Also known as: EINECS 203-604-4, Fleet-X, UNII-887L18KQ6X, s-trimethylbenzene
CAS 108-67-8
1,3,5-Trimethylbenzene (CAS 108-67-8) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H335; H411. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; STOT SE 3; Aquatic Chronic 2 | H226; H335; H411 | GHS02; GHS07; GHS09 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. Repeated or prolonged inhalation may cause effects on the lungs. This may result in chronic bronchitis. The substance may have effects on the central nervous system and blood. See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| detected; ground_water; MN Chemical Screening | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| IFRA Transparency | IFRA | IFRA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =18.15 | mg/m3 | BMCL (1SD HEC) | inhalation | Rat | ToxValDB IRIS |
| =18.15 | mg/m^3 | BMCL 1SD (HEC) | inhalation | - | Regulatory source |
| =3.5 | mg/kg bw/day | BMDL (1SD HED) | oral | Rat | ToxValDB IRIS |
| =3.5 | mg/kg/day | BMDL 1SD (HED) | oral | - | Regulatory source |
| =100 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| 887L18KQ6X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 24 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =2551 | mg/m3 | LEL | inhalation | Mouse | ECHA |
| 300 | ppm | LOEL | Inhalation | Rat | NTP ICE dart |
| 600 | ppm | LOEL | Inhalation | Rat | NTP ICE dart |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =491.6 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| =1229 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| =5900 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| =143 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB Cal OEHHA |
| =600 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =0.007 | mg/m3 | RfC | inhalation | Human | ToxValDB Alaska DEC |
| =0.06 | mg/m3 | RfC | inhalation | Human | ToxValDB IRIS |
| =0.06 | mg/m^3 | RfC | inhalation | - | Regulatory source |
| =0.2 | mg/m3 | RfC | inhalation | Human | ToxValDB IRIS |
| =0.2 | mg/m^3 | RfC | inhalation | - | Regulatory source |
| =0.2 | mg/m^3 | RfC | inhalation | - | Regulatory source |
| =0.00171 | mg/kg bw/day | RfD | inhalation | Human | ToxValDB Alaska DEC |
| =0.01 | mg/kg bw/day | RfD | oral | Human | ToxValDB IRIS |
| =0.01 | mg/kg/day | RfD | oral | - | Regulatory source |
| =0.04 | mg/kg bw/day | RfD | dermal | Human | ToxValDB Alaska DEC |
| =0.04 | mg/kg bw/day | RfD | oral | Human | ToxValDB IRIS |
| =0.04 | mg/kg/day | RfD | oral | - | Regulatory source |
| =0.04 | mg/kg/day | RfD | oral | - | Regulatory source |
| =0.05 | mg/kg bw/day | RfD | oral | Human | ToxValDB Alaska DEC |
Showing 30 of 30 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Mesitylene | 203-604-4 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
1,3,5-Trimethylbenzene (CAS 108-67-8) is classified under EU CLP Annex VI as Flam. Liq. 3; STOT SE 3; Aquatic Chronic 2 with signal word Warning. Hazard statements: H226; H335; H411. Source: EU CLP Annex VI (ECHA).
1,3,5-Trimethylbenzene has 30 NOAEL studies in the database. The lowest reported value is 0.00171 mg/kg bw/day via inhalation in Human. Source: ToxValDB Alaska DEC.
1,3,5-Trimethylbenzene appears on 5 regulatory/inventory lists including detected; ground_water; MN Chemical Screening, detected; drinking_water; MN Chemical Screening, IFRA Transparency, and 2 more. Source: EPA CPDat.
Yes, 1,3,5-Trimethylbenzene is also indexed as a cosmetic ingredient under the name Mesitylene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
1,3,5-Trimethylbenzene also appears in cosmetics, pharmaceutical databases.