What is the NOAEL for Phenyl salicylate?
Phenyl salicylate has 13 NOAEL studies in the database. The lowest reported value is 28A37T47QO UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Phenyl salicylate
Also known as: BRN 0393969, EINECS 204-259-2, Fenylester kyseliny salicylove, UNII-28A37T47QO, 2-Hydroxy-benzoic acid phenyl ester (+2 more)
CAS 118-55-8
Phenyl salicylate (CAS 118-55-8) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Phenyl salicylate
CAS Number
118-55-8
DTXSID
DTXSID6021957
Molecular Formula
C13H10O3
InChI Key
ZQBAKBUEJOMQEX-UHFFFAOYSA-N
Monoisotopic Mass
214.062994
Synonyms
BRN 0393969EINECS 204-259-2Fenylester kyseliny salicyloveUNII-28A37T47QO2-Hydroxy-benzoic acid phenyl esterPhenyl-2-hydroxybenzoatesalol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
BiocideFragranceFlavouring and nutrientUV stabilizerAntioxidantThickening agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 28A37T47QO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 28A37T47QO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 28A37T47QO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 28A37T47QO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 4050 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =33.3 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| =1.8 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_EFSA |
| =1.8 | mg/kg bw/day | LOAEL | oral: drinking water | Mouse | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1.8 | mg/kg bw/day | LOAEL | oral: drinking water | Mouse | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Phenyl salicylate | 204-259-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
≤2% rinse-off / ≤0.5% leave-on
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PHENYL SALICYLATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Phenyl salicylate?
Phenyl salicylate appears on 5 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.
Is Phenyl salicylate used in cosmetics?
Yes, Phenyl salicylate is also indexed as a cosmetic ingredient under the name Phenyl Salicylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phenyl salicylate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Phenyl salicylate used outside industrial chemicals?
Phenyl salicylate also appears in cosmetics, pharmaceutical, cannabis databases.