Danger GHS08GHS06GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Zinc pyrithione

Also known as: Zinc, bis[1-(hydroxy-kappaO)-2(1H)-pyridinethionato-.kappa.S2]-, (T-4)-, Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-, Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-, (T-4)-, Zinc, bis(1-(hydroxy-kappaO)-2(1H)-pyridinethionato-kappaS2)-, (T-4)-, Zinc, bis[1-(hydroxy-.kappa.O)-2(1H)-pyridinethionato-.kappa.S2]-, (T-4)- (+14 more)

CAS 13463-41-7

Zinc pyrithione (CAS 13463-41-7) is a chemical substance with GHS signal word Danger; key hazard signal: H360D; H330; H301; H372; H318; H400; H410. Key regulatory status: REACH registered, 35 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Zinc Pyrithione →

SOURCE NOAEL studies
NOAEL studies
100
SOURCE Chemical inventory jurisdictions
Regulatory lists
35
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
Zinc pyrithione
CAS Number
13463-41-7
DTXSID
DTXSID7026314
Molecular Formula
2C5H4NOS.Zn
InChI Key
PICXIOQBANWBIZ-UHFFFAOYSA-N
Monoisotopic Mass
315.931862
Synonyms
Zinc, bis[1-(hydroxy-kappaO)-2(1H)-pyridinethionato-.kappa.S2]-, (T-4)-Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-, (T-4)-Zinc, bis(1-(hydroxy-kappaO)-2(1H)-pyridinethionato-kappaS2)-, (T-4)-Zinc, bis[1-(hydroxy-.kappa.O)-2(1H)-pyridinethionato-.kappa.S2]-, (T-4)-Bis(2-pyridinethiol-1-oxide)zincBis(2-pyridylthio)zinc 1,1'-dioxideBreck One Dandruff ShampooCaswell No. 923EINECS 236-671-3EPA Pesticide Chemical Code 088002Head and Shoulders

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1H360D; H330; H301; H372; H318; H400; H410GHS08; GHS06; GHS05; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
PreservativeSoftener and conditionerPharmaceuticalAnti-dandruffBiocideDegradant/impurity

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 35 records
ListKeywordSource
pharmaceuticalUS International Trade CommissionCPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
inert_ingredient; non_food_use; PesticidesEPACPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
Europe; Personal care - hair styling and care - shampoo-dandruffDanish Environmental Protection AgencyDanish EPA
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
CEDIFDAUnited States Food and Drug Administration (FDA)
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
Europe; Personal care - hair styling and care - shampoo-dandruffDanish Environmental Protection AgencyDanish EPA
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
0.5mg/kg/day-oralratRegulatory source
0.5mg/kg/day-oralratRegulatory source
0.5mg/kg/d-oralratRegulatory source
0.5mg/kg/d-oral-Regulatory source
0.6mg/kg/d-oralratRegulatory source
2mg/kg/d-oral-Regulatory source
5mg/kg bw/d-dermalratRegulatory source
5mg/kg bw/d-dermalratRegulatory source
11mg/kg bw/d-oralratRegulatory source
14--oralratRegulatory source
25mg/kg bw/d-dermal-Regulatory source
50ppm--ratRegulatory source
100mg/kg bw/d-oralmouseRegulatory source
500---ratRegulatory source
500--oralratRegulatory source
1995--oralratRegulatory source
0.246652718uMAC50--NTP ICE endocrine
2.04176096879569uMAC50--NTP ICE endocrine
0.190148851uMACC--NTP ICE endocrine
1.85188882209664uMACC--NTP ICE endocrine
1unitlessEPA ClassificationOcularRabbitNTP ICE eye irritation
4unitlessEPA ClassificationInhalation-NTP ICE acute inhalation
3unitlessEPA classificationDermalRatNTP ICE acute dermal
=3UnitlessEPA classificationoralRatNTP ICE acute oral
=3UnitlessEPA classificationoralRat (Female)NTP ICE acute oral
=3UnitlessEPA classificationoralRat (Female)NTP ICE acute oral
=3UnitlessEPA classificationoralRat (Female)NTP ICE acute oral
3unitlessEPA classificationDermalRabbitNTP ICE skin irritation
3unitlessEPA classificationDermalRabbitNTP ICE skin irritation
4unitlessEPA classificationDermalRabbitNTP ICE skin irritation
4unitlessEPA classificationDermalRabbitNTP ICE skin irritation
R953O2RHZ5UNIIFDA UNII substance identifier--openFDA substances
R953O2RHZ5UNIIFDA UNII substance identifier--openFDA substances
R953O2RHZ5UNIIFDA UNII substance identifier--openFDA substances
R953O2RHZ5UNIIFDA UNII substance identifier--openFDA substances
5unitlessGHS ClassificationInhalation-NTP ICE acute inhalation
=4UnitlessGHS classificationoralRat (Female)NTP ICE acute oral
=4UnitlessGHS classificationoralRatNTP ICE acute oral
5unitlessGHS classificationDermalRatNTP ICE acute dermal
=5UnitlessGHS classificationoralRat (Female)NTP ICE acute oral
=5UnitlessGHS classificationoralRat (Female)NTP ICE acute oral
-%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
852.5ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
2093ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
0.14mg/LLC50Inhalation-NTP ICE acute inhalation
0.84mg/LLC50Inhalation-NTP ICE acute inhalation
1.03mg/LLC50Inhalation-NTP ICE acute inhalation
1.34mg/LLC50Inhalation-NTP ICE acute inhalation
>5.15mg/LLC50Inhalation-NTP ICE acute inhalation
>2000mg/kgLD50DermalRatNTP ICE acute dermal

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredPyrithione zinc236-671-3ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 3 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1614/1903-04 March 2020Safe with restrictions — safe in rinse-off anti-dandruff hair products at 1%; note: subsequently classified CMR 1B and banned1% in rinse-off hair productsToxic for reproduction Cat. 1B (subsequently proposed); neurotoxicity (LOAEL established in rat study); CMR classification led to later EU prohibition
SCCS/1593/1821-22 February 2018Safe with restrictions — safe for anti-dandruff use at 2% in rinse-off hair products2% in anti-dandruff rinse-off hair productsReproductive/developmental toxicity; neurotoxicity (LOAEL established); CMR 1B classification proposed (note: subsequently banned)
SCCS/1512/1318 June 2014safe with restrictions2% hair products (anti-dandruff); 0.5% skin productsReproductive toxicant (CMR 1B); Article 15 derogation assessed; safe only at specified concentrations for specific uses; not for other applications

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
0%
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed PYRITHIONE ZINC
ChEMBL Phase
4
Adverse Events
143
Bioactivity
18
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Zinc pyrithione?

Zinc pyrithione (CAS 13463-41-7) is classified under EU CLP Annex VI as Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H360D; H330; H301; H372; H318; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Zinc pyrithione?

Zinc pyrithione has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include Zinc pyrithione?

Zinc pyrithione appears on 7 regulatory/inventory lists including pharmaceutical, active_ingredient; Europe; Pesticides, active_ingredient; Pesticides, and 4 more. Source: EPA CPDat.

Is Zinc pyrithione used in cosmetics?

Yes, Zinc pyrithione is also indexed as a cosmetic ingredient under the name Zinc Pyrithione. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Zinc pyrithione come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Zinc pyrithione have different safety status in cosmetics vs industrial chemicals?

Zinc pyrithione is prohibited in EU cosmetics at max 0% but has active industrial GHS classifications (H360D, H330, H301, H372, H318, H400, H410).

Is Zinc pyrithione used outside industrial chemicals?

Zinc pyrithione also appears in cosmetics, pharmaceutical databases.