What is the NOAEL for Iron oxide (Fe3O4)?
Iron oxide (Fe3O4) has 8 NOAEL studies in the database. The lowest reported value is 0.5 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Iron oxide (Fe3O4)
Also known as: EINECS 215-277-5, UNII-XM0M87F357, ferric ferrous oxide, ferro ferric oxide, iron(II,III) oxide
CAS 1317-61-9
Iron oxide (Fe3O4) (CAS 1317-61-9) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for CI 77499 (Black Iron Oxide) →
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
Iron oxide (Fe3O4)
CAS Number
1317-61-9
DTXSID
DTXSID5029639
Synonyms
EINECS 215-277-5UNII-XM0M87F357ferric ferrous oxideferro ferric oxideiron(II,III) oxide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
11 records
PigmentDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| general_foods | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=0.5 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| XM0M87F357 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XM0M87F357 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XM0M87F357 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XM0M87F357 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =5 | mg/kg bw/day | LEL | injection | Mouse | ToxValDB_ECHA_IUCLID |
| >50 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =4.7 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Triiron tetraoxide | 215-277-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
colorant
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E172 (Black) — ADI: 0.5 mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Iron oxide (Fe3O4)?
Iron oxide (Fe3O4) appears on 7 regulatory/inventory lists including Europe; Personal care, Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; Pesticides, and 4 more. Source: EPA CPDat.
Is Iron oxide (Fe3O4) used in cosmetics?
Yes, Iron oxide (Fe3O4) is also indexed as a cosmetic ingredient under the name CI 77499 (Black Iron Oxide). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Iron oxide (Fe3O4) come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Iron oxide (Fe3O4) used outside industrial chemicals?
Iron oxide (Fe3O4) also appears in cosmetics, food safety databases.