NOAEL Data REACH Registered Cosmetic Ingredient

Hexadecyl trimethyl ammonium chloride

Also known as: Cetyl trimethyl ammonium chloride, 1-Hexadecanaminium, N,N,N-trimethyl-, chloride, Arquad 16/28, Caswell No. 167A, EINECS 203-928-6 (+6 more)

CAS 112-02-7

Hexadecyl trimethyl ammonium chloride (CAS 112-02-7) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Cetrimonium Chloride →

SOURCE NOAEL studies
NOAEL studies
100
SOURCE Chemical inventory jurisdictions
Regulatory lists
10
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields
Name
Hexadecyl trimethyl ammonium chloride
CAS Number
112-02-7
DTXSID
DTXSID6026901
Molecular Formula
C19H42N.ClH
InChI Key
WOWHHFRSBJGXCM-UHFFFAOYSA-M
Monoisotopic Mass
320.308403
Synonyms
Cetyl trimethyl ammonium chloride1-Hexadecanaminium, N,N,N-trimethyl-, chlorideArquad 16/28Caswell No. 167AEINECS 203-928-6EPA Pesticide Chemical Code 069133UNII-UC9PE95IBPCTACTrimethylhexadecylammonium chloridecetyl(trimethyl)ammonium chloridehexadecyl(trimethyl)ammonium chloride

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
Surfactant (surface active agent)Softener and conditionerAnti-caking agentBiocidePreservativeAnti-static agentEmulsifier

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 10 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
inert_ingredient; non_food_use; PesticidesEPACPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
=0.052mg/kg bw/day-oralratRegulatory source
3.3----Regulatory source
=10mg/kg bw/day-oralratRegulatory source
54----Regulatory source
UC9PE95IBPUNIIFDA UNII substance identifier--openFDA substances
UC9PE95IBPUNIIFDA UNII substance identifier--openFDA substances
UC9PE95IBPUNIIFDA UNII substance identifier--openFDA substances
UC9PE95IBPUNIIFDA UNII substance identifier--openFDA substances
=450mg/kg bwLD50oralRatNTP ICE acute oral
=699mg/kg bwLD50oralRatNTP ICE acute oral
=861mg/kg bwLD50oralRatNTP ICE acute oral
=10mg/kg bw/dayLOAELdermalRabbitECHA
=400mg/kg bw/dayLOELoralMouseToxValDB ECOTOX
=600mg/kg bw/dayLOELoralMouseToxValDB ECOTOX
=0.052mg/kg bw/dayNOAELoralratSCCS Opinion
=0.052mg/kg bw/dayNOAELoralratSCCS Opinion
=0.052mg/kg bw/dayNOAELoralratSCCS Opinion
=0.052mg/kg bw/dayNOAELoralratSCCS Opinion
=0.8mg/kgNOAELoralratSCCS Opinion
=0.8mg/kgNOAELoralratSCCS Opinion
=0.8mg/kgNOAELoralratSCCS Opinion
=0.8mg/kgNOAELoralratSCCS Opinion
=2.5%NOAELdermalratSCCS Opinion
=2.5%NOAELdermalratSCCS Opinion
=2.5%NOAELdermalratSCCS Opinion
=2.5%NOAELdermalratSCCS Opinion
=3.3-NOAEL--SCCS Opinion
=3.3-NOAEL--SCCS Opinion
=3.3-NOAEL--SCCS Opinion
=3.3-NOAEL--SCCS Opinion
=9.9%NOAELdermal-SCCS Opinion
=9.9%NOAELdermal-SCCS Opinion
=9.9%NOAELdermal-SCCS Opinion
=9.9%NOAELdermal-SCCS Opinion
=10mg/kgNOAELoralratSCCS Opinion
=10mg/kg bw/dayNOAELoral-SCCS Opinion
=10mg/kgNOAELoralratSCCS Opinion
=10mg/kgNOAELoralratSCCS Opinion
=10mg/kg bw/dayNOAELoral-SCCS Opinion
=10mg/kg bw/dayNOAELoral-SCCS Opinion
=10mg/kgNOAELoralratSCCS Opinion
=10mg/kg bw/dayNOAELoral-SCCS Opinion
=12.5mg/kg bw/dayNOAELdermalratSCCS Opinion
=12.5mg/kg bw/dayNOAELdermalratSCCS Opinion
=12.5mg/kg bw/dayNOAELdermalratSCCS Opinion
=12.5mg/kg bw/dayNOAELdermalratSCCS Opinion
=24%NOAELdermalrabbitSCCS Opinion
=24%NOAELdermalrabbitSCCS Opinion
=24%NOAELdermalrabbitSCCS Opinion
=24%NOAELdermalrabbitSCCS Opinion

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredCetrimonium chloride203-928-6ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
0.5–3%
Category
surfactant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed HEXADECYLTRIMETHYLAMMONIUM CHLORIDE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Hexadecyl trimethyl ammonium chloride?

Hexadecyl trimethyl ammonium chloride has 100 NOAEL studies in the database. The lowest reported value is 0.052 mg/kg bw/day via oral in rat. Source: Regulatory source.

What regulatory lists include Hexadecyl trimethyl ammonium chloride?

Hexadecyl trimethyl ammonium chloride appears on 5 regulatory/inventory lists including Europe; Personal care; restricted, children; Europe; Personal care, Europe; Personal care, and 2 more. Source: EPA CPDat.

Is Hexadecyl trimethyl ammonium chloride used in cosmetics?

Yes, Hexadecyl trimethyl ammonium chloride is also indexed as a cosmetic ingredient under the name Cetrimonium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Hexadecyl trimethyl ammonium chloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Hexadecyl trimethyl ammonium chloride have different safety status in cosmetics vs industrial chemicals?

Hexadecyl trimethyl ammonium chloride is classified GHS Danger (H302, H311, H314, H315, H318, H335, H400, H410) in the chemicals database but is allowed in EU cosmetics at max 0.5–3%.

Is Hexadecyl trimethyl ammonium chloride used outside industrial chemicals?

Hexadecyl trimethyl ammonium chloride also appears in cosmetics, pharmaceutical databases.