NOAEL Data REACH Registered Cosmetic Ingredient

2-Hydroxy-4-methoxybenzophenone

Also known as: BRN 1913145, EINECS 205-031-5, NCI-C60957, NSC-7778, Oxibenzonum (+4 more)

CAS 131-57-7

2-Hydroxy-4-methoxybenzophenone (CAS 131-57-7) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Benzophenone-3 (Oxybenzone) →

SOURCE NOAEL studies
NOAEL studies
66
SOURCE Chemical inventory jurisdictions
Regulatory lists
16
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 14 fields
Name
2-Hydroxy-4-methoxybenzophenone
CAS Number
131-57-7
Molecular Formula
C14H12O3
InChI Key
DXGLGDHPHMLXJC-UHFFFAOYSA-N
Monoisotopic Mass
228.078644
Synonyms
BRN 1913145EINECS 205-031-5NCI-C60957NSC-7778OxibenzonumSunscreen UV-15OxybenzonumUNII-95OOS7VE0YBenzophenone-3

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 53 records
UV stabilizerFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 16 records
ListKeywordSource
Cleaning products and household care - shoes; EuropeDanish Environmental Protection AgencyDanish EPA
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Food contact itemsDanish Environmental Protection AgencyDanish EPA
Europe; restrictedDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
Cleaning products and household care - shoes; EuropeDanish Environmental Protection AgencyDanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
pharmaceuticalUS International Trade CommissionCPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
detected; Europe; Personal care - nails - nail polishDanish Environmental Protection AgencyDanish EPA
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
Europe; Personal careEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 66 studies
ValueUnitEndpointRouteSpeciesSource
-3----Regulatory source
0.5%---Regulatory source
1----Regulatory source
2----Regulatory source
3----Regulatory source
3.2----Regulatory source
5----Regulatory source
6--oral-Regulatory source
6%---Regulatory source
8----Regulatory source
9----Regulatory source
10%---Regulatory source
10%--ratRegulatory source
13---ratRegulatory source
25----Regulatory source
30%---Regulatory source
35--oral-Regulatory source
36----Regulatory source
56----Regulatory source
62----Regulatory source
67----Regulatory source
67.9mg/kg bw/d-oral-Regulatory source
73----Regulatory source
97----Regulatory source
>99%--mouseRegulatory source
99.8%---Regulatory source
=100mg/kg bw/day-oralratRegulatory source
140mg/kg bw/day-oralratRegulatory source
140mg/kg bw/day-dermal-Regulatory source
=200mg/kg bw/day-dermalratRegulatory source
=200mg/kg bw/day-dermal-Regulatory source
200mg/kg bw/day--ratRegulatory source
311mg/kg bw/day-oralratRegulatory source
311mg/kg bw/day-oral-Regulatory source
=364mg/kg bw/day-dermal-Regulatory source
=364mg/kg bw/day-dermalmouseRegulatory source
393mg/kg bw/day-oralratRegulatory source
393mg/kg bw/day-oral-Regulatory source
=400mg/kg bw/day---Regulatory source
=411mg/kg/ day-oralratRegulatory source
432mg/kg bw/day-dermal-Regulatory source
=828mg/kg bw/day---Regulatory source
1000----Regulatory source
1000mg/kg bw/day---Regulatory source
1000ppm---Regulatory source
1050mg/kg bw/day-oral-Regulatory source
1254---ratRegulatory source
1425mg/kg bw/day-oral-Regulatory source
1538----Regulatory source
1625---ratRegulatory source

Showing 50 of 66 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredOxybenzone205-031-5ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 4 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1625/2030-31 March 2021safe with restrictions6% in face cream, hand cream, lipstick; 2.2% in body cream and spray products; 0.5% as product formulation protectantPotential endocrine disrupting properties; systemic absorption concerns at full-body application; photostability concerns; restricted due to insufficient MoS for body application
SCCP/1201/0816 December 2008safe with restrictionsup to 6% as UV filter; up to 0.5% as product protectantData insufficient to calculate MoS in 2006 opinion (SCCP/0998/06); revised opinion with new absorption data confirmed safe at 6% with specific product restrictions; estrogenic activity concerns
SCCP/0998/0619 December 2006No safe concentration established in this opinion; 6% was queriedDermal absorption data insufficient; MoS could not be calculated; estrogenic activity concerns noted
SCCP/1069/0619 December 2006It is the opinion of the SCCP that insufficient data are presented to calculate the Margin of Safety of Benzophenone-3 under the proposed conditions of use. The following additional information is required: - A dermal absorption study with Benzophenone-3 under its in-use concentrations (up to 10%) according to OECD Guideline 428 combined with SCCP/0970/06.10%Insufficient data to calculate the Margin of Safety under the proposed conditions of use; a dermal absorption study at in-use concentrations (up to 10%) per OECD Guideline 428 is required (requested before end of March 2007); no concern found for photo-induced toxicity or (photo)genotoxicity.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
6% (sunscreen); 0.5% (non-UV-filter use)
Category
UV Filter / Benzophenone
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed OXYBENZONE
ChEMBL Phase
4
Adverse Events
51
Bioactivity
5
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-Hydroxy-4-methoxybenzophenone?

2-Hydroxy-4-methoxybenzophenone has 66 NOAEL studies in the database. The lowest reported value is -3 mg/kg bw/day. Source: Regulatory source.

What regulatory lists include 2-Hydroxy-4-methoxybenzophenone?

2-Hydroxy-4-methoxybenzophenone appears on 12 regulatory/inventory lists including Cleaning products and household care - shoes; Europe, drinking_water; Europe; manufacturing; plastic_additive, Europe; Personal care, and 9 more. Source: EPA CPDat.

Is 2-Hydroxy-4-methoxybenzophenone used in cosmetics?

Yes, 2-Hydroxy-4-methoxybenzophenone is also indexed as a cosmetic ingredient under the name Benzophenone-3 (Oxybenzone). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Hydroxy-4-methoxybenzophenone come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Hydroxy-4-methoxybenzophenone used outside industrial chemicals?

2-Hydroxy-4-methoxybenzophenone also appears in cosmetics, pharmaceutical databases.