NOAEL Data REACH Registered Cosmetic Ingredient

3-Methylbutyl acetate

Also known as: Isoamyl acetate, 4-02-00-00157, Amyl acetate, common, BRN 1744750, EINECS 204-662-3 (+15 more)

CAS 123-92-2

3-Methylbutyl acetate (CAS 123-92-2) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Isoamyl Acetate →

Cross-Vertical Regulatory Divergence

3-Methylbutyl acetate is classified GHS Danger (H226, H316, H320, H335, H336, H372) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

3-Methylbutyl acetate

CAS Number

123-92-2

DTXSID

DTXSID9025453

Molecular Formula

C7H14O2

InChI Key

MLFHJEHSLIIPHL-UHFFFAOYSA-N

Monoisotopic Mass

130.09938

Synonyms

Isoamyl acetate4-02-00-00157Amyl acetate, commonBRN 1744750EINECS 204-662-3FEMA No. 2055FEMA Number 2055In Commercial practice amyl invariably means isoamyl, unless it is prefaced by the n- for normalbeta-Methylbutyl acetate2-Methylbutyl ethanoateIsoamylester kyseliny octoveUNII-Z135787824

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The vapour is irritating to the eyes and respiratory tract. Exposure to high concentrations of vapour could cause unconsciousness.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 7 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	100 ppm (525 mg/m³)	100	525	N
NIOSH	TWA	100 ppm (525 mg/m³)	100	525	N
ACGIH	TWA	50 ppm [1997]	50	-	N
ACGIH	STEL	100 ppm [1997]	100	-	N
CAL/OSHA	TWA	50 ppm (266 mg/m³)	50	266	N
CAL/OSHA	STEL	100 ppm (532 mg/m³)	100	532	N
NIOSH	IDLH	1000 ppm	1000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

SolventNo specific technical functionFlavouring and nutrientFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 10 records

List	Keyword	Source
air; detected; emissions; Personal care	Elsevier	CPCat
air; Cleaning products and household care - air freshener; detected; emissions	Elsevier	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
consumer_product; detected	Elsevier	CPCat
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
consumer_product	P&G	Proctor & Gamble
Europe	European Commission	Fl@vis

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 41 of 41 studies

Value	Unit	Endpoint	Route	Species	Source
<=3	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
=3	mg/kg bw/day	ADI (group)	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=3	mg/kg bw/day	ADI (group)	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=20.8	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
Z135787824	UNII	FDA UNII substance identifier	-	-	openFDA substances
Z135787824	UNII	FDA UNII substance identifier	-	-	openFDA substances
Z135787824	UNII	FDA UNII substance identifier	-	-	openFDA substances
Z135787824	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
5184	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
21260	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
=16600	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1250	mg/kg bw/day	LEL	oral	Chicken	ToxValDB_EFSA
=53246.5	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=50	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=50	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=125	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=125	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=125	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>219	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>219	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>219	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>300	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>300	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>300	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=340	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=340	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=340	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>1000	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>1000	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>1450	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>1450	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>1450	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>2500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>2500	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>2500	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 41 of 41 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Isopentyl acetate	204-662-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL42013

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0-3 mg/kg bw (1979) mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 3-Methylbutyl acetate?

3-Methylbutyl acetate has 41 NOAEL studies in the database. The lowest reported value is 3 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.

What regulatory lists include 3-Methylbutyl acetate?

3-Methylbutyl acetate appears on 10 regulatory/inventory lists including air; detected; emissions; Personal care, air; Cleaning products and household care - air freshener; detected; emissions, inert_ingredient; non_food_use; Pesticides, and 7 more. Source: EPA CPDat.

What are the occupational exposure limits for 3-Methylbutyl acetate?

Occupational exposure limits for 3-Methylbutyl acetate are set by OSHA, NIOSH, ACGIH. 7 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 3-Methylbutyl acetate used in cosmetics?

Yes, 3-Methylbutyl acetate is also indexed as a cosmetic ingredient under the name Isoamyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3-Methylbutyl acetate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 3-Methylbutyl acetate have different safety status in cosmetics vs industrial chemicals?

3-Methylbutyl acetate is classified GHS Danger (H226, H316, H320, H335, H336, H372) in the chemicals database but is allowed in EU cosmetics.

Is 3-Methylbutyl acetate used outside industrial chemicals?

3-Methylbutyl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.