Also known as: Ethanol, 2,2'-iminobis-, 2,2'-Iminobisethanol, 2-(2-Hydroxy-ethylamino)-ethanol, 4-04-00-01514, BRN 0605315 (+14 more)
CAS 111-42-2
Diethanolamine (CAS 111-42-2) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H373 **; H315; H318. Key regulatory status: California Proposition 65, REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
View cosmetic safety profile for Diethanolamine (restrictions) →
Diethanolamine is classified GHS Danger (H302, H373, H315, H318) in the chemicals database but is allowed in EU cosmetics at max 10%.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2011 | 77, 101 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; STOT RE 2 *; Skin Irrit. 2; Eye Dam. 1 | H302; H373 **; H315; H318 | GHS07; GHS08; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the liver and kidneys. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 3 ppm (15 mg/m³) | 3 | 15 | N |
| ACGIH | TWA | 1 mg/m³ (inhalable fraction and vapor) [2008] | - | 1 | Y |
| CAL/OSHA | TWA | 0.46 ppm (2 mg/m³) | 0.46 | 2 | Y |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| banned; Europe; Personal care | European Commission | CosIng |
| agricultural; detected; Pesticides; surface_water | USGS | United States Geological Survey (USGS) |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| consumer_product | P&G | Proctor & Gamble |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 10 | mg/kg/d | - | dermal | mouse | Regulatory source |
| 250 | mg/kg | - | - | rat | Regulatory source |
| =0.63 | mg/m3 | BMCL (10 HEC) | inhalation | Rat | ToxValDB PPRTV (CPHEA) |
| =12.9 | mg/m3 | BMDL (10 HEC) | inhalation | Rat | ToxValDB TX TCEQ |
| =6.85 | mg/kg bw/day | BMDL (1SD) | oral | Rat | ToxValDB PPRTV (CPHEA) |
| 1281 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 26.89 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 1243 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 2277 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| LCcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| =0.5 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| =0.75 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| >2000 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| AZE05TDV2V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP ICE cancer |
| 1 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| =210 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =710 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =8 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB ToxRefDB |
| =8 | mg/kg bw/day | LEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =14 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =14 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =16 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB ToxRefDB |
| =16 | mg/kg bw/day | LEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =25 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =25 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =32 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB EPA TSCA 8e |
| =32 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB ToxRefDB |
| =32 | mg/kg bw/day | LEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =40 | mg/kg bw/day | LEL | dermal | Mouse | ToxValDB EPA TSCA 8e |
| =40 | mg/kg bw/day | LEL | dermal | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =77 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =77 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =79 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =79 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =80 | mg/kg bw/day | LEL | dermal | Mouse | ToxValDB EPA TSCA 8e |
| =80 | mg/kg bw/day | LEL | dermal | Mouse | ToxValDB ToxRefDB |
| =80 | mg/kg bw/day | LEL | dermal | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =100 | ppm | LEL | oral | Rat | ToxValDB EPA TSCA 8e |
| =104 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =104 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =125 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB ToxRefDB |
| =125 | mg/kg bw/day | LEL | dermal | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =142 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =142 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =160 | mg/kg bw/day | LEL | dermal | Mouse | ToxValDB ToxRefDB |
| =160 | mg/kg bw/day | LEL | dermal | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =205 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
Showing 50 of 80 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2'-iminodiethanol | 203-868-0 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Diethanolamine | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Diethanolamine (CAS 111-42-2) is classified under EU CLP Annex VI as Acute Tox. 4 *; STOT RE 2 *; Skin Irrit. 2; Eye Dam. 1 with signal word Danger. Hazard statements: H302; H373 **; H315; H318. Source: EU CLP Annex VI (ECHA).
Diethanolamine has 80 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
Diethanolamine appears on 11 regulatory/inventory lists including pharmaceutical, banned; Europe; Personal care, agricultural; detected; Pesticides; surface_water, and 8 more. Source: EPA CPDat.
Diethanolamine is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2011). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Diethanolamine is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Occupational exposure limits for Diethanolamine are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Diethanolamine is also indexed as a cosmetic ingredient under the name Diethanolamine (restrictions). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Diethanolamine is classified GHS Danger (H302, H373, H315, H318) in the chemicals database but is allowed in EU cosmetics at max 10%.
Diethanolamine also appears in cosmetics, pharmaceutical databases.