NOAEL Data REACH Registered Cosmetic Ingredient

Octane

Also known as: EINECS 203-892-1, Oktanen, UNII-X1RV0B2FJV, CH3-[CH2]6-CH3, Oktan (+1 more)

CAS 111-65-9

Octane (CAS 111-65-9) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for OCTANE →

Cross-Vertical Regulatory Divergence

Octane is classified GHS Danger (H225, H302, H304, H312, H315, H319, H336, H400) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields

Name

Octane

CAS Number

111-65-9

DTXSID

DTXSID0026882

Molecular Formula

C8H18

InChI Key

TVMXDCGIABBOFY-UHFFFAOYSA-N

Monoisotopic Mass

114.140851

Synonyms

EINECS 203-892-1OktanenUNII-X1RV0B2FJVCH3-[CH2]6-CH3Oktann-Oktan

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure to high concentrations of vapour could cause lowering of consciousness.
Long-term Effects	Repeated or prolonged contact with skin may cause dermatitis. The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 7 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	500 ppm (2350 mg/m³)	500	2350	N
NIOSH	TWA	75 ppm (350 mg/m³)	75	350	N
NIOSH	CEILING	385 ppm (1800 mg/m³) [15 minutes]	385	1800	N
ACGIH	TWA	300 ppm [1979]	300	-	N
CAL/OSHA	TWA	300 ppm (1450 mg/m³)	300	1450	N
CAL/OSHA	STEL	375 ppm (1800 mg/m³)	375	1800	N
NIOSH	IDLH	1000 ppm	1000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

SolventDegradant/impurity

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 8 records

List	Keyword	Source
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Personal care	Elsevier	CPCat
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 15 of 15 studies

Value	Unit	Endpoint	Route	Species	Source
3.5	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
3.5	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
=2035	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
X1RV0B2FJV	UNII	FDA UNII substance identifier	-	-	openFDA substances
X1RV0B2FJV	UNII	FDA UNII substance identifier	-	-	openFDA substances
X1RV0B2FJV	UNII	FDA UNII substance identifier	-	-	openFDA substances
X1RV0B2FJV	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.1031	fraction	Fu	-	Human	NTP_ICE_adme_parameters
0.1897	fraction	Fu	-	Rat	NTP_ICE_adme_parameters
117.943	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
118	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=46720.9	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
>14000	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=4672.09	mg/m3	NOAEL	inhalation	Mouse	ToxValDB_TX_TCEQ
=7475.34	mg/m3	NOAEL	inhalation	Rat	ToxValDB_TX_TCEQ

Showing 15 of 15 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Octane	203-892-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL OCTANE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Octane?

Octane has 15 NOAEL studies in the database. The lowest reported value is 3.5 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Octane?

Octane appears on 6 regulatory/inventory lists including air; detected; emissions; Europe; Toys and children's products, consumer_product; detected; Europe, air; detected; emissions; Personal care, and 3 more. Source: EPA CPDat.

What are the occupational exposure limits for Octane?

Occupational exposure limits for Octane are set by OSHA, NIOSH, ACGIH. 7 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Octane used in cosmetics?

Yes, Octane is also indexed as a cosmetic ingredient under the name OCTANE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Octane come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Octane have different safety status in cosmetics vs industrial chemicals?

Octane is classified GHS Danger (H225, H302, H304, H312, H315, H319, H336, H400) in the chemicals database but is allowed in EU cosmetics.

Is Octane used outside industrial chemicals?

Octane also appears in cosmetics, pharmaceutical, cannabis databases.