Danger GHS07GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

Ethanolamine

Also known as: Monoethanolamine, 2-Aminoethanol, Caswell No. 426, EINECS 205-483-3, EPA Pesticide Chemical Code 011601 (+15 more)

CAS 141-43-5

Ethanolamine (CAS 141-43-5) is a chemical substance with GHS signal word Danger; key hazard signal: H332; H312; H302; H314. Key regulatory status: REACH registered, 27 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Monoethanolamine (MEA) →

SOURCE NOAEL studies
NOAEL studies
54
SOURCE Chemical inventory jurisdictions
Regulatory lists
27
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
Ethanolamine
CAS Number
141-43-5
Molecular Formula
C2H7NO
InChI Key
HZAXFHJVJLSVMW-UHFFFAOYSA-N
Monoisotopic Mass
61.052764
Synonyms
Monoethanolamine2-AminoethanolCaswell No. 426EINECS 205-483-3EPA Pesticide Chemical Code 011601beta-HydroxyethylamineThiofaco M-50USAF EK-15972-AminoetanoloEtanolaminaKolaminUNII-5KV86114PT

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1BH332; H312; H302; H314GHS07; GHS05Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsHarmful if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life with long lasting effects
Short-term EffectsThe substance is corrosive to the skin and eyes. Corrosive on ingestion. The vapour is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in lowering of consciousness.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records
AgencyMetricValueppmmg/m3Skin
OSHATWA3 ppm (6 mg/m³)36N
NIOSHTWA3 ppm (8 mg/m³)38N
NIOSHSTEL6 ppm (15 mg/m³)615N
CAL/OSHATWA3 ppm (8 mg/m³)38N
CAL/OSHASTEL6 ppm (15 mg/m³)615N
NIOSHIDLH30 ppm30--

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
Surfactant (surface active agent)pH regulating agentSolventEmulsifierCorrosion inhibitorPharmaceuticalSurface modifierIntermediateCleaning agentDefoamerPreservativeFragranceProcessing aids not otherwise specified

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 27 records
ListKeywordSource
active_ingredient; animal_products; Europe; pharmaceutical; residueEUCPCat
Cleaning products and household care - oven - oven cleaner; EuropeDanish Environmental Protection AgencyDanish EPA
Europe; Specialty occupational productsDanish Environmental Protection AgencyDanish EPA
Europe; Specialty occupational productsDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
pharmaceuticalUS International Trade CommissionCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
SCIL (9/2019)USEPASafer Chemical Ingredients List
Canada; pharmaceuticalDrugBankDrugBank
Cleaning products and household care - laundry and fabric treatment - laundry detergent; EuropeDanish EPADanish EPA
Cleaning products and household care; EuropeDanish EPADanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
CEDIFDAUnited States Food and Drug Administration (FDA)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
fracking; waterNY Department of ConservationCPCat
pharmaceuticalUS International Trade CommissionCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 54 studies
ValueUnitEndpointRouteSpeciesSource
22.09minBreakthrough TimeDermal-NTP ICE skin irritation
23.88minBreakthrough TimeDermal-NTP ICE skin irritation
=0.51mg/m3DNEL localinhalationHumanToxValDB GESTIS DNEL
=1mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
23.3unitlessDraize rabbit irritation scoreOcularRabbitNTP ICE eye irritation
3unitlessEPA ClassificationOcularRabbitNTP ICE eye irritation
5KV86114PTUNIIFDA UNII substance identifier--openFDA substances
1unitlessGHS ClassificationOcularRabbitNTP ICE eye irritation
1unitlessGHS classificationDermalRabbitNTP ICE skin irritation
0.36%/secIntensityOcular-NTP ICE eye irritation
>1.3mg/LLC50Inhalation-NTP ICE acute inhalation
=1720mg/kg bwLD50oralRatNTP ICE acute oral
=2050mg/kg bwLD50oralRatNTP ICE acute oral
=2740mg/kg bwLD50oralRatNTP ICE acute oral
=3320mg/kg bwLD50oralRatNTP ICE acute oral
=1.020e+4mg/kg bwLD50oralRatNTP ICE acute oral
=7.495e+4mg/m3LELinhalationHumanToxValDB DOE Protective Action Criteria
=5ppmLOAEL-RatToxValDB TX TCEQ
=12.49mg/m3LOAELinhalationRatToxValDB EU SCOEL
450mg/kg bw/dayLOAELoralratCOSMOS DB
0sLag timeOcular-NTP ICE eye irritation
0unitlessModel Score--NTP ICE endocrine
=10mg/kg bw/dNOAELoralratCIR Safety Assessment
=29.98mg/m3NOAELinhalationDogToxValDB TX TCEQ
40mg/kg bw/dayNOAELoralratCOSMOS DB
50mg/kg bw/dayNOAELoralratCOSMOS DB
=75mg/kg bw/dayNOAELdermalRabbitECHA
=75mg/kg/dNOAEL-ratCIR Safety Assessment
>=97.5mg/kg bw/dayNOAELoralDogECHA
120mg/kg bw/dayNOAELoralratCOSMOS DB
=120mg/kg/dNOAELoralratCIR Safety Assessment
=225mg/kg bw/dayNOAELdermalRatECHA
=300mg/kg bw/dayNOAELoralRatECHA
=300mg/kg bw/dNOAELoralratCIR Safety Assessment
=320mg/kg bw/dayNOAELoralRatECHA
=450mg/kg bw/dayNOAELoralRatECHA
500mg/kg bw/dayNOAELoralratCOSMOS DB
850mg/kg bw/dayNOAELoralmouseCOSMOS DB
=1000mg/kg bw/dNOAELoralratCIR Safety Assessment
65.4%Plateau levelOcular-NTP ICE eye irritation
10.8%Viability (240 minutes)Dermal-NTP ICE skin irritation
20.2%Viability (240 minutes)Dermal-NTP ICE skin irritation
20.8%Viability (240 minutes)Dermal-NTP ICE skin irritation
66.2%Viability (3 minutes)Dermal-NTP ICE skin irritation
78.7%Viability (3 minutes)Dermal-NTP ICE skin irritation
105.7%Viability (3 minutes)Dermal-NTP ICE skin irritation
40.3%Viability (60 minutes)Dermal-NTP ICE skin irritation
52.3%Viability (60 minutes)Dermal-NTP ICE skin irritation
67.4%Viability (60 minutes)Dermal-NTP ICE skin irritation
10mg/kg bw/ddevelopmental toxicityoralratRegulatory source

Showing 50 of 54 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered2-aminoethanol205-483-3ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.5% as leave-on cosmetic; higher concentrations permitted in rinse-off hair dye and bleach products
Category
ph-adjuster
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed MONOETHANOLAMINE
ChEMBL Phase
2
Adverse Events
2
Bioactivity
3
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Ethanolamine?

Ethanolamine (CAS 141-43-5) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B with signal word Danger. Hazard statements: H332; H312; H302; H314. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ethanolamine?

Ethanolamine has 54 NOAEL studies in the database. The lowest reported value is 0 s via Ocular. Source: NTP ICE eye irritation.

What regulatory lists include Ethanolamine?

Ethanolamine appears on 14 regulatory/inventory lists including active_ingredient; animal_products; Europe; pharmaceutical; residue, Cleaning products and household care - oven - oven cleaner; Europe, Europe; Specialty occupational products, and 11 more. Source: EPA CPDat.

What are the occupational exposure limits for Ethanolamine?

Occupational exposure limits for Ethanolamine are set by OSHA, NIOSH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Ethanolamine used in cosmetics?

Yes, Ethanolamine is also indexed as a cosmetic ingredient under the name Monoethanolamine (MEA). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ethanolamine come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Ethanolamine have different safety status in cosmetics vs industrial chemicals?

Ethanolamine is classified GHS Danger (H332, H312, H302, H314) in the chemicals database but is restricted in EU cosmetics at max 0.5% as leave-on cosmetic; higher concentrations permitted in rinse-off hair dye and bleach products.

Is Ethanolamine used outside industrial chemicals?

Ethanolamine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.