What is the NOAEL for Indole?
Indole has 11 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Indole
Also known as: 2,3-Benzopyrole, Benzopyrrole, 1-Benzo(b)pyrrole, Caswell No. 498B, EINECS 204-420-7 (+5 more)
CAS 120-72-9
Indole (CAS 120-72-9) is a chemical substance. Key regulatory status: REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Indole is classified GHS Danger (H302, H311, H318, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
11
SOURCE
Chemical inventory jurisdictions
Regulatory lists
23
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Indole
CAS Number
120-72-9
Molecular Formula
C8H7N
InChI Key
SIKJAQJRHWYJAI-UHFFFAOYSA-N
Monoisotopic Mass
117.057849
Synonyms
2,3-BenzopyroleBenzopyrrole1-Benzo(b)pyrroleCaswell No. 498BEINECS 204-420-7EPA Pesticide Chemical Code 025000FEMA No. 2593UNII-8724FJW4M5Indol1H-indole
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
21 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
23 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| detected; wastewater | USGS | United States Geological Survey (USGS) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Raw materials | Air Water INC | Air Water INC |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.64 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| =9.87 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 8724FJW4M5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 648 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =1000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 112 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =117 | mg/kg bw/day | NOEL | injection | Rat | ToxValDB ECOTOX |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Indole | 204-420-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
aroma_chemical
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
INDOLE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
5
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Indole?
Indole appears on 13 regulatory/inventory lists including active_ingredient; Pesticides, detected; wastewater, active_ingredient; Europe; Pesticides, and 10 more. Source: EPA CPDat.
Is Indole used in cosmetics?
Yes, Indole is also indexed as a cosmetic ingredient under the name Indole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Indole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Indole have different safety status in cosmetics vs industrial chemicals?
Indole is classified GHS Danger (H302, H311, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Is Indole used outside industrial chemicals?
Indole also appears in cosmetics, pharmaceutical, food safety, cannabis databases.