What is the NOAEL for Trimethoxymethylsilane?
Trimethoxymethylsilane has 13 NOAEL studies in the database. The lowest reported value is 25.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Trimethoxymethylsilane
Also known as: Silane, trimethoxymethyl-, EINECS 214-685-0, Silane A-163, Union carbide a-163, UNII-0HI0D71MCI
CAS 1185-55-3
Trimethoxymethylsilane (CAS 1185-55-3) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Trimethoxymethylsilane is classified GHS Danger (H225, H315, H317, H319, H335, H320, H332, H336) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Trimethoxymethylsilane
CAS Number
1185-55-3
DTXSID
DTXSID3027370
Molecular Formula
C4H12O3Si
InChI Key
BFXIKLCIZHOAAZ-UHFFFAOYSA-N
Monoisotopic Mass
136.055571
Synonyms
Silane, trimethoxymethyl-EINECS 214-685-0Silane A-163Union carbide a-163UNII-0HI0D71MCI
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
29 records
Film formerBinderDehydrating agent (desiccant)Chemical reaction regulatorProcessing aids not otherwise specifiedAdhesion/cohesion promoterHardenerDispersing agent
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =25.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =130 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0HI0D71MCI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0HI0D71MCI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0HI0D71MCI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0HI0D71MCI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >42.3445 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >144.7676 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >9500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| =557.148 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_TX_TCEQ |
| =2228.59 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_TX_TCEQ |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Trimethoxy(methyl)silane | 214-685-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3182654
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is Trimethoxymethylsilane used in cosmetics?
Yes, Trimethoxymethylsilane is also indexed as a cosmetic ingredient under the name METHYLTRIMETHOXYSILANE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Trimethoxymethylsilane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Trimethoxymethylsilane have different safety status in cosmetics vs industrial chemicals?
Trimethoxymethylsilane is classified GHS Danger (H225, H315, H317, H319, H335, H320, H332, H336) in the chemicals database but is allowed in EU cosmetics.
Is Trimethoxymethylsilane used outside industrial chemicals?
Trimethoxymethylsilane also appears in cosmetics, pharmaceutical databases.