Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Diisopropanolamine

Also known as: 2-Propanol, 1,1'-iminobis-, 3-04-00-00761, BRN 0605363, Dipropyl-2,2'-dihydroxy-amine, EINECS 203-820-9 (+1 more)

CAS 110-97-4

Diisopropanolamine (CAS 110-97-4) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Diisopropanolamine →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields

Name

Diisopropanolamine

CAS Number

110-97-4

DTXSID

DTXSID8020179

Molecular Formula

C6H15NO2

InChI Key

LVTYICIALWPMFW-UHFFFAOYSA-N

Monoisotopic Mass

133.110279

Synonyms

2-Propanol, 1,1'-iminobis-3-04-00-00761BRN 0605363Dipropyl-2,2'-dihydroxy-amineEINECS 203-820-9UNII-0W44HYL8T5

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Eye Irrit. 2	H319	GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is corrosive to the eyes, skin and respiratory tract. Inhalation of the aerosol may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 28 records

pH regulating agentStabilizing agentCleaning agentEmulsifierChelating agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
Europe; plastic_additive	European Chemicals Agency	European Chemicals Agency (ECHA)
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 18 of 18 studies

Value	Unit	Endpoint	Route	Species	Source
22.2936425539403	uM	AC50	-	-	NTP_ICE_endocrine
15.3802522623146	uM	ACC	-	-	NTP_ICE_endocrine
=6.4	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
9.7	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
0W44HYL8T5	UNII	FDA UNII substance identifier	-	-	openFDA substances
0W44HYL8T5	UNII	FDA UNII substance identifier	-	-	openFDA substances
0W44HYL8T5	UNII	FDA UNII substance identifier	-	-	openFDA substances
0W44HYL8T5	UNII	FDA UNII substance identifier	-	-	openFDA substances
2	unitless	GHS Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
0.24	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
=4765	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=7600	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
-	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.0651	unitless	Model Score	-	-	NTP_ICE_endocrine
=100	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
43.1	%	Plateau level	Ocular	-	NTP_ICE_eye_irritation

Showing 18 of 18 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	1,1'-iminodipropan-2-ol	203-820-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DIISOPROPANOLAMINE

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Diisopropanolamine?

Diisopropanolamine (CAS 110-97-4) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Diisopropanolamine?

Diisopropanolamine has 18 NOAEL studies in the database. The lowest reported value is 6.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Diisopropanolamine?

Diisopropanolamine appears on 4 regulatory/inventory lists including Europe; plastic_additive, inert_ingredient; non_food_use; Pesticides, CEDI, and 1 more. Source: EPA CPDat.

Is Diisopropanolamine used in cosmetics?

Yes, Diisopropanolamine is also indexed as a cosmetic ingredient under the name Diisopropanolamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Diisopropanolamine come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is Diisopropanolamine used outside industrial chemicals?

Diisopropanolamine also appears in cosmetics, pharmaceutical databases.