What is the NOAEL for 2-Hydroxy-4-methoxybenzophenone?
2-Hydroxy-4-methoxybenzophenone has 100 NOAEL studies in the database. The lowest reported value is -3 mg/kg bw/day. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Hydroxy-4-methoxybenzophenone
Also known as: BRN 1913145, EINECS 205-031-5, NCI-C60957, NSC-7778, Oxibenzonum (+4 more)
CAS 131-57-7
2-Hydroxy-4-methoxybenzophenone (CAS 131-57-7) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for Benzophenone-3 (Oxybenzone) →
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
16
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
2-Hydroxy-4-methoxybenzophenone
CAS Number
131-57-7
DTXSID
DTXSID3022405
Molecular Formula
C14H12O3
InChI Key
DXGLGDHPHMLXJC-UHFFFAOYSA-N
Monoisotopic Mass
228.078644
Synonyms
BRN 1913145EINECS 205-031-5NCI-C60957NSC-7778OxibenzonumSunscreen UV-15OxybenzonumUNII-95OOS7VE0YBenzophenone-3
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
53 records
UV stabilizerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
16 records
| List | Keyword | Source |
|---|---|---|
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Food contact items | Danish Environmental Protection Agency | Danish EPA |
| Europe; restricted | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| detected; Europe; Personal care - nails - nail polish | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| -3 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| -3 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| -3 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| -3 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| -3 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| -3 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 0.5 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 0.5 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3.2 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3.2 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3.2 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 5 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6 | - | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 8 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 9 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 9 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 9 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | % | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 13 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 30 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 35 | - | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 36 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 36 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 56 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 56 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 62 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 67 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 67.9 | mg/kg bw/d | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 67.9 | mg/kg bw/d | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 67.9 | mg/kg bw/d | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 73 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 97 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 97 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 97 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Oxybenzone | 205-031-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1625/20 | 30-31 March 2021 | safe with restrictions | 6% in face cream, hand cream, lipstick; 2.2% in body cream and spray products; 0.5% as product formulation protectant | Potential endocrine disrupting properties; systemic absorption concerns at full-body application; photostability concerns; restricted due to insufficient MoS for body application |
| SCCP/1201/08 | 16 December 2008 | safe with restrictions | up to 6% as UV filter; up to 0.5% as product protectant | Data insufficient to calculate MoS in 2006 opinion (SCCP/0998/06); revised opinion with new absorption data confirmed safe at 6% with specific product restrictions; estrogenic activity concerns |
| SCCP/0998/06 | 19 December 2006 | insufficient data (first submission; data gap) | No safe concentration established in this opinion; 6% was queried | Dermal absorption data insufficient; MoS could not be calculated; estrogenic activity concerns noted |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
6% (sunscreen); 0.5% (non-UV-filter use)
Category
UV Filter / Benzophenone
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
OXYBENZONE
ChEMBL Phase
4
Adverse Events
51
Bioactivity
5
Frequently Asked Questions
What regulatory lists include 2-Hydroxy-4-methoxybenzophenone?
2-Hydroxy-4-methoxybenzophenone appears on 12 regulatory/inventory lists including Cleaning products and household care - shoes; Europe, drinking_water; Europe; manufacturing; plastic_additive, Europe; Personal care, and 9 more. Source: EPA CPDat.
Is 2-Hydroxy-4-methoxybenzophenone used in cosmetics?
Yes, 2-Hydroxy-4-methoxybenzophenone is also indexed as a cosmetic ingredient under the name Benzophenone-3 (Oxybenzone). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Hydroxy-4-methoxybenzophenone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Hydroxy-4-methoxybenzophenone used outside industrial chemicals?
2-Hydroxy-4-methoxybenzophenone also appears in cosmetics, pharmaceutical databases.