NOAEL Data REACH Registered Cosmetic Ingredient

1-Octene

Also known as: Caprylene, alpha-Octylene, 1-n-Octene, Dialen 8, Gulftene 8 (+10 more)

CAS 111-66-0

1-Octene (CAS 111-66-0) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for OCTENE →

Cross-Vertical Regulatory Divergence

1-Octene is classified GHS Danger (H225, H304, H315, H411, H332, H336, H400, H410) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields

Name

1-Octene

CAS Number

111-66-0

DTXSID

DTXSID6025804

Molecular Formula

C8H16

InChI Key

KWKAKUADMBZCLK-UHFFFAOYSA-N

Monoisotopic Mass

112.125201

Synonyms

Caprylenealpha-Octylene1-n-OcteneDialen 8Gulftene 8Linealene 8Octa-1,8-dienen-1-Octenen-octene-1Oct-1-eneUN 1993EINECS 203-893-7

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure at high levels could cause lowering of consciousness.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

Flavouring and nutrientFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 14 of 14 studies

Value	Unit	Endpoint	Route	Species	Source
E5VK21B9RC	UNII	FDA UNII substance identifier	-	-	openFDA substances
E5VK21B9RC	UNII	FDA UNII substance identifier	-	-	openFDA substances
E5VK21B9RC	UNII	FDA UNII substance identifier	-	-	openFDA substances
E5VK21B9RC	UNII	FDA UNII substance identifier	-	-	openFDA substances
=32127.4	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=13768.9	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=44	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=44	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=44	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=50	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_HESS
=100	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=300	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1000	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 14 of 14 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Oct-1-ene	203-893-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1376677

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 1-Octene?

1-Octene has 14 NOAEL studies in the database. The lowest reported value is E5VK21B9RC UNII. Source: openFDA substances.

What regulatory lists include 1-Octene?

1-Octene appears on 5 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, CEDI, IFRA Transparency, and 2 more. Source: EPA CPDat.

Is 1-Octene used in cosmetics?

Yes, 1-Octene is also indexed as a cosmetic ingredient under the name OCTENE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Octene come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 1-Octene have different safety status in cosmetics vs industrial chemicals?

1-Octene is classified GHS Danger (H225, H304, H315, H411, H332, H336, H400, H410) in the chemicals database but is allowed in EU cosmetics.

Is 1-Octene used outside industrial chemicals?

1-Octene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.