NOAEL Data IARC Group 3 Cosmetic Ingredient

Quercetin

Also known as: 5-18-05-00494, BRN 0317313, CI Natural Yellow 10, EINECS 204-187-1, T-Gelb bzw. grun 1 (+14 more)

CAS 117-39-5

Quercetin (CAS 117-39-5) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC.

View cosmetic safety profile for Quercetin →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

Quercetin

CAS Number

117-39-5

DTXSID

DTXSID4021218

Molecular Formula

C15H10O7

InChI Key

REFJWTPEDVJJIY-UHFFFAOYSA-N

Monoisotopic Mass

302.042653

Synonyms

5-18-05-00494BRN 0317313CI Natural Yellow 10EINECS 204-187-1T-Gelb bzw. grun 1Quercetin contentQuercitinKvercetinUNII-9IKM0I5T1E2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chromen-4-one2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one3',4',5,7-Tetrahydroxyflavan-3-ol

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	1998	Sup 7, 73

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records

AntioxidantSoftener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
Canada; pharmaceutical	DrugBank	DrugBank
Canada; pharmaceutical	DrugBank	DrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies

Value	Unit	Endpoint	Route	Species	Source
18.0041706558517	uM	AC50	-	-	NTP_ICE_endocrine
14.525819346872	uM	ACC	-	-	NTP_ICE_endocrine
75.2	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
9IKM0I5T1E	UNII	FDA UNII substance identifier	-	-	openFDA substances
9IKM0I5T1E	UNII	FDA UNII substance identifier	-	-	openFDA substances
9IKM0I5T1E	UNII	FDA UNII substance identifier	-	-	openFDA substances
9IKM0I5T1E	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.0176	fraction	Fu	-	Human	NTP_ICE_adme_parameters
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP_ICE_cancer
=400	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=400	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=1600	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ToxRefDB
=1600	mg/kg bw/day	LOAEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=20	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECOTOX
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.101	unitless	Model Score	-	-	NTP_ICE_endocrine
>-	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=40	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=40	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=780	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=3120	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
40000	ppm	POLY-3 lowest dose	Dosed feed	Rat	NTP_ICE_cancer
4	%	Top dose	Dosed feed	Rat	NTP_ICE_cancer

Showing 26 of 26 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

0.1–0.5%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL QUERCETIN

ChEMBL Phase

Adverse Events

316

Bioactivity

167

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 2 records

FDA GRAS: FDA has no questions; some uses may require a color additive listing

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Quercetin?

Quercetin has 26 NOAEL studies in the database. The lowest reported value is 14.525819346872 uM. Source: NTP_ICE_endocrine.

What regulatory lists include Quercetin?

Quercetin appears on 2 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Canada; pharmaceutical. Source: EPA CPDat.

Is Quercetin a carcinogen according to IARC?

Quercetin is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Quercetin used in cosmetics?

Yes, Quercetin is also indexed as a cosmetic ingredient under the name Quercetin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Quercetin come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Quercetin used outside industrial chemicals?

Quercetin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.