What is the GHS hazard classification for Octanoic acid?
Octanoic acid (CAS 124-07-2) is classified under EU CLP Annex VI as Skin Corr. 1C; Aquatic Chronic 3 with signal word Danger. Hazard statements: H314; H412. Source: EU CLP Annex VI (ECHA).
Danger
GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
Octanoic acid
Also known as: Caprylic acid, 4-02-00-00982, BRN 1747180, EINECS 204-677-5, Enantic acid (+15 more)
CAS 124-07-2
Octanoic acid (CAS 124-07-2) is a chemical substance with GHS signal word Danger; key hazard signal: H314; H412. Key regulatory status: REACH registered, 41 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Octanoic acid is classified GHS Danger (H314, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
41
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Octanoic acid
CAS Number
124-07-2
DTXSID
DTXSID3021645
Molecular Formula
C8H16O2
InChI Key
WWZKQHOCKIZLMA-UHFFFAOYSA-N
Monoisotopic Mass
144.11503
Synonyms
Caprylic acid4-02-00-00982BRN 1747180EINECS 204-677-5Enantic acidFEMA No. 2799Hexacid 898Octic acidOctylic acidKyselina kaprylovaUNII-OBL58JN0251-Heptanecarboxylate
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Skin Corr. 1C; Aquatic Chronic 3 | H314; H412 | GHS05 | Danger |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
19 records
Surfactant (surface active agent)DeodorizerEmulsifierFragranceCleaning agentNo specific technical functionFlavouring and nutrientPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
41 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 22.1030149415202 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 27.5774384180333 | uM | ACC | - | - | NTP_ICE_endocrine |
| 240 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| 158.7 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 5.408 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 70.49 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 359 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 5.626 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| -1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.9 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.9 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.8 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.45 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| OBL58JN025 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OBL58JN025 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OBL58JN025 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OBL58JN025 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 1 | unitless | GHS classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| 1.1 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =0.5 | mmol | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =1 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =2 | mmol | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =2.3 | mg/mi | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =15 | mmol/kg | LOEL | injection | Mouse | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00457 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0142 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =2700 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <62.5 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| =350 | mM | NOEL | injection | Rat | ToxValDB_ECOTOX |
| =5000 | ppm | NOEL | oral | European Rabbit | ToxValDB_ECOTOX |
| 76.2 | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.6 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 3.8 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 10.4 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 10.6 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 13.4 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 18.5 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 2 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 2.7 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 3 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 3.4 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Octanoic acid | 204-677-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
OCTANOIC ACID
ChEMBL Phase
2
Adverse Events
664
Bioactivity
6
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: ACCEPTABLE mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Octanoic acid?
Octanoic acid has 100 NOAEL studies in the database. The lowest reported value is -1 % via Dermal. Source: NTP_ICE_skin_sensitization.
What regulatory lists include Octanoic acid?
Octanoic acid appears on 16 regulatory/inventory lists including Europe; Personal care, active_ingredient; Pesticides, Canada; pharmaceutical, and 13 more. Source: EPA CPDat.
Is Octanoic acid used in cosmetics?
Yes, Octanoic acid is also indexed as a cosmetic ingredient under the name Caprylic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Octanoic acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Octanoic acid have different safety status in cosmetics vs industrial chemicals?
Octanoic acid is classified GHS Danger (H314, H412) in the chemicals database but is allowed in EU cosmetics.
Is Octanoic acid used outside industrial chemicals?
Octanoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.