NOAEL Data REACH Registered Cosmetic Ingredient

Piperonal

Also known as: Benzaldehyde, 3,4-(methylenedioxy)-, 3,4-Bis(methylenedioxy)benzaldehyde, Dioxymethylene protocatechuic aldehyde, Dioxymethylene-protocatechuic aldehyde, EINECS 204-409-7 (+6 more)

CAS 120-57-0

Piperonal (CAS 120-57-0) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Heliotropine →

Cross-Vertical Regulatory Divergence

Piperonal is classified GHS Danger (H317, H301, H312, H330, H336, H351, H360, H370) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

Piperonal

CAS Number

120-57-0

Molecular Formula

C8H6O3

InChI Key

SATCULPHIDQDRE-UHFFFAOYSA-N

Monoisotopic Mass

150.031694

Synonyms

Benzaldehyde, 3,4-(methylenedioxy)-3,4-Bis(methylenedioxy)benzaldehydeDioxymethylene protocatechuic aldehydeDioxymethylene-protocatechuic aldehydeEINECS 204-409-7FEMA No. 29113,4-Methylene-dihydroxybenzaldehydeUNII-KE109YAK003,4-methylenedioxybenzaldehydeheliotropinepiperonyl aldehyde

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

FragranceDeodorizerSoftener and conditionerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 14 of 14 studies

Value	Unit	Endpoint	Route	Species	Source
<=2.5	mg/kg	ADI	oral	Human	WHO/JECFA
=5.29	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
KE109YAK00	UNII	FDA UNII substance identifier	-	-	openFDA substances
0	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
3724	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
100	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
250	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=250	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=250	mg/kg bw/day	NOAEL	oral	Rat	EFSA
=250	mg/kg bw/day	NOAEL	-	Rat	EFSA
=300	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=390	mg/kg bw/day	NOAEL	oral	Rat	ECHA
1000	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
2	unitless	Relative reliability score	Dermal	Human	NTP ICE skin sensitization

Showing 14 of 14 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Piperonal	204-409-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed PIPERONAL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

ADI: 0-2.5 mg/kg bw (1967) mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Piperonal?

Piperonal has 14 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include Piperonal?

Piperonal appears on 7 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe, IFRA Transparency, and 4 more. Source: EPA CPDat.

Is Piperonal used in cosmetics?

Yes, Piperonal is also indexed as a cosmetic ingredient under the name Heliotropine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Piperonal come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Piperonal have different safety status in cosmetics vs industrial chemicals?

Piperonal is classified GHS Danger (H317, H301, H312, H330, H336, H351, H360, H370) in the chemicals database but is restricted in EU cosmetics.

Is Piperonal used outside industrial chemicals?

Piperonal also appears in cosmetics, pharmaceutical, food safety, cannabis databases.