What is the NOAEL for Cetylpyridinium chloride?
Cetylpyridinium chloride has 45 NOAEL studies in the database. The lowest reported value is 2.5 mg/kg bw/day via oral. Source: Regulatory source.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Cetylpyridinium chloride
Also known as: Pyridinium, 1-hexadecyl-, chloride, Caswell No. 166A, Ceeprin chloride, Cetyl pyridinium chloride, Cetylpyridini chloridum (+8 more)
CAS 123-03-5
Cetylpyridinium chloride (CAS 123-03-5) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Cetylpyridinium chloride is classified GHS Danger (H301, H302, H315, H318, H330, H335, H400, H410) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
45
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Cetylpyridinium chloride
CAS Number
123-03-5
Molecular Formula
C21H38N.ClH
InChI Key
YMKDRGPMQRFJGP-UHFFFAOYSA-M
Monoisotopic Mass
340.277103
Synonyms
Pyridinium, 1-hexadecyl-, chlorideCaswell No. 166ACeeprin chlorideCetyl pyridinium chlorideCetylpyridini chloridumEINECS 204-593-9EPA Pesticide Chemical Code 069160NSC 14864Swabettes HoechstCetilpiridinio cloruroCetylpyridinii chloridumUNII-6BR7T22E2S
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
20 records
Surfactant (surface active agent)BiocideAnti-static agentDeodorizerEmulsifierSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 45 of 45 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2.5 | mg/kg bw/day | - | oral | - | Regulatory source |
| <5 | mg/kg bw/day | - | - | - | Regulatory source |
| 5 | mg/kg bw/day | - | oral | - | Regulatory source |
| <5 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 15 | mg/kg bw/day | - | - | - | Regulatory source |
| 18 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 25 | mg/kg bw/day | - | - | - | Regulatory source |
| 50 | % | - | oral | - | Regulatory source |
| 74 | - | - | - | - | Regulatory source |
| 90 | - | - | - | rat | Regulatory source |
| 113 | - | - | - | - | Regulatory source |
| 120 | - | - | - | - | Regulatory source |
| 156 | - | - | - | - | Regulatory source |
| 192 | - | - | - | - | Regulatory source |
| 205 | - | - | - | - | Regulatory source |
| 250 | mg/kg bw/day | - | - | - | Regulatory source |
| 250 | ppm | - | oral | rat | Regulatory source |
| 360 | - | - | - | - | Regulatory source |
| 500 | - | - | - | - | Regulatory source |
| 1000 | ppm | - | oral | rat | Regulatory source |
| 1385 | - | - | - | - | Regulatory source |
| 1875 | - | - | - | - | Regulatory source |
| 4.170e+4 | - | - | - | - | Regulatory source |
| 6BR7T22E2S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.09 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =200 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2.5 | mg/kg bw/day | NOAEL | oral | - | SCCS Opinion |
| =5 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| <5 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =10 | % | NOAEL | oral | - | SCCS Opinion |
| =12 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
| =15 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =15 | mg/kg/day | NOAEL | oral | rat | SCCS Opinion |
| =18 | mg/kg bw/day | NOAEL | oral | rat | SCCS Opinion |
| >25 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
| =25 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =50 | % | NOAEL | oral | - | SCCS Opinion |
| =60 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =60 | mg/kg/day | NOAEL | oral | rat | SCCS Opinion |
| =74 | - | NOAEL | - | - | SCCS Opinion |
| =90 | - | NOAEL | - | rat | SCCS Opinion |
| =100 | mg/kg bw/day | NOAEL | - | rat | SCCS Opinion |
| =113 | - | NOAEL | - | - | SCCS Opinion |
| =120 | - | NOAEL | - | - | SCCS Opinion |
| =156 | - | NOAEL | - | - | SCCS Opinion |
Showing 45 of 45 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cetylpyridinium chloride | 204-593-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1548/15 | 15 December 2015 | safe with restrictions | 0.1% in mouthwash and other oral hygiene products | Antimicrobial preservative; low systemic exposure from oral products |
| SCCP/0920/05 | 28 March 2006 | Insufficient data — dossier inadequate and non-compliant with standards; new dossier required | N/A (assessment not possible) | Poor quality and non-standard dossier; studies conducted on formulations not pure substance; inadequate data on genotoxicity, sensitization, and systemic toxicity |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL34833
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
7
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
FDA GRAS: At the notifier's request, FDA ceased to evaluate this notice
View full food safety profile →Frequently Asked Questions
What regulatory lists include Cetylpyridinium chloride?
Cetylpyridinium chloride appears on 4 regulatory/inventory lists including pharmaceutical, CEDI, Indirect additives food contact (10/2018), and 1 more. Source: EPA CPDat.
Is Cetylpyridinium chloride used in cosmetics?
Yes, Cetylpyridinium chloride is also indexed as a cosmetic ingredient under the name Cetylpyridinium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Cetylpyridinium chloride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Cetylpyridinium chloride have different safety status in cosmetics vs industrial chemicals?
Cetylpyridinium chloride is classified GHS Danger (H301, H302, H315, H318, H330, H335, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Is Cetylpyridinium chloride used outside industrial chemicals?
Cetylpyridinium chloride also appears in cosmetics, pharmaceutical, food safety databases.