What is the NOAEL for 3-Ethoxy-4-hydroxybenzaldehyde?
3-Ethoxy-4-hydroxybenzaldehyde has 27 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3-Ethoxy-4-hydroxybenzaldehyde
Also known as: Ethyl vanillin, BRN 1073761, EINECS 204-464-7, 3-Ethoxyprotocatechualdehyde, Ethyl protal (+7 more)
CAS 121-32-4
3-Ethoxy-4-hydroxybenzaldehyde (CAS 121-32-4) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
27
SOURCE
Chemical inventory jurisdictions
Regulatory lists
7
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
3-Ethoxy-4-hydroxybenzaldehyde
CAS Number
121-32-4
Molecular Formula
C9H10O3
InChI Key
CBOQJANXLMLOSS-UHFFFAOYSA-N
Monoisotopic Mass
166.062994
Synonyms
Ethyl vanillinBRN 1073761EINECS 204-464-73-EthoxyprotocatechualdehydeEthyl protalEthylprotocatechualdehyde-3-ethyl etherEthylprotocatechuic aldehydeFEMA No. 2464VanilalVanillin, ethyl-VaniromeUNII-YC9ST449YJ
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerHumectantFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 27 of 27 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=3 | mg/kg | ADI | oral | Human | WHO/JECFA |
| >1163 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 569.5 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| =49 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 1.1 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 9.7 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 45.1 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 5.4 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 23 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 161.7 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| YC9ST449YJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 5.4 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 500 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =500 | mg/kg bw/day | NOAEL | - | Rat | EFSA |
| 505 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 545 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =1000 | ppm | NOAEL | oral | Rat | ECHA |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 27 of 27 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-ethoxy-4-hydroxybenzaldehyde | 204-464-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
aroma_chemical
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ETHYL VANILLIN
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: 0-3 mg/kg bw (1995) mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 3-Ethoxy-4-hydroxybenzaldehyde?
3-Ethoxy-4-hydroxybenzaldehyde appears on 7 regulatory/inventory lists including Australia; Food and drug - smoking-related products, IFRA Transparency, Europe, and 4 more. Source: EPA CPDat.
Is 3-Ethoxy-4-hydroxybenzaldehyde used in cosmetics?
Yes, 3-Ethoxy-4-hydroxybenzaldehyde is also indexed as a cosmetic ingredient under the name Ethyl Vanillin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-Ethoxy-4-hydroxybenzaldehyde come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 3-Ethoxy-4-hydroxybenzaldehyde used outside industrial chemicals?
3-Ethoxy-4-hydroxybenzaldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.