What is the NOAEL for (E)-Squalene?
(E)-Squalene has 6 NOAEL studies in the database. The lowest reported value is 27.17 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(E)-Squalene
Also known as: 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (6E,10E,14E,18E)-, EINECS 203-826-1, Super Squalene, 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene, (all-E)-, UNII-7QWM220FJH (+3 more)
CAS 111-02-4
(E)-Squalene (CAS 111-02-4) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
(E)-Squalene is classified GHS Danger (H304) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
(E)-Squalene
CAS Number
111-02-4
DTXSID
DTXSID0026044
Molecular Formula
C30H50
InChI Key
YYGNTYWPHWGJRM-AAJYLUCBSA-N
Monoisotopic Mass
410.391252
Synonyms
2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (6E,10E,14E,18E)-EINECS 203-826-1Super Squalene2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene, (all-E)-UNII-7QWM220FJH(14E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene(6Z,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene(all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =27.17 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 7QWM220FJH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7QWM220FJH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7QWM220FJH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7QWM220FJH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ~660 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene | 203-826-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SQUALENE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
4
Frequently Asked Questions
What regulatory lists include (E)-Squalene?
(E)-Squalene appears on 1 regulatory/inventory list including detected; Europe; Other direct contact consumer goods. Source: EPA CPDat.
Is (E)-Squalene used in cosmetics?
Yes, (E)-Squalene is also indexed as a cosmetic ingredient under the name Squalene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (E)-Squalene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does (E)-Squalene have different safety status in cosmetics vs industrial chemicals?
(E)-Squalene is classified GHS Danger (H304) in the chemicals database but is allowed in EU cosmetics.
Is (E)-Squalene used outside industrial chemicals?
(E)-Squalene also appears in cosmetics, pharmaceutical databases.