What is the GHS hazard classification for DEET?
DEET (CAS 134-62-3) is classified under EU CLP Annex VI as Acute Tox. 4; Skin Irrit. 2; Eye Irrit. 2 with signal word Warning. Hazard statements: H302; H315; H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
Cosmetic Ingredient
DEET
Also known as: N,N-Diethyl-m-toluamide, N,N-Diethyl-3-methylbenzamide, N,N-Diethyl-meta-toluamide, DEET (N,N-diethyl-meta-toluamide), BRN 2046711 (+9 more)
CAS 134-62-3
DEET (CAS 134-62-3) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H315; H319. Key regulatory status: 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
DEET is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
65
SOURCE
Chemical inventory jurisdictions
Regulatory lists
60
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
DEET
CAS Number
134-62-3
Molecular Formula
C12H17NO
InChI Key
MMOXZBCLCQITDF-UHFFFAOYSA-N
Monoisotopic Mass
191.131014
Synonyms
N,N-Diethyl-m-toluamideN,N-Diethyl-3-methylbenzamideN,N-Diethyl-meta-toluamideDEET (N,N-diethyl-meta-toluamide)BRN 2046711Caswell No. 346EINECS 205-149-7EPA Pesticide Chemical Code 080301MGK diethyltoluamideRepper-DETDiethyltoluamidumDietiltoluamida
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4; Skin Irrit. 2; Eye Irrit. 2 | H302; H315; H319 | GHS07 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
HumectantNo specific technical functionBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; MN Chemical Screening; wastewater | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; ground_water; MN Chemical Screening | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 65 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 52.94 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 492.3 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 504.2 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 3.797 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 6.7 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 6.1 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 4000 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 2 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 3 | unitless | EPA classification | Dermal | Rat | NTP ICE acute dermal |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP ICE acute oral |
| 4 | unitless | EPA classification | Dermal | Rabbit | NTP ICE skin irritation |
| FB0C1XZV4Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.3559 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 4 | unitless | GHS Classification | Inhalation | - | NTP ICE acute inhalation |
| =4 | Unitless | GHS classification | oral | Rat (Female) | NTP ICE acute oral |
| 5 | unitless | GHS classification | Dermal | Rat | NTP ICE acute dermal |
| 1914 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 1.07 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 1.076 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| >2.3 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 5.862 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 5.95 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 6.047 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =1950 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >2000 | mg/kg | LD50 | Dermal | Rat | NTP ICE acute dermal |
| =2000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =3000 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| =90 | mg/kg bw/day | LEL | oral | rat | EPA ToxRefDB v3 |
| =250 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Crl:COBS CD) | EPA ToxRefDB v3 |
| =304 | mg/kg bw/day | LEL | oral | Hamster | ToxValDB ToxRefDB |
| =304 | mg/kg bw/day | LEL | oral | hamster (golden syrian; golden syrian) | EPA ToxRefDB v3 |
| >325 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB ToxRefDB |
| >325 | mg/kg bw/day | LEL | oral | rabbit (new zealand white; New Zealand White) | EPA ToxRefDB v3 |
| =400 | mg/kg bw/day | LEL | oral | Dog | ToxValDB ToxRefDB |
| =400 | mg/kg bw/day | LEL | oral | dog (beagle; beagle) | EPA ToxRefDB v3 |
| =500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =500 | mg/kg bw/day | LEL | oral | rat (sprague-dawley; sprague-dawley) | EPA ToxRefDB v3 |
| =636 | mg/kg bw/day | LEL | oral | Hamster | ToxValDB ToxRefDB |
| =636 | mg/kg bw/day | LEL | oral | hamster (golden syrian; golden syrian) | EPA ToxRefDB v3 |
| =750 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =750 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague-Dawley COBS CD (SD) BR) | EPA ToxRefDB v3 |
| =1000 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =1000 | mg/kg bw/day | LEL | oral | mouse (cd1; Crl: CD-1) | EPA ToxRefDB v3 |
| 750 | mg/kg bw/day | LOEL | Oral | Rat | NTP ICE dart |
| =1 | mg/kg bw/day | MRL | oral | Human | ToxValDB ATSDR MRLs |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| >0 | mg/kg bw/day | NEL | oral | rat (sprague-dawley; sprague-dawley) | EPA ToxRefDB v3 |
Showing 50 of 65 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
DIETHYLTOLUAMIDE
ChEMBL Phase
3
Adverse Events
72
Bioactivity
3
Frequently Asked Questions
What is the NOAEL for DEET?
DEET has 65 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
What regulatory lists include DEET?
DEET appears on 8 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), detected; MN Chemical Screening; surface_water, detected; drinking_water; MN Chemical Screening, and 5 more. Source: EPA CPDat.
Is DEET used in cosmetics?
Yes, DEET is also indexed as a cosmetic ingredient under the name Diethyl Toluamide (DEET). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for DEET come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does DEET have different safety status in cosmetics vs industrial chemicals?
DEET is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319).
Is DEET used outside industrial chemicals?
DEET also appears in cosmetics, pharmaceutical databases.