Danger GHS06GHS09 NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

1,4-Benzenediamine

Also known as: p-Phenylenediamine, CI Developer 13, CI Oxidation Base 10, Developer 13, EINECS 203-404-7 (+15 more)

CAS 106-50-3

1,4-Benzenediamine (CAS 106-50-3) is a chemical substance with GHS signal word Danger; key hazard signal: H331; H311; H301; H319; H317; H400; H410. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for P-PHENYLENEDIAMINE →

SOURCE NOAEL studies
NOAEL studies
72
SOURCE Chemical inventory jurisdictions
Regulatory lists
8
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
1,4-Benzenediamine
CAS Number
106-50-3
Molecular Formula
C6H8N2
InChI Key
CBCKQZAAMUWICA-UHFFFAOYSA-N
Monoisotopic Mass
108.068748
Synonyms
p-PhenylenediamineCI Developer 13CI Oxidation Base 10Developer 13EINECS 203-404-7Fur Black 41866Paraphenylen-diamineParaphenylenediaminep-PhenyldiamineRodol DSantoflex ICSantoflex LC

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable198716, Sup 7

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1H331; H311; H301; H319; H317; H400; H410GHS06; GHS09Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes. Inhalation of dust may cause asthmatic reactions. See Notes. Ingestion could cause swelling of mouth and throat. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Exposure could cause death.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. The substance may have effects on the kidneys. This may result in kidney impairment.
Routes of ExposureThe substance can be absorbed into the body by inhalation, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records
AgencyMetricValueppmmg/m3Skin
OSHATWA0.1 mg/m³-0.1Y
NIOSHTWA0.1 mg/m³-0.1Y
ACGIHTWA0.1 mg/m³ [1988]-0.1Y
CAL/OSHATWA0.1 mg/m³-0.1Y
NIOSHIDLH25 mg/m³-25-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records
DyeAntioxidantHardener

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 8 records
ListKeywordSource
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
-Regulatory Toxicology and PharmacologyPublished Articles
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 72 studies
ValueUnitEndpointRouteSpeciesSource
1%-oralratRegulatory source
2%--ratRegulatory source
4mg/kg/day-oralratRegulatory source
4mg/kg bw---Regulatory source
4mg/kg-oralratRegulatory source
4mg/kg bw/day---Regulatory source
4mg/kg bw/d---Regulatory source
4mg/kg bw/d-oral-Regulatory source
4mg/kg bw/d-oralratRegulatory source
4mg/kg bw-oralratRegulatory source
4--oral-Regulatory source
<5mg/kg bw/day---Regulatory source
6.45mg/kg bw-oralratRegulatory source
8mg/kg-dermalrabbitRegulatory source
8mg/kg bw-oralratRegulatory source
8mg/kg bw/d-dermalrabbitRegulatory source
8mg/kg bw/day--ratRegulatory source
8--oral-Regulatory source
14---ratRegulatory source
16mg/kg bw-oralratRegulatory source
16mg/kg bw-dermalrabbitRegulatory source
16mg/kg bw---Regulatory source
16mg/kg bw/d---Regulatory source
16mg/kg bw/d-dermalrabbitRegulatory source
16--oral-Regulatory source
50mg/kg bw-oralratRegulatory source
50mg/kg bw-oralratRegulatory source
50--oral-Regulatory source
61--oral-Regulatory source
11.98uMAC50--NTP ICE endocrine
9.137uMACC--NTP ICE endocrine
=0.96mg/kg bw/dayBMDL (HED)oralRatToxValDB PPRTV (CPHEA)
30.2ug/mLCD54, EC200Dermal-NTP ICE skin sensitization
46.8ug/mLCD54, EC200Dermal-NTP ICE skin sensitization
0.573ug/mLCD86, EC120Dermal-NTP ICE skin sensitization
1.4ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
2ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
2.09ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
2.36ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
3.1ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
7.2ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
<9ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
21.1ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
20.83ug/mLCV70Dermal-NTP ICE skin sensitization
1.6ug/mLCV75Dermal-NTP ICE skin sensitization
20.8ug/mLCV75Dermal-NTP ICE skin sensitization
27ug/mLCV75Dermal-NTP ICE skin sensitization
36.7ug/mLCV75Dermal-NTP ICE skin sensitization
48.3ug/mLCV75Dermal-NTP ICE skin sensitization
50.3ug/mLCV75Dermal-NTP ICE skin sensitization

Showing 50 of 72 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registeredp-phenylenediamine203-404-7ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
p-Phenylenediamine--

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1443/1226-27 June 2012safe with restrictions2.0%strong sensitiser; MoS >100 for systemic; labelling required
SCCP/0976/0610 October 2006safe with restrictions2.0%strong sensitiser; labelling required

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
III/8a
Category
Hair Dyes
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL403741
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
4
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1,4-Benzenediamine?

1,4-Benzenediamine (CAS 106-50-3) is classified under EU CLP Annex VI as Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H331; H311; H301; H319; H317; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,4-Benzenediamine?

1,4-Benzenediamine has 72 NOAEL studies in the database. The lowest reported value is 0.001429 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include 1,4-Benzenediamine?

1,4-Benzenediamine appears on 4 regulatory/inventory lists including Indirect additives food contact (10/2018), Europe; Personal care - hair coloring, detected; Europe; Personal care - hair coloring, and 1 more. Source: EPA CPDat.

Is 1,4-Benzenediamine a carcinogen according to IARC?

1,4-Benzenediamine is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

What are the occupational exposure limits for 1,4-Benzenediamine?

Occupational exposure limits for 1,4-Benzenediamine are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1,4-Benzenediamine used in cosmetics?

Yes, 1,4-Benzenediamine is also indexed as a cosmetic ingredient under the name P-PHENYLENEDIAMINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,4-Benzenediamine come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,4-Benzenediamine have different safety status in cosmetics vs industrial chemicals?

1,4-Benzenediamine is classified GHS Danger (H331, H311, H301, H319, H317, H400, H410) in the chemicals database but is restricted in EU cosmetics at max III/8a.

Is 1,4-Benzenediamine used outside industrial chemicals?

1,4-Benzenediamine also appears in cosmetics, pharmaceutical databases.