Danger GHS02GHS08GHS07 NOAEL Data IARC Group 2B Prop 65 REACH Registered Cosmetic Ingredient

4-Methyl-2-pentanone

Also known as: MIBK, Methyl isobutyl ketone, 4-01-00-03305, BRN 0605399, Caswell No. 574AA (+15 more)

CAS 108-10-1

4-Methyl-2-pentanone (CAS 108-10-1) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H351; H332; H336; H319. Key regulatory status: California Proposition 65, REACH registered, 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for MIBK (Methyl Isobutyl Ketone) →

SOURCE noael studies public
NOAEL studies
51
SOURCE chemical inventory jurisdictions
Regulatory lists
17
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
4-Methyl-2-pentanone
CAS Number
108-10-1
DTXSID
DTXSID5021889
Molecular Formula
C6H12O
InChI Key
NTIZESTWPVYFNL-UHFFFAOYSA-N
Monoisotopic Mass
100.088815
Synonyms
MIBKMethyl isobutyl ketone4-01-00-03305BRN 0605399Caswell No. 574AAEINECS 203-550-1EPA Pesticide Chemical Code 044105FEMA No. 2731FEMA Number 2731HexanoneIsohexanoneKetone, isobutyl methyl

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 2BPossibly carcinogenic2011101

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 2 records
ChemicalToxicity TypeCancerDevelopmentalListed
-cancerYesNo-
-developmentalNoYes-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Flam. Liq. 2; Carc. 2; Acute Tox. 4; STOT SE 3; Eye Irrit. 2H225; H351; H332; H336; H319GHS02; GHS08; GHS07Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance and the vapour are irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system at high concentrations. This may result in narcosis.
Long-term EffectsRepeated or prolonged contact with skin may cause dermatitis.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its vapour and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records
AgencyMetricValueppmmg/m3Skin
OSHATWA100 ppm (410 mg/m³)100410N
NIOSHTWA50 ppm (205 mg/m³)50205N
NIOSHSTEL75 ppm (300 mg/m³)75300N
CAL/OSHATWA50 ppm (205 mg/m³)50205N
CAL/OSHASTEL75 ppm (300 mg/m³)75300N
NIOSHIDLH500 ppm500--

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 21 records
SolventFragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 17 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
consumer_productP&GProctor & Gamble
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
EuropeEuropean CommissionFl@vis
air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
OEHHA Proposition 65 (3/2019)STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCYOEHHA Proposition 65 List
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
OEHHA Proposition 65 (1/2023)California Office of Environmental Health Hazard AssessmentOEHHA Proposition 65 List
OEHHA Proposition 65 (3/2019)STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCYOEHHA Proposition 65 List
OEHHA Proposition 65 (1/2023)California Office of Environmental Health Hazard AssessmentOEHHA Proposition 65 List
detected; drinking_water; MN Chemical ScreeningUSGSState of Minnesota
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; EuropeDanish Environmental Protection AgencyDanish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 51 studies
ValueUnitEndpointRouteSpeciesSource
LCcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
LCcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
LCcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
LCcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
=83mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
4.8unitlessDraize rabbit irritation scoreOcularRabbitNTP_ICE_eye_irritation
3unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
U5T7B88CNPUNIIFDA UNII substance identifier--openFDA substances
U5T7B88CNPUNIIFDA UNII substance identifier--openFDA substances
U5T7B88CNPUNIIFDA UNII substance identifier--openFDA substances
U5T7B88CNPUNIIFDA UNII substance identifier--openFDA substances
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2unitlessIARC group--NTP_ICE_cancer
0.25%/secIntensityOcular-NTP_ICE_eye_irritation
100mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=49159mg/m3LELinhalationHumanToxValDB_DOE_Protective_Action_Criteria
=3073mg/m3LOAEL (HEC)inhalationRatToxValDB_IRIS
-sLag timeOcular-NTP_ICE_eye_irritation
=4096.58mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=25mg/kg bw/dayNOAELoralRatToxValDB_DOE_Wildlife_Benchmarks
=50mg/kg bw/dayNOAELoralRatToxValDB_Mass._ORSG
=414mg/m3NOAEL-Rat; MouseINCHEM_WHO_ehc_ehc_ehc117
=414mg/m3NOAEL-Rat; MouseINCHEM_WHO_ehc_ehc_ehc117
681mg/kg bw/dayNOAELoralratCOSMOS_DB
1362mg/kg bw/dayNOAELoralratCOSMOS_DB
=1026mg/m3NOAEL (HEC)inhalationRatToxValDB_IRIS
=1026mg/m^3NOAEL (HEC)inhalation-EPA_IRIS_iris_rfc_systems.csv
=50mg/kg bw/dayNOELoralRatINCHEM_WHO_ehc_ehc_ehc117
=50mg/kg bw/dayNOELoralRatINCHEM_WHO_ehc_ehc_ehc117
=1000mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
7373.81595092025mg/m3/dayPOLY-3 lowest doseInhalationRatNTP_ICE_cancer
32%Plateau levelOcular-NTP_ICE_eye_irritation
=0.8mg/m3RfCinhalationHumanToxValDB_RSL
=3mg/m3RfCinhalationHumanToxValDB_Alaska_DEC
=3mg/m3RfCinhalationHumanToxValDB_Alaska_DEC
=3mg/m^3RfCinhalation-EPA_IRIS_iris_rfc_systems.csv
=0.05mg/kg bw/dayRfDoralHumanToxValDB_Mass._ORSG
=0.064mg/kg bw/dayRfDdermalHumanToxValDB_Alaska_DEC
=0.064mg/kg bw/dayRfDdermalHumanToxValDB_Alaska_DEC
=0.08mg/kg bw/dayRfDoralHumanToxValDB_Alaska_DEC
=0.08mg/kg bw/dayRfDoralHumanToxValDB_Alaska_DEC
=0.8mg/kg bw/dayRfDoralHumanToxValDB_RSL
=0.857mg/kg bw/dayRfDinhalationHumanToxValDB_Alaska_DEC
=0.857mg/kg bw/dayRfDinhalationHumanToxValDB_Alaska_DEC

Showing 50 of 51 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered4-methylpentan-2-one203-550-1ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Methyl isobutyl ketone--

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL METHYL ISOBUTYL KETONE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 4-Methyl-2-pentanone?

4-Methyl-2-pentanone (CAS 108-10-1) is classified under EU CLP Annex VI as Flam. Liq. 2; Carc. 2; Acute Tox. 4; STOT SE 3; Eye Irrit. 2 with signal word Danger. Hazard statements: H225; H351; H332; H336; H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 4-Methyl-2-pentanone?

4-Methyl-2-pentanone has 51 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.

What regulatory lists include 4-Methyl-2-pentanone?

4-Methyl-2-pentanone appears on 14 regulatory/inventory lists including IFRA Transparency, consumer_product, detected; Europe; Other direct contact consumer goods, and 11 more. Source: EPA CPDat.

Is 4-Methyl-2-pentanone a carcinogen according to IARC?

4-Methyl-2-pentanone is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2011). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is 4-Methyl-2-pentanone on the California Proposition 65 list?

Yes, 4-Methyl-2-pentanone is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for 4-Methyl-2-pentanone?

Occupational exposure limits for 4-Methyl-2-pentanone are set by OSHA, NIOSH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 4-Methyl-2-pentanone used in cosmetics?

Yes, 4-Methyl-2-pentanone is also indexed as a cosmetic ingredient under the name MIBK (Methyl Isobutyl Ketone). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Methyl-2-pentanone come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-Methyl-2-pentanone have different safety status in cosmetics vs industrial chemicals?

4-Methyl-2-pentanone is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H351, H332, H336, H319).

Is 4-Methyl-2-pentanone used outside industrial chemicals?

4-Methyl-2-pentanone also appears in cosmetics, pharmaceutical, cannabis databases.