Danger GHS08GHS06GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Zinc pyrithione

Also known as: Zinc, bis[1-(hydroxy-kappaO)-2(1H)-pyridinethionato-.kappa.S2]-, (T-4)-, Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-, Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-, (T-4)-, Zinc, bis(1-(hydroxy-kappaO)-2(1H)-pyridinethionato-kappaS2)-, (T-4)-, Zinc, bis[1-(hydroxy-.kappa.O)-2(1H)-pyridinethionato-.kappa.S2]-, (T-4)- (+14 more)

CAS 13463-41-7

Zinc pyrithione (CAS 13463-41-7) is a chemical substance with GHS signal word Danger; key hazard signal: H360D; H330; H301; H372; H318; H400; H410. Key regulatory status: REACH registered, 35 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Zinc Pyrithione →

Cross-Vertical Regulatory Divergence

Zinc pyrithione is prohibited in EU cosmetics at max 0% but has active industrial GHS classifications (H360D, H330, H301, H372, H318, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

100

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

Zinc pyrithione

CAS Number

13463-41-7

DTXSID

DTXSID7026314

Molecular Formula

2C5H4NOS.Zn

InChI Key

PICXIOQBANWBIZ-UHFFFAOYSA-N

Monoisotopic Mass

315.931862

Synonyms

Zinc, bis[1-(hydroxy-kappaO)-2(1H)-pyridinethionato-.kappa.S2]-, (T-4)-Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-, (T-4)-Zinc, bis(1-(hydroxy-kappaO)-2(1H)-pyridinethionato-kappaS2)-, (T-4)-Zinc, bis[1-(hydroxy-.kappa.O)-2(1H)-pyridinethionato-.kappa.S2]-, (T-4)-Bis(2-pyridinethiol-1-oxide)zincBis(2-pyridylthio)zinc 1,1'-dioxideBreck One Dandruff ShampooCaswell No. 923EINECS 236-671-3EPA Pesticide Chemical Code 088002Head and Shoulders

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1	H360D; H330; H301; H372; H318; H400; H410	GHS08; GHS06; GHS05; GHS09	Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

PreservativeSoftener and conditionerPharmaceuticalAnti-dandruffBiocideDegradant/impurity

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 35 records

List	Keyword	Source
pharmaceutical	US International Trade Commission	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
Europe; Personal care - hair styling and care - shampoo-dandruff	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
Europe; Personal care - hair styling and care - shampoo-dandruff	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
0.5	mg/kg/day	-	oral	rat	Regulatory source
0.5	mg/kg/day	-	oral	rat	Regulatory source
0.5	mg/kg/d	-	oral	rat	Regulatory source
0.5	mg/kg/d	-	oral	-	Regulatory source
0.6	mg/kg/d	-	oral	rat	Regulatory source
2	mg/kg/d	-	oral	-	Regulatory source
5	mg/kg bw/d	-	dermal	rat	Regulatory source
5	mg/kg bw/d	-	dermal	rat	Regulatory source
11	mg/kg bw/d	-	oral	rat	Regulatory source
14	-	-	oral	rat	Regulatory source
25	mg/kg bw/d	-	dermal	-	Regulatory source
50	ppm	-	-	rat	Regulatory source
100	mg/kg bw/d	-	oral	mouse	Regulatory source
500	-	-	-	rat	Regulatory source
500	-	-	oral	rat	Regulatory source
1995	-	-	oral	rat	Regulatory source
0.246652718	uM	AC50	-	-	NTP ICE endocrine
2.04176096879569	uM	AC50	-	-	NTP ICE endocrine
0.190148851	uM	ACC	-	-	NTP ICE endocrine
1.85188882209664	uM	ACC	-	-	NTP ICE endocrine
1	unitless	EPA Classification	Ocular	Rabbit	NTP ICE eye irritation
4	unitless	EPA Classification	Inhalation	-	NTP ICE acute inhalation
3	unitless	EPA classification	Dermal	Rat	NTP ICE acute dermal
=3	Unitless	EPA classification	oral	Rat	NTP ICE acute oral
=3	Unitless	EPA classification	oral	Rat (Female)	NTP ICE acute oral
=3	Unitless	EPA classification	oral	Rat (Female)	NTP ICE acute oral
=3	Unitless	EPA classification	oral	Rat (Female)	NTP ICE acute oral
3	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
3	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
4	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
4	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
R953O2RHZ5	UNII	FDA UNII substance identifier	-	-	openFDA substances
R953O2RHZ5	UNII	FDA UNII substance identifier	-	-	openFDA substances
R953O2RHZ5	UNII	FDA UNII substance identifier	-	-	openFDA substances
R953O2RHZ5	UNII	FDA UNII substance identifier	-	-	openFDA substances
5	unitless	GHS Classification	Inhalation	-	NTP ICE acute inhalation
=4	Unitless	GHS classification	oral	Rat (Female)	NTP ICE acute oral
=4	Unitless	GHS classification	oral	Rat	NTP ICE acute oral
5	unitless	GHS classification	Dermal	Rat	NTP ICE acute dermal
=5	Unitless	GHS classification	oral	Rat (Female)	NTP ICE acute oral
=5	Unitless	GHS classification	oral	Rat (Female)	NTP ICE acute oral
-	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
852.5	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
2093	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
0.14	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
0.84	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
1.03	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
1.34	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
>5.15	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
>2000	mg/kg	LD50	Dermal	Rat	NTP ICE acute dermal

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Pyrithione zinc	236-671-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 3 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1614/19	03-04 March 2020	Safe with restrictions — safe in rinse-off anti-dandruff hair products at 1%; note: subsequently classified CMR 1B and banned	1% in rinse-off hair products	Toxic for reproduction Cat. 1B (subsequently proposed); neurotoxicity (LOAEL established in rat study); CMR classification led to later EU prohibition
SCCS/1593/18	21-22 February 2018	Safe with restrictions — safe for anti-dandruff use at 2% in rinse-off hair products	2% in anti-dandruff rinse-off hair products	Reproductive/developmental toxicity; neurotoxicity (LOAEL established); CMR 1B classification proposed (note: subsequently banned)
SCCS/1512/13	18 June 2014	safe with restrictions	2% hair products (anti-dandruff); 0.5% skin products	Reproductive toxicant (CMR 1B); Article 15 derogation assessed; safe only at specified concentrations for specific uses; not for other applications

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed PYRITHIONE ZINC

ChEMBL Phase

Adverse Events

143

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Zinc pyrithione?

Zinc pyrithione (CAS 13463-41-7) is classified under EU CLP Annex VI as Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H360D; H330; H301; H372; H318; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Zinc pyrithione?

Zinc pyrithione has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include Zinc pyrithione?

Zinc pyrithione appears on 7 regulatory/inventory lists including pharmaceutical, active_ingredient; Europe; Pesticides, active_ingredient; Pesticides, and 4 more. Source: EPA CPDat.

Is Zinc pyrithione used in cosmetics?

Yes, Zinc pyrithione is also indexed as a cosmetic ingredient under the name Zinc Pyrithione. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Zinc pyrithione come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Zinc pyrithione have different safety status in cosmetics vs industrial chemicals?

Zinc pyrithione is prohibited in EU cosmetics at max 0% but has active industrial GHS classifications (H360D, H330, H301, H372, H318, H400, H410).

Is Zinc pyrithione used outside industrial chemicals?

Zinc pyrithione also appears in cosmetics, pharmaceutical databases.