What is the NOAEL for 1,4-Dioxacycloheptadecane-5,17-dione?
1,4-Dioxacycloheptadecane-5,17-dione has 19 NOAEL studies in the database. The lowest reported value is 5 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,4-Dioxacycloheptadecane-5,17-dione
Also known as: Ethylene brassylate, 4-19-00-01936, BRN 0212344, Cyclo-1,13-ethylenedioxytridecan-1,13-dione, EINECS 203-347-8 (+6 more)
CAS 105-95-3
1,4-Dioxacycloheptadecane-5,17-dione (CAS 105-95-3) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
19
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
17 fields
Name
1,4-Dioxacycloheptadecane-5,17-dione
CAS Number
105-95-3
DTXSID
DTXSID1044774
Molecular Formula
C15H26O4
InChI Key
XRHCAGNSDHCHFJ-UHFFFAOYSA-N
Monoisotopic Mass
270.183109
Synonyms
Ethylene brassylate4-19-00-01936BRN 0212344Cyclo-1,13-ethylenedioxytridecan-1,13-dioneEINECS 203-347-8Ethyl brassylateEthylene glycol brassylate, cyclic diesterEthylene glycol, cyclic tridecanedioateFEMA No. 3543UNII-9A87HC7RODMusk T
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
FragranceDeodorizerHumectantFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 19 of 19 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 26.75 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 33.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 10 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 9A87HC7ROD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9A87HC7ROD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9A87HC7ROD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9A87HC7ROD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.869 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.985 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 12990 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 19440 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 21260 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 34750 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 35610 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6496 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 10630 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 19 of 19 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,4-dioxacycloheptadecane-5,17-dione | 203-347-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Essential Oils
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL2059298
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include 1,4-Dioxacycloheptadecane-5,17-dione?
1,4-Dioxacycloheptadecane-5,17-dione appears on 5 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), IFRA Transparency, and 2 more. Source: EPA CPDat.
Is 1,4-Dioxacycloheptadecane-5,17-dione used in cosmetics?
Yes, 1,4-Dioxacycloheptadecane-5,17-dione is also indexed as a cosmetic ingredient under the name Ethylene Brassylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,4-Dioxacycloheptadecane-5,17-dione come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,4-Dioxacycloheptadecane-5,17-dione used outside industrial chemicals?
1,4-Dioxacycloheptadecane-5,17-dione also appears in cosmetics, pharmaceutical, food safety databases.