Danger GHS05GHS09 NOAEL Data Cosmetic Ingredient

Dimethyldioctadecylammonium chloride

Also known as: 1-Octadecanaminium, N,N-dimethyl-N-octadecyl-, chloride, Dimethyl Dioctadecylammonium chloride, Distearyl dimethylammonium chloride, NSC 61374, UNII-OM9573ZX3X

CAS 107-64-2

Dimethyldioctadecylammonium chloride (CAS 107-64-2) is a chemical substance with GHS signal word Danger; key hazard signal: H318; H400; H410. Key regulatory status: 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ILO ICSC.

View cosmetic safety profile for Distearyldimonium Chloride →

SOURCE NOAEL studies
NOAEL studies
9
SOURCE Chemical inventory jurisdictions
Regulatory lists
11
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields
Name
Dimethyldioctadecylammonium chloride
CAS Number
107-64-2
Molecular Formula
C38H80N.ClH
InChI Key
REZZEXDLIUJMMS-UHFFFAOYSA-M
Monoisotopic Mass
586.605754
Synonyms
1-Octadecanaminium, N,N-dimethyl-N-octadecyl-, chlorideDimethyl Dioctadecylammonium chlorideDistearyl dimethylammonium chlorideNSC 61374UNII-OM9573ZX3X

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1H318; H400; H410GHS05; GHS09Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records
FieldValue
Short-term EffectsThe substance is corrosive to the eyes. The substance is irritating to the skin.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 43 records
Anti-static agentSoftener and conditionerSurfactant (surface active agent)Dispersing agentThickening agentFlow promoter

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 11 records
ListKeywordSource
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
inert_ingredient; non_food_use; PesticidesEPACPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 9 of 9 studies
ValueUnitEndpointRouteSpeciesSource
96.3unitlessDraize rabbit irritation scoreOcularRabbitNTP ICE eye irritation
OM9573ZX3XUNIIFDA UNII substance identifier--openFDA substances
1unitlessGHS ClassificationOcularRabbitNTP ICE eye irritation
0.03%/secIntensityOcular-NTP ICE eye irritation
=1.130e+4mg/kg bwLD50oralRat (Male)NTP ICE acute oral
=1.300e+4mg/kg bwLD50oralRat (Female)NTP ICE acute oral
90sLag timeOcular-NTP ICE eye irritation
=100mg/kg bw/dayNOAELoralRatToxValDB HESS
1%Plateau levelOcular-NTP ICE eye irritation

Showing 9 of 9 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
conditioning agent
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for Dimethyldioctadecylammonium chloride?

Dimethyldioctadecylammonium chloride (CAS 107-64-2) is classified under EU CLP Annex VI as Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H318; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Dimethyldioctadecylammonium chloride?

Dimethyldioctadecylammonium chloride has 9 NOAEL studies in the database. The lowest reported value is 96.3 unitless via Ocular in Rabbit. Source: NTP ICE eye irritation.

What regulatory lists include Dimethyldioctadecylammonium chloride?

Dimethyldioctadecylammonium chloride appears on 2 regulatory/inventory lists including active_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.

Is Dimethyldioctadecylammonium chloride used in cosmetics?

Yes, Dimethyldioctadecylammonium chloride is also indexed as a cosmetic ingredient under the name Distearyldimonium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Dimethyldioctadecylammonium chloride come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Dimethyldioctadecylammonium chloride have different safety status in cosmetics vs industrial chemicals?

Dimethyldioctadecylammonium chloride is classified GHS Danger (H318, H400, H410) in the chemicals database but is allowed in EU cosmetics.

Is Dimethyldioctadecylammonium chloride used outside industrial chemicals?

Dimethyldioctadecylammonium chloride also appears in cosmetics databases.