Danger GHS07GHS08GHS09 NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

Resorcinol

Also known as: 1,3-Benzenediol, 4-06-00-05658, Benzene, m-dihydroxy-, Benzene, 1,3-dihydroxy-, BRN 0906905 (+15 more)

CAS 108-46-3

Resorcinol (CAS 108-46-3) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H370 (nervous system); H315; H319; H317; H400. Key regulatory status: REACH registered, 28 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Resorcinol Cosmetic →

SOURCE NOAEL studies
NOAEL studies
100
SOURCE Chemical inventory jurisdictions
Regulatory lists
28
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Resorcinol
CAS Number
108-46-3
DTXSID
DTXSID2021238
Molecular Formula
C6H6O2
InChI Key
GHMLBKRAJCXXBS-UHFFFAOYSA-N
Monoisotopic Mass
110.036779
Synonyms
1,3-Benzenediol4-06-00-05658Benzene, m-dihydroxy-Benzene, 1,3-dihydroxy-BRN 0906905Caswell No. 723Dihydroxybenzolm-DioxybenzeneEINECS 203-585-2EPA Pesticide Chemical Code 071401FEMA No. 35893-Hydroxycyclohexadien-1-one

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable199815, Sup 7, 71

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4; STOT SE 1; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1B; Aquatic Acute 1H302; H370 (nervous system); H315; H319; H317; H400GHS07; GHS08; GHS09Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization in rare cases.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records
AgencyMetricValueppmmg/m3Skin
NIOSHTWA10 ppm (45 mg/m³)1045N
NIOSHSTEL20 ppm (90 mg/m³)2090N
ACGIHTWA10 ppm [1992]10-N
ACGIHSTEL20 ppm [1992]20-N
CAL/OSHATWA10 ppm (45 mg/m³)1045N
CAL/OSHASTEL20 ppm (90 mg/m³)2090N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 25 records
AntioxidantFragranceDeodorizerDyePharmaceuticalFlame retardantUV stabilizerStabilizing agentFlavouring and nutrientConductive agentAdhesion/cohesion promoterBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 28 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
EuropeEuropean CommissionFl@vis
inert_ingredient; non_food_use; PesticidesEPACPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
Australia; Food and drug - smoking-related productsNew Zealand ESRCPCat
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - permanentDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - permanentDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; plastic_additiveEuropean Chemicals AgencyEuropean Chemicals Agency (ECHA)
-Regulatory Toxicology and PharmacologyPublished Articles
IFRA TransparencyIFRAIFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
Canada; pharmaceuticalDrugBankDrugBank
-Danish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
-----Regulatory source
2----Regulatory source
80mg/kg bw/day-oralratRegulatory source
80--oral-Regulatory source
101mg/kg bw/d--humanRegulatory source
101mg/kg/d-oralratRegulatory source
101mg/kg bw/d---Regulatory source
101----Regulatory source
112mg/kg bw-oralmouseRegulatory source
112mg/kg bw-oralmouseRegulatory source
130mg/kg/day-oralratRegulatory source
130mg/kg bw/d-oralratRegulatory source
130mg/kg bw/d-oralratRegulatory source
173mg/kg/d---Regulatory source
173----Regulatory source
173----Regulatory source
173----Regulatory source
177mg/kg/d---Regulatory source
177----Regulatory source
177----Regulatory source
177----Regulatory source
177mg/kg/d---Regulatory source
177----Regulatory source
177----Regulatory source
177----Regulatory source
~186mg/kg bw/day-oralratRegulatory source
~186mg/kg bw/day---Regulatory source
~233mg/kg bw/day---Regulatory source
~233mg/kg bw/day---Regulatory source
304mg/kg bw/d-oral-Regulatory source
304mg/kg bw/d-oral-Regulatory source
520--oral-Regulatory source
1992---ratRegulatory source
32.084017601991uMAC50--NTP ICE endocrine
28.6225831546908uMACC--NTP ICE endocrine
=0.12mg/kg bw/dayADI-ConsumersEFSA
=0.12mg/kg bw/dayADI-ConsumersEFSA
201ug/mLCD54, EC200Dermal-NTP ICE skin sensitization
201.5ug/mLCD54, EC200Dermal-NTP ICE skin sensitization
4.75ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
29.603ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
172.97ug/mLCV70Dermal-NTP ICE skin sensitization
613.4ug/mLCV75Dermal-NTP ICE skin sensitization
14.48uL/min/10^6 cellsClint-HumanNTP ICE adme parameters
=132.8mg/m3DNEL localinhalationHumanToxValDB GESTIS DNEL
=5.6mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
-1%Depletion CysDermal-NTP ICE skin sensitization
1.6%Depletion CysDermal-NTP ICE skin sensitization
-0.8%Depletion LysDermal-NTP ICE skin sensitization
13.1%Depletion LysDermal-NTP ICE skin sensitization

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registeredresorcinol; 1,3-benzenediol203-585-2ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 3 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1619/2030-31 March 2021safe with restrictions1.25% hair/eyelashes; 0.5% lotions/shampoosmoderate skin sensitiser; potential endocrine disrupting properties
SCCS/1390/1023 March 2010safe with restrictions1.25%sensitising potential; use with caution in persons with thyroid conditions
SCCP/1117/0715 April 2008safe with restrictions1.25%sensitising potential; thyroid effects at high doses

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
1.25% in oxidative hair dye formulations
Category
colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed RESORCINOL
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
15
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Resorcinol?

Resorcinol (CAS 108-46-3) is classified under EU CLP Annex VI as Acute Tox. 4; STOT SE 1; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1B; Aquatic Acute 1 with signal word Danger. Hazard statements: H302; H370 (nervous system); H315; H319; H317; H400. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Resorcinol?

Resorcinol has 100 NOAEL studies in the database. The lowest reported value is -1 % via Dermal. Source: NTP ICE skin sensitization.

What regulatory lists include Resorcinol?

Resorcinol appears on 13 regulatory/inventory lists including Europe; Personal care; restricted, Europe, inert_ingredient; non_food_use; Pesticides, and 10 more. Source: EPA CPDat.

Is Resorcinol a carcinogen according to IARC?

Resorcinol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

What are the occupational exposure limits for Resorcinol?

Occupational exposure limits for Resorcinol are set by NIOSH, ACGIH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Resorcinol used in cosmetics?

Yes, Resorcinol is also indexed as a cosmetic ingredient under the name Resorcinol Cosmetic. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Resorcinol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Resorcinol have different safety status in cosmetics vs industrial chemicals?

Resorcinol is classified GHS Danger (H302, H370, H315, H319, H317, H400) in the chemicals database but is restricted in EU cosmetics at max 1.25% in oxidative hair dye formulations.

Is Resorcinol used outside industrial chemicals?

Resorcinol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.