB IRIS
=25	mg/kg/day	LEL	oral	-	Regulatory source
=40	mg/kg bw/day	LEL	oral	rat (sprague dawley; Sprague Dawley SD)	EPA ToxRefDB v3
=43.4	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=43.4	mg/kg bw/day	LEL	oral	mouse (cd1; Crl:CD-1(ICR)BR)	EPA ToxRefDB v3
=47	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=47	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	EPA ToxRefDB v3
=52.9	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=52.9	mg/kg bw/day	LEL	oral	mouse (cd1; Crl:CD-1(ICR)BR)	EPA ToxRefDB v3
=62.5	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=62.5	mg/kg bw/day	LEL	oral	rat (sprague dawley; Sprague Dawley SD)	EPA ToxRefDB v3
=71.3	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=71.3	mg/kg bw/day	LEL	oral	mouse (cd1; CD)	EPA ToxRefDB v3
=80	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=80	mg/kg bw/day	LEL	oral	rat	EPA ToxRefDB v3
=100	mg/kg bw/day	LEL	oral	Rabbit	ToxValDB ToxRefDB
=100	mg/kg bw/day	LEL	oral	rabbit (new zealand white; New Zealand White)	EPA ToxRefDB v3
=165.8	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=165.8	mg/kg bw/day	LEL	oral	mouse (cd1; CD)	EPA ToxRefDB v3
>300	mg/kg bw/day	LEL	oral	Dog	ToxValDB ToxRefDB
>300	mg/kg bw/day	LEL	oral	dog (beagle)	EPA ToxRefDB v3
=400.9	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=400.9	mg/kg bw/day	LEL	oral	rat (wistar; Wistar)	EPA ToxRefDB v3
=430	mg/kg bw/day	LEL	oral	Dog	ToxValDB ToxRefDB
=430	mg/kg bw/day	LEL	oral	dog (beagle; beagle)	EPA ToxRefDB v3
=84.3	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB ToxRefDB
=84.3	mg/kg bw/day	LOAEL	oral	mouse (cd1; Crl:CD-1(ICR)BR)	EPA ToxRefDB v3
=137.9	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB ToxRefDB
=137.9	mg/kg bw/day	LOAEL	oral	mouse (cd1; CD)	EPA ToxRefDB v3
=232.7	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB ToxRefDB
=232.7	mg/kg bw/day	LOAEL	oral	rat (wistar; Wistar)	EPA ToxRefDB v3
=0.247	mg/cm2	LOEL	dermal	European Rabbit	ToxValDB ECOTOX
=10	mg/kg bw/day	LOEL	injection	Dog	ToxValDB ECOTOX
=21.04	mg/kg bw/day	LOEL	oral	Rat	ToxValDB ECOTOX

Showing 50 of 80 studies

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Resmethrin	-	-

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Frequently Asked Questions

What is the GHS hazard classification for Resmethrin?

Resmethrin (CAS 10453-86-8) is classified under EU CLP Annex VI as Acute Tox. 4 *; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H302; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Resmethrin?

Resmethrin has 80 NOAEL studies in the database. The lowest reported value is 0.125 mg/kg bw/day. Source: WHO/JECFA.

What regulatory lists include Resmethrin?

Resmethrin appears on 9 regulatory/inventory lists including active_ingredient; Pesticides, Pesticides, active_ingredient; Europe; Pesticides, and 6 more. Source: EPA CPDat.

Is Resmethrin on the California Proposition 65 list?

Yes, Resmethrin is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

Is Resmethrin used in cosmetics?

Yes, Resmethrin is also indexed as a cosmetic ingredient under the name Resmethrin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Resmethrin come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, California Proposition 65, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Resmethrin have different safety status in cosmetics vs industrial chemicals?

Resmethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H400, H410).

Is Resmethrin used outside industrial chemicals?

Resmethrin also appears in cosmetics databases.