Danger GHS07GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

2-Phenoxyethanol

Also known as: Ethylene glycol monophenyl ether, Phenoxetol, Phenyl cellosolve, 4-06-00-00571, AI3-00752()C (+14 more)

CAS 122-99-6

2-Phenoxyethanol (CAS 122-99-6) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H335; H318. Key regulatory status: REACH registered, 56 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Phenoxyethanol →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
56
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
2-Phenoxyethanol
CAS Number
122-99-6
DTXSID
DTXSID9021976
Molecular Formula
C8H10O2
InChI Key
QCDWFXQBSFUVSP-UHFFFAOYSA-N
Monoisotopic Mass
138.06808
Synonyms
Ethylene glycol monophenyl etherPhenoxetolPhenyl cellosolve4-06-00-00571AI3-00752()CBRN 1364011EINECS 204-589-7Glycol monophenyl etherbeta-Hydroxyethyl phenyl etherPhenylmonoglycol etherRose ether2-Fenoxyethanol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4; STOT SE 3; Eye Dam. 1H302; H335; H318GHS07; GHS05Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system and peripheral nervous system. This may result in impaired functions.
Long-term EffectsThe substance defats the skin, which may cause dryness or cracking. The substance may have effects on the central nervous system. This may result in impaired functions.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
PreservativeAntioxidantFragranceBiocideStabilizing agentProcessing aids not otherwise specifiedPlasticizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 56 records
ListKeywordSource
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; EuropeDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
artificial_sweat; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
artificial_saliva; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Personal care - linimentDanish Environmental Protection AgencyDanish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
artificial_saliva; detected; emissions; Europe; Other indirect contact consumer goodsDanish Environmental Protection AgencyDanish EPA
artificial_saliva; detected; emissions; Europe; Other indirect contact consumer goodsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - linimentDanish Environmental Protection AgencyDanish EPA
detected; Personal care; Southeast AsiaAseanASEAN Cosmetics
Arts and crafts/Office supplies - fabric treatment and dye; detectedDanish Environmental Protection AgencyDanish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
detected; Europe; Personal care - nails - nail polishDanish Environmental Protection AgencyDanish EPA
Europe; Specialty occupational productsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - sexual wellnessDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - linimentDanish Environmental Protection AgencyDanish EPA
Europe; pharmaceuticalDrinking Water InspectorateCPCat
IFRA TransparencyIFRAIFRA
Personal care; Southeast AsiaAseanASEAN Cosmetics
consumer_productP&GProctor & Gamble
Arts and crafts/Office supplies - fabric treatment and dye; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - linimentDanish Environmental Protection AgencyDanish EPA
CEDIFDAUnited States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; PesticidesEPACPCat
consumer_product; EuropeDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - body hygiene - body washDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bubble bathDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - hair styling and care - shampooDanish Environmental Protection AgencyDanish EPA
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
0.2%-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.5%-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.5%-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.5%---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1%-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1---humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1---humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2mg/kg-intravenous-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
2mg/kg---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2---humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
2---humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
2----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2.69mg/kg/d-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=2.69mg/kg bw/day-dermalrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
4.5----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
5----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
7%---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
9--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
10----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
13----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
13----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
13----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
13----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
13--dermalrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
61--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
75--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
75--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
75--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
75--oralmouseUnifiedCodex:SCCS_SHADOW:beta.noael_studies
75--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
75--oralmouseUnifiedCodex:SCCS_SHADOW:beta.noael_studies
79%-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
80mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
80--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
164mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
164mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
164mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
164mg/kg bw/day-dermalrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
164mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
249--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=357mg/kg bw/d-dermalrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=357mg/kg bw/d-dermalrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
357mg/kg bw/day-dermalrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
357mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
357mg/kg bw/day-dermalrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
357mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-phenoxyethanol204-589-7ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1575/166 October 2016Safe — safe at 1% in all cosmetic products for all age groups including infants1% in all cosmetic productsHaemotoxicity (critical endpoint for safety assessment); neurotoxicity concerns in young children evaluated; MoS acceptable at 1%

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
1.0%
Category
preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL PHENOXYETHANOL
ChEMBL Phase
-1
Adverse Events
384
Bioactivity
2
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Phenoxyethanol?

2-Phenoxyethanol (CAS 122-99-6) is classified under EU CLP Annex VI as Acute Tox. 4; STOT SE 3; Eye Dam. 1 with signal word Danger. Hazard statements: H302; H335; H318. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Phenoxyethanol?

2-Phenoxyethanol has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 2-Phenoxyethanol?

2-Phenoxyethanol appears on 41 regulatory/inventory lists including Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; detected; Europe, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe, air; detected; emissions; Europe; Toys and children's products, and 38 more. Source: EPA CPDat.

Is 2-Phenoxyethanol used in cosmetics?

Yes, 2-Phenoxyethanol is also indexed as a cosmetic ingredient under the name Phenoxyethanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Phenoxyethanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Phenoxyethanol have different safety status in cosmetics vs industrial chemicals?

2-Phenoxyethanol is classified GHS Danger (H302, H335, H318) in the chemicals database but is restricted in EU cosmetics at max 1.0%.

Is 2-Phenoxyethanol used outside industrial chemicals?

2-Phenoxyethanol also appears in cosmetics, pharmaceutical, food safety databases.