NOAEL Data Cosmetic Ingredient

Butyl lactate

Also known as: 4-03-00-00649, BRN 1721597, Butyl 2-hydroxypropanoate, Butyl alpha-hydroxypropionate, EINECS 205-316-4 (+6 more)

CAS 138-22-7

Butyl lactate (CAS 138-22-7) is a chemical substance. Key regulatory status: 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, OSHA.

View cosmetic safety profile for Butyl Lactate →

Cross-Vertical Regulatory Divergence

Butyl lactate is classified GHS Danger (H227, H335, H315, H336, H318, H319) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

Butyl lactate

CAS Number

138-22-7

DTXSID

DTXSID7042196

Molecular Formula

C7H14O3

InChI Key

MRABAEUHTLLEML-UHFFFAOYSA-N

Monoisotopic Mass

146.094294

Synonyms

4-03-00-00649BRN 1721597Butyl 2-hydroxypropanoateButyl alpha-hydroxypropionateEINECS 205-316-4FEMA No. 22052-Hydroxypropanoic acid butyl esterNSC 6533Butylester kyseliny mlecneUNII-0UI63W814U(+/-)-Butyl lactate

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 3 records

Agency	Metric	Value	ppm	mg/m3	Skin
NIOSH	TWA	5 ppm (25 mg/m³)	5	25	N
ACGIH	TWA	5 ppm [1973]	5	-	N
CAL/OSHA	TWA	5 ppm (25 mg/m³)	5	25	N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records

SolventDeodorizerFlavouring and nutrientFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 13 records

List	Keyword	Source
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
inert_ingredient; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 10 of 10 studies

Value	Unit	Endpoint	Route	Species	Source
0UI63W814U	UNII	FDA UNII substance identifier	-	-	openFDA substances
0UI63W814U	UNII	FDA UNII substance identifier	-	-	openFDA substances
0UI63W814U	UNII	FDA UNII substance identifier	-	-	openFDA substances
0UI63W814U	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
675	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
>5.14	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>5000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
-	unitless	Model Score	-	-	NTP_ICE_endocrine
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 10 of 10 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3183988

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Butyl lactate?

Butyl lactate has 10 NOAEL studies in the database. The lowest reported value is 0UI63W814U UNII. Source: openFDA substances.

What regulatory lists include Butyl lactate?

Butyl lactate appears on 8 regulatory/inventory lists including artificial_saliva; detected; emissions; Europe; Toys and children's products, active_ingredient; Pesticides, IFRA Transparency, and 5 more. Source: EPA CPDat.

What are the occupational exposure limits for Butyl lactate?

Occupational exposure limits for Butyl lactate are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Butyl lactate used in cosmetics?

Yes, Butyl lactate is also indexed as a cosmetic ingredient under the name Butyl Lactate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Butyl lactate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Butyl lactate have different safety status in cosmetics vs industrial chemicals?

Butyl lactate is classified GHS Danger (H227, H335, H315, H336, H318, H319) in the chemicals database but is allowed in EU cosmetics.

Is Butyl lactate used outside industrial chemicals?

Butyl lactate also appears in cosmetics, pharmaceutical, cannabis databases.