What is the NOAEL for Benzyl acetate?
Benzyl acetate has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Benzyl acetate
Also known as: Acetic acid, phenylmethyl ester, Caswell No. 081EA, EINECS 205-399-7, FEMA No. 2135, NCI-C06508 (+11 more)
CAS 140-11-4
Benzyl acetate (CAS 140-11-4) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Benzyl acetate is classified GHS Danger (H412, H227, H315, H319, H336, H370, H372, H373) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
23
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Benzyl acetate
CAS Number
140-11-4
DTXSID
DTXSID0020151
Molecular Formula
C9H10O2
InChI Key
QUKGYYKBILRGFE-UHFFFAOYSA-N
Monoisotopic Mass
150.06808
Synonyms
Acetic acid, phenylmethyl esterCaswell No. 081EAEINECS 205-399-7FEMA No. 2135NCI-C06508UNII-0ECG3V79ZJAcetic acid benzyl esterAcetic acid phenylmethyl esterBenzyl acetate + glycine combinationBenzyl ester of acetic acidBenzylester kyseliny octoveFEMA 2135
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 40, Sup 7, 71 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The vapour is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause unconsciousness. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the kidneys. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
2 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 10 ppm [1990] | 10 | - | N |
| CAL/OSHA | TWA | 10 ppm (61 mg/m³) | 10 | 61 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerProcessing aids not otherwise specifiedFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
23 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; consumer_product; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v26je03 |
| range:0-55 | mg/kg bw/day | ADI | - | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v32je03 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v26je03 |
| range:0-55 | mg/kg bw/day | ADI | - | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v32je03 |
| =25 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v52je14 |
| =25 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v52je14 |
| 15.2 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0ECG3V79ZJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0ECG3V79ZJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0ECG3V79ZJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0ECG3V79ZJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.632 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1860 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 2093 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 4650 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 4966 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 5231 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 5580 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 8504 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 11590 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 16160 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2490 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2490 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2490 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2490 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =35 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =35 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =40 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =40 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =145 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =145 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =500 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =510 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =510 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| >575 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| >575 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =750 | mg/kg bw/day | LOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v37je05 |
| =750 | mg/kg bw/day | LOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v37je05 |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzyl acetate | 205-399-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
aroma_chemical
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
E1501
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Benzyl acetate?
Benzyl acetate appears on 18 regulatory/inventory lists including air; detected; emissions; Europe; Vehicle - car interior - auto air freshener, detected; Europe; Vehicle - car interior, detected; Europe; Personal care - sexual wellness, and 15 more. Source: EPA CPDat.
Is Benzyl acetate a carcinogen according to IARC?
Benzyl acetate is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for Benzyl acetate?
Occupational exposure limits for Benzyl acetate are set by ACGIH, CAL/OSHA. 2 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Benzyl acetate used in cosmetics?
Yes, Benzyl acetate is also indexed as a cosmetic ingredient under the name Benzyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Benzyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Benzyl acetate have different safety status in cosmetics vs industrial chemicals?
Benzyl acetate is classified GHS Danger (H412, H227, H315, H319, H336, H370, H372, H373) in the chemicals database but is allowed in EU cosmetics.
Is Benzyl acetate used outside industrial chemicals?
Benzyl acetate also appears in cosmetics, pharmaceutical, cannabis databases.