What is the NOAEL for Quercetin?
Quercetin has 21 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
NOAEL Data
IARC Group 3
Cosmetic Ingredient
Quercetin
Also known as: 5-18-05-00494, BRN 0317313, CI Natural Yellow 10, EINECS 204-187-1, T-Gelb bzw. grun 1 (+14 more)
CAS 117-39-5
Quercetin (CAS 117-39-5) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC.
SOURCE
NOAEL studies
NOAEL studies
21
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
24 fields
Name
Quercetin
CAS Number
117-39-5
Molecular Formula
C15H10O7
InChI Key
REFJWTPEDVJJIY-UHFFFAOYSA-N
Monoisotopic Mass
302.042653
Synonyms
5-18-05-00494BRN 0317313CI Natural Yellow 10EINECS 204-187-1T-Gelb bzw. grun 1Quercetin contentQuercitinKvercetinUNII-9IKM0I5T1E2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chromen-4-one2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one3',4',5,7-Tetrahydroxyflavan-3-ol
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | Sup 7, 73 |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
5 records
AntioxidantSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 18 | uM | AC50 | - | - | NTP ICE endocrine |
| 14.53 | uM | ACC | - | - | NTP ICE endocrine |
| 75.2 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 9IKM0I5T1E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0176 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP ICE cancer |
| =400 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =400 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =1600 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB ToxRefDB |
| =1600 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =20 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB ECOTOX |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.101 | unitless | Model Score | - | - | NTP ICE endocrine |
| >0 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =40 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =40 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =780 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =3120 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 4.000e+4 | ppm | POLY-3 lowest dose | Dosed feed | Rat | NTP ICE cancer |
| 4 | % | Top dose | Dosed feed | Rat | NTP ICE cancer |
Showing 21 of 21 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
0.1–0.5%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
QUERCETIN
ChEMBL Phase
3
Adverse Events
316
Bioactivity
167
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
2 records
FDA GRAS: FDA has no questions; some uses may require a color additive listing
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Quercetin?
Quercetin appears on 2 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Canada; pharmaceutical. Source: EPA CPDat.
Is Quercetin a carcinogen according to IARC?
Quercetin is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Quercetin used in cosmetics?
Yes, Quercetin is also indexed as a cosmetic ingredient under the name Quercetin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Quercetin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Quercetin used outside industrial chemicals?
Quercetin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.