What is the NOAEL for Icaridin?
Icaridin has 27 NOAEL studies in the database. The lowest reported value is 12.56 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Icaridin
Also known as: 1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1-methylpropyl ester, Picaridin, Butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate, Autan, Autan Repel (+14 more)
CAS 119515-38-7
Icaridin (CAS 119515-38-7) is a chemical substance. Key regulatory status: REACH registered, 43 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
View cosmetic safety profile for Hydroxyethyl Isobutyl Piperidine Carboxylate (Icaridin/Picaridin) →
SOURCE
NOAEL studies
NOAEL studies
27
SOURCE
Chemical inventory jurisdictions
Regulatory lists
43
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Icaridin
CAS Number
119515-38-7
Molecular Formula
C12H23NO3
InChI Key
QLHULAHOXSSASE-UHFFFAOYSA-N
Monoisotopic Mass
229.167794
Synonyms
1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1-methylpropyl esterPicaridinButan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylateAutanAutan RepelIsobutyl 2-(2-hydroxyethyl)-1-piperidinecarboxylateNatrapelKBR 3023sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate\Icaridine1-methylpropyl 2-(2-hydroxyethyl)piperidine-1-carboxylateAcido 1-Piperidinecarboxilic, 2 - (2-hidroxietil) -, 1-metilpropil ester1-(1-Methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Biocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
43 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 27 of 27 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 12.56 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| N51GQX0837 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.2842 | fraction | Fu | - | Human | NTP ICE adme parameters |
| =50 | mg/kg bw/day | LEL | dermal | Rabbit | ToxValDB ToxRefDB |
| =50 | mg/kg bw/day | LEL | dermal | rabbit | EPA ToxRefDB v3 |
| =149 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =149 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| >200 | mg/kg bw/day | LEL | dermal | Rabbit | ToxValDB ToxRefDB |
| >200 | mg/kg bw/day | LEL | dermal | rabbit | EPA ToxRefDB v3 |
| =382 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =382 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| >400 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB ToxRefDB |
| >400 | mg/kg bw/day | LEL | dermal | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| >200 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB ToxRefDB |
| >200 | mg/kg bw/day | LOAEL | dermal | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| =1033 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB ToxRefDB |
| =1033 | mg/kg bw/day | LOAEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| =1192 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB ToxRefDB |
| =1192 | mg/kg bw/day | LOAEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| >0 | mg/kg bw/day | NEL | dermal | rabbit | EPA ToxRefDB v3 |
| =100 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =100 | mg/kg bw/day | NEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| =194 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =194 | mg/kg bw/day | NEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| =301 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB ToxRefDB |
| =301 | mg/kg bw/day | NOAEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
Showing 27 of 27 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (RS)-sec-butyl (RS)-2-(2-hydroxyethyl)piperidine-1-carboxylate | 423-210-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ICARIDIN
ChEMBL Phase
2
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Icaridin?
Icaridin appears on 5 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical, active_ingredient; Pesticides, and 2 more. Source: EPA CPDat.
Is Icaridin used in cosmetics?
Yes, Icaridin is also indexed as a cosmetic ingredient under the name Hydroxyethyl Isobutyl Piperidine Carboxylate (Icaridin/Picaridin). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Icaridin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Icaridin used outside industrial chemicals?
Icaridin also appears in cosmetics, pharmaceutical databases.