Also known as: Benzoic acid, 2-hydroxy-, methyl ester, Methyl 2-hydroxybenzoate, 2-Carbomethoxyphenol, PredaLure, 4-10-00-00143 (+15 more)
CAS 119-36-8
Methyl salicylate (CAS 119-36-8) is a chemical substance with GHS signal word Warning; key hazard signal: H361d; H302; H317; H412. Key regulatory status: REACH registered, 42 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC.
Methyl salicylate is classified GHS CMR hazard (H361d, H302, H317, H412) in the chemicals database but is restricted in EU cosmetics at max 0.001% (leave-on); 0.01% (rinse-off).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 2; Acute Tox. 4; Skin Sens. 1B; Aquatic Chronic 3 | H361d; H302; H317; H412 | GHS08; GHS07 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Harmful if swallowed May cause an allergic skin reaction Suspected of damaging fertility or the unborn child Harmful to aquatic life |
| Short-term Effects | The substance is irritating to the eyes. The substance may cause effects on the central nervous system and acid-base balance in the body when ingested in large amounts. This may result in delirium, tremors and coma. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. Animal tests show that this substance possibly causes toxicity to human reproduction or development. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| detected; MN Chemical Screening; surface_water | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| IFRA Transparency | IFRA | IFRA |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| Europe | European Commission | Fl@vis |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.9 | % | - | oral | rat | Regulatory source |
| 2.52 | % | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 31 | - | - | inhalation | - | Regulatory source |
| 50 | mg/kg bw/day | - | - | rat | Regulatory source |
| 75 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 75 | mg/kg | - | - | - | Regulatory source |
| 75 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 75 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 120 | ppm | - | - | - | Regulatory source |
| 120 | ppm | - | oral | - | Regulatory source |
| 1633 | - | - | oral | - | Regulatory source |
| 75000 | - | - | oral | - | Regulatory source |
| 75000 | - | - | oral | - | Regulatory source |
| 75000 | - | - | oral | - | Regulatory source |
| <=0.5 | mg/kg | ADI | oral | Human | WHO/JECFA |
| >200 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| >1065.043 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 95 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 542.4 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 817 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| =7.05 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| =9.87 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| =17.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| -2.4 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| - | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 0.2 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 0.3 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 0.4 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 3.4 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 9.1 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 11.3 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| -0.2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 1 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 1.3 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 1.6 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 2.9 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 3 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 22.9 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 24.4 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 24.6 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 0.7 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 0.8 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 0.9 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 0.95 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 3.15 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 5.05 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 7.15 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 11.65 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
Showing 50 of 100 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methyl salicylate | 204-317-7 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1676/25 | 30 April 2025 | Safe with restrictions for children 0-3 years | ≤0.4% toothpaste; ≤0.02% all other leave-on and rinse-off products (0-3 year olds) | CMR Cat.2 (reproductive toxicity); aggregate systemic salicylate exposure; revision of SCCS/1654/23 |
| SCCS/1654/23 | 14 September 2023 | Safe with restrictions for children 0.5-3 years and 3-6 years | 0.02% most products (0.5-3 yr); 2.52% toothpaste (0.5-3 yr); see Table 1 for 3-6 yr age group limits | CMR Cat.2 (reproductive toxicity); systemic salicylate exposure; aggregate salicylate exposure from multiple products |
| SCCS/1633/21 | 26-27 October 2021 | Safe with restrictions per Table 1 | Per Table 1 by product type; 2.52% toothpaste; ≤0.1% mouthwash (children ≤10 yr) | CMR Cat.2 (reproductive toxicity); skin sensitiser Cat.1B; systemic salicylate exposure; aggregate exposure with other salicylates |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Methyl salicylate (CAS 119-36-8) is classified under EU CLP Annex VI as Repr. 2; Acute Tox. 4; Skin Sens. 1B; Aquatic Chronic 3 with signal word Warning. Hazard statements: H361d; H302; H317; H412. Source: EU CLP Annex VI (ECHA).
Methyl salicylate has 100 NOAEL studies in the database. The lowest reported value is -2.4 % via Dermal. Source: NTP ICE skin sensitization.
Methyl salicylate appears on 16 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Australia, inert_ingredient; non_food_use; Pesticides, and 13 more. Source: EPA CPDat.
Yes, Methyl salicylate is also indexed as a cosmetic ingredient under the name Methyl Salicylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Methyl salicylate is classified GHS CMR hazard (H361d, H302, H317, H412) in the chemicals database but is restricted in EU cosmetics at max 0.001% (leave-on); 0.01% (rinse-off).
Methyl salicylate also appears in cosmetics, pharmaceutical, cannabis databases.