What is the NOAEL for Sorbitan monododecanoate?
Sorbitan monododecanoate has 16 NOAEL studies in the database. The lowest reported value is 10 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sorbitan monododecanoate
Also known as: Sorbitan monolaurate, Span(R) 20, Sorbitan, monododecanoate, Sorbitan, monolaurate, EINECS 215-663-3 (+4 more)
CAS 1338-39-2
Sorbitan monododecanoate (CAS 1338-39-2) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Sorbitan monododecanoate
CAS Number
1338-39-2
DTXSID
DTXSID6027395
Synonyms
Sorbitan monolaurateSpan(R) 20Sorbitan, monododecanoateSorbitan, monolaurateEINECS 215-663-3Radiasurf 7125Emasol Super L 10(F)Sorbitani laurasUNII-6W9PS8B71J
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
22 records
EmulsifierSurfactant (surface active agent)Anti-static agentDispersing agentWetting agent (non-aqueous)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =21 | mg/kg bw | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =21 | mg/kg bw | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| <=25 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =10 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =10 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 6W9PS8B71J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6W9PS8B71J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6W9PS8B71J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6W9PS8B71J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =850 | mg/kg bw/day | LEL | oral | Cow Family | ToxValDB_EFSA |
| =8500 | mg/kg bw/day | LEL | oral | Chicken | ToxValDB_EFSA |
| =5 | % diet | NOAEL | oral | Hamster | ToxValDB_HPVIS |
| =580 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =2100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =2600 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_EFSA |
| =2600 | mg/kg bw/day | NOAEL | oral: feed | Mouse | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sorbitan laurate | 215-663-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SORBITAN MONOLAURATE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E493 — ADI: 25 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Sorbitan monododecanoate?
Sorbitan monododecanoate appears on 6 regulatory/inventory lists including pharmaceutical, Europe; plastic_additive, drinking_water; Europe; manufacturing; plastic_additive, and 3 more. Source: EPA CPDat.
Is Sorbitan monododecanoate used in cosmetics?
Yes, Sorbitan monododecanoate is also indexed as a cosmetic ingredient under the name SORBITAN LAURATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sorbitan monododecanoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Sorbitan monododecanoate used outside industrial chemicals?
Sorbitan monododecanoate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.