What is the NOAEL for Polyquaternium-28?
Polyquaternium-28 has 4 NOAEL studies in the database. The lowest reported value is 6M8B654MEQ UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Polyquaternium-28
Also known as: 2-Methyl-N-[3-(trimethylazaniumyl)propyl]prop-2-enimidate--1-ethenylpyrrolidin-2-one--hydrogen chloride (1/1/1), Gafquat HS-100, N,N,N-Trimethyl-3-((2-methyl-1-oxo-2-propenyl)amino)-1-propanaminium chloride, Copolymer of vinylpyrrolidone and methacrylamidopropyl trimethylammonium, 2-Pyrrolidinone, 1-ethenyl-, polymer with N,N,N-trimethyl- (+3 more)
CAS 131954-48-8
Polyquaternium-28 (CAS 131954-48-8) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Polyquaternium-28
CAS Number
131954-48-8
DTXSID
DTXSID40927424
Synonyms
2-Methyl-N-[3-(trimethylazaniumyl)propyl]prop-2-enimidate--1-ethenylpyrrolidin-2-one--hydrogen chloride (1/1/1)Gafquat HS-100N,N,N-Trimethyl-3-((2-methyl-1-oxo-2-propenyl)amino)-1-propanaminium chlorideCopolymer of vinylpyrrolidone and methacrylamidopropyl trimethylammonium2-Pyrrolidinone, 1-ethenyl-, polymer with N,N,N-trimethyl-1-Propanaminium, N,N,N-trimethyl-3-[(2-methyl-1-oxo-2-propen-1-yl)amino]-, chloride (1:1), polymer with 1-ethenyl-2-pyrrolidinone2-Pyrrolidinone, 1-ethenyl-, polymer with N,N,N-trimethyl-3-[(2-methyl-1-oxo-2-propenyl)amino]-1-propanaminium chlorideUNII-6M8B654MEQ
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
Film formerAnti-static agentHair fixativeFixing agent (mordant)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6M8B654MEQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6M8B654MEQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6M8B654MEQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6M8B654MEQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
conditioning agent
Frequently Asked Questions
What regulatory lists include Polyquaternium-28?
Polyquaternium-28 appears on 1 regulatory/inventory list including Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.
Is Polyquaternium-28 used in cosmetics?
Yes, Polyquaternium-28 is also indexed as a cosmetic ingredient under the name Polyquaternium-28. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Polyquaternium-28 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Polyquaternium-28 used outside industrial chemicals?
Polyquaternium-28 also appears in cosmetics databases.