Also known as: Methyl cellosolve acetate, Ethanol, 2-methoxy-, 1-acetate, Acetic acid 2-methoxyethyl ester, BRN 1700761, Ethylene glycol monomethyl ether acetate (+14 more)
CAS 110-49-6
2-Methoxyethyl acetate (CAS 110-49-6) is a chemical substance with GHS signal word Danger; key hazard signal: H360FD; H332; H312; H302. Key regulatory status: SVHC Candidate List, California Proposition 65, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA SVHC, CA Prop 65, ILO ICSC, OSHA.
2-Methoxyethyl acetate is prohibited in EU cosmetics but has active industrial GHS classifications (H360FD, H332, H312, H302).
CAS, identifiers, formula, and alternate names for the matched substance record.
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| 2-methoxyethyl acetate | Toxic for reproduction (Article 57c) | 16-Jul-2019 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | developmental, male | No | Yes | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 1B; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 * | H360FD; H332; H312; H302 | GHS08; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The vapour is mildly irritating to the eyes. The substance may cause effects on the bone marrow and central nervous system. The substance may cause effects on the blood at high levels. This may result in lesions of blood cells and kidney impairment. Exposure far above the OEL could cause unconsciousness. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the bone marrow and blood. This may result in lesions of blood cells and kidney impairment. May cause toxicity to human reproduction or development. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 25 ppm (120 mg/m³) | 25 | 120 | Y |
| NIOSH | TWA | 0.1 ppm (0.5 mg/m³) | 0.1 | 0.5 | Y |
| ACGIH | TWA | 0.1 ppm [2005] | 0.1 | - | Y |
| CAL/OSHA | TWA | 5 ppm (24 mg/m³) | 5 | 24 | N |
| NIOSH | IDLH | 200 ppm | 200 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| consumer_product | P&G | Proctor & Gamble |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.73 | mg/m3 | BMCL (10 HEC) | inhalation | Rabbit | ToxValDB_PPRTV_(CPHEA) |
| =1.64 | mg/kg bw/day | BMDL (05) | oral | Monkey | ToxValDB_PPRTV_(CPHEA) |
| ABoral=98 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| ABoral=98 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| ABoral=98 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| ABoral=98 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| ABdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| I62493E04O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I62493E04O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I62493E04O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I62493E04O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1250 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2900 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3930 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =72474 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =144.948 | mg/m3 | NOAEL | inhalation | Rabbit | ToxValDB_Cal_OEHHA_REL_derivations |
| =0.03 | mg/m3 | RfC | inhalation | Human | ToxValDB_EPA_HWIR |
| =0.001 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.01 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.008 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.03 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 24 of 24 studies
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
2-Methoxyethyl acetate (CAS 110-49-6) is classified under EU CLP Annex VI as Repr. 1B; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 * with signal word Danger. Hazard statements: H360FD; H332; H312; H302. Source: EU CLP Annex VI (ECHA).
2-Methoxyethyl acetate has 24 NOAEL studies in the database. The lowest reported value is 0.73 mg/m3 via inhalation in Rabbit. Source: ToxValDB_PPRTV_(CPHEA).
2-Methoxyethyl acetate appears on 4 regulatory/inventory lists including Cons electronics mech appliances and machinery; Europe, OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023), and 1 more. Source: EPA CPDat.
Yes, 2-Methoxyethyl acetate is listed under California Proposition 65 for developmental, male. Source: California OEHHA Proposition 65.
Yes, 2-Methoxyethyl acetate is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Toxic for reproduction (Article 57c). Source: ECHA SVHC Candidate List.
Occupational exposure limits for 2-Methoxyethyl acetate are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, 2-Methoxyethyl acetate is also indexed as a cosmetic ingredient under the name Methoxyethanol Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
2-Methoxyethyl acetate is prohibited in EU cosmetics but has active industrial GHS classifications (H360FD, H332, H312, H302).
2-Methoxyethyl acetate also appears in cosmetics databases.