What is the GHS hazard classification for Heptanoic acid?
Heptanoic acid (CAS 111-14-8) is classified under EU CLP Annex VI as Skin Corr. 1B with signal word Danger. Hazard statements: H314. Source: EU CLP Annex VI (ECHA).
Danger
GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
Heptanoic acid
Also known as: n-Heptanoic acid, 4-02-00-00958, BRN 1744723, EINECS 203-838-7, FEMA No. 3348 (+14 more)
CAS 111-14-8
Heptanoic acid (CAS 111-14-8) is a chemical substance with GHS signal word Danger; key hazard signal: H314. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Heptanoic acid is classified GHS Danger (H314) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
13
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Heptanoic acid
CAS Number
111-14-8
DTXSID
DTXSID2021600
Molecular Formula
C7H14O2
InChI Key
MNWFXJYAOYHMED-UHFFFAOYSA-N
Monoisotopic Mass
130.09938
Synonyms
n-Heptanoic acid4-02-00-00958BRN 1744723EINECS 203-838-7FEMA No. 3348Hexacid C-7UNII-THE3YNP39DArtec ultra conditioning teat dip1-HexanecarboxylateEnanthateEnanthylateHeptanoate
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Skin Corr. 1B | H314 | GHS05 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Causes severe skin burns and eye damage Harmful if inhaled May cause respiratory irritation |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. See Notes. The effects may be delayed. Medical observation is indicated. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
FragrancepH regulating agentFlavouring and nutrientNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
13 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =98.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| THE3YNP39D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| THE3YNP39D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| THE3YNP39D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| THE3YNP39D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =7000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =8370 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >1000 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =3500 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg | LOEL | dermal | Mouse | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| <200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | NOAEL | dermal | Rabbit | ToxValDB_HPVIS |
| =1000 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =1750 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <=2000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| 64.5 | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
Showing 18 of 18 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Heptanoic acid | 203-838-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
HEPTANOATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Heptanoic acid?
Heptanoic acid has 18 NOAEL studies in the database. The lowest reported value is 98.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include Heptanoic acid?
Heptanoic acid appears on 11 regulatory/inventory lists including pharmaceutical, artificial_saliva; detected; emissions; Europe; Toys and children's products, Australia; Food and drug - smoking-related products, and 8 more. Source: EPA CPDat.
Is Heptanoic acid used in cosmetics?
Yes, Heptanoic acid is also indexed as a cosmetic ingredient under the name Heptanoic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Heptanoic acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Heptanoic acid have different safety status in cosmetics vs industrial chemicals?
Heptanoic acid is classified GHS Danger (H314) in the chemicals database but is allowed in EU cosmetics.
Is Heptanoic acid used outside industrial chemicals?
Heptanoic acid also appears in cosmetics, pharmaceutical, cannabis databases.