What is the NOAEL for Butylated hydroxytoluene?
Butylated hydroxytoluene has 100 NOAEL studies in the database. The lowest reported value is 0.25 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Butylated hydroxytoluene
Also known as: BHT, 2,6-bis(1,1-Dimethylethyl)-4-methyl-phenol, 2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, p-Cresol, 2,6-di-tert-butyl- (+14 more)
CAS 128-37-0
Butylated hydroxytoluene (CAS 128-37-0) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH, ILO ICSC, OSHA.
View cosmetic safety profile for BHT (Butylated Hydroxytoluene) →
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Butylated hydroxytoluene
CAS Number
128-37-0
DTXSID
DTXSID2020216
Molecular Formula
C15H24O
InChI Key
NLZUEZXRPGMBCV-UHFFFAOYSA-N
Monoisotopic Mass
220.182715
Synonyms
BHT2,6-bis(1,1-Dimethylethyl)-4-methyl-phenol2,6-Di-tert-butyl-4-methylphenol2,6-Di-tert-butyl-p-cresolp-Cresol, 2,6-di-tert-butyl-Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-Antrancine 8Butylated hydroxytoluolCaswell No. 291ACatalin antioxydant 1Catalin cao-3Di-tert-butyl-p-methylphenol
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 40, Sup 7 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and skin. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the liver. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 10 mg/m³ | - | 10 | N |
| ACGIH | TWA | 2 mg/m³ (inhalable fraction and vapor) [2001] | - | 2 | N |
| CAL/OSHA | TWA | 10 mg/m³ | - | 10 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Stabilizing agentFragrancePreservativeAntioxidantDeodorizerFlavouring and nutrientPharmaceuticalDegradant/impurityDefoamer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - children's art and toys - modeling clay; detected | Springer | Published Articles |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Europe | European Chemicals Agency | European Chemicals Agency (ECHA) |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Food contact items | Danish Environmental Protection Agency | Danish EPA |
| air; drinking_water; Europe; soil | Danish Environmental Protection Agency | Danish EPA |
| children; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods; Toys and children's products | Danish EPA | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Raw materials | Danish Environmental Protection Agency | Danish EPA |
| Europe; Other direct contact consumer goods; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.5 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 7 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 15 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 15 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 20 | mg/kg/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | mg/kg bw | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | mg/kg bw | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | mg/kg bw | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | dermal | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 28 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 30 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 32 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 33 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 34 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 35 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 67 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 75 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | - | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 125 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,6-di-tert-butyl-p-cresol | 204-881-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1636/21 | 27 September 2021 | safe with restrictions | 0.001% mouthwash; 0.1% toothpaste; 0.8% other leave-on and rinse-off products | Slight skin/eye irritation; endocrine disrupting properties evaluated; liver as main target via oral route; environmental aspects not covered |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.001% (mouthwash), 0.1% (toothpaste), 0.8% (other products)
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BUTYLATED HYDROXYTOLUENE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
8
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E321 — ADI: 0.25 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Butylated hydroxytoluene?
Butylated hydroxytoluene appears on 41 regulatory/inventory lists including Arts and crafts/Office supplies - children's art and toys - modeling clay; detected, detected; MN Chemical Screening; surface_water, air; detected; emissions; Europe; Toys and children's products, and 38 more. Source: EPA CPDat.
Is Butylated hydroxytoluene a carcinogen according to IARC?
Butylated hydroxytoluene is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for Butylated hydroxytoluene?
Occupational exposure limits for Butylated hydroxytoluene are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Butylated hydroxytoluene used in cosmetics?
Yes, Butylated hydroxytoluene is also indexed as a cosmetic ingredient under the name BHT (Butylated Hydroxytoluene). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butylated hydroxytoluene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Butylated hydroxytoluene used outside industrial chemicals?
Butylated hydroxytoluene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.