What is the NOAEL for Ferric ammonium citrate?
Ferric ammonium citrate has 6 NOAEL studies in the database. The lowest reported value is 9.8 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ferric ammonium citrate
Also known as: FAC, 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, ammonium iron(3+) salt, Ammonium iron(III) citrate, Ammonium ferric citrate, Ammonium iron(3+) citrate (+11 more)
CAS 1185-57-5
Ferric ammonium citrate (CAS 1185-57-5) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
22 fields
Name
Ferric ammonium citrate
CAS Number
1185-57-5
DTXSID
DTXSID9040477
Molecular Formula
C6H8O7.Fe.H3N
InChI Key
FRHBOQMZUOWXQL-UHFFFAOYSA-K
Monoisotopic Mass
264.988488
Synonyms
FAC1,2,3-Propanetricarboxylic acid, 2-hydroxy-, ammonium iron(3+) saltAmmonium iron(III) citrateAmmonium ferric citrateAmmonium iron(3+) citrateAmmonium iron(3+) 2-hydroxy-1,2,3-propanetricarboxylateEINECS 214-686-6Ferric ammonium citrate, greenIron ammonium citrateIron ammonium citrate, greenIron(III) ammonium citrateFerri Seltz
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
5 records
DyeFlavouring and nutrientAnti-caking agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Medical/dental | FDA | United States Food and Drug Administration (FDA) |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Europe | European Commission | Fl@vis |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =9.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| UVP74NG1C5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UVP74NG1C5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UVP74NG1C5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UVP74NG1C5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =425 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ammonium iron(III) citrate | 214-686-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
11
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E381 — 1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ferric ammonium citrate?
Ferric ammonium citrate appears on 6 regulatory/inventory lists including Medical/dental, Europe; supplements, Europe; food_additive; supplements, and 3 more. Source: EPA CPDat.
Is Ferric ammonium citrate used in cosmetics?
Yes, Ferric ammonium citrate is also indexed as a cosmetic ingredient under the name Ferric Ammonium Citrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ferric ammonium citrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ferric ammonium citrate used outside industrial chemicals?
Ferric ammonium citrate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.