What is the NOAEL for 2-Ethylhexyl salicylate?
2-Ethylhexyl salicylate has 12 NOAEL studies in the database. The lowest reported value is 4 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Ethylhexyl salicylate
Also known as: BRN 2730664, EINECS 204-263-4, Ethyl hexyl salicylate, UNII-4X49Y0596W
CAS 118-60-5
2-Ethylhexyl salicylate (CAS 118-60-5) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
2-Ethylhexyl salicylate
CAS Number
118-60-5
DTXSID
DTXSID7040734
Molecular Formula
C15H22O3
InChI Key
FMRHJJZUHUTGKE-UHFFFAOYSA-N
Monoisotopic Mass
250.156895
Synonyms
BRN 2730664EINECS 204-263-4Ethyl hexyl salicylateUNII-4X49Y0596W
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
21 records
UV stabilizerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =9.03 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4X49Y0596W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4X49Y0596W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4X49Y0596W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4X49Y0596W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.02 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| >180 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-ethylhexyl salicylate | 204-263-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
5%
Category
sunscreen
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
OCTISALATE
ChEMBL Phase
2
Adverse Events
100
Bioactivity
2
Frequently Asked Questions
What regulatory lists include 2-Ethylhexyl salicylate?
2-Ethylhexyl salicylate appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Canada; consumer_product; Substances in Products - Canada (4/2014), IFRA Transparency, and 3 more. Source: EPA CPDat.
Is 2-Ethylhexyl salicylate used in cosmetics?
Yes, 2-Ethylhexyl salicylate is also indexed as a cosmetic ingredient under the name Ethylhexyl Salicylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Ethylhexyl salicylate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Ethylhexyl salicylate used outside industrial chemicals?
2-Ethylhexyl salicylate also appears in cosmetics, pharmaceutical databases.