What is the NOAEL for Hexadecanoic acid, 1-methylethyl ester?
Hexadecanoic acid, 1-methylethyl ester has 14 NOAEL studies in the database. The lowest reported value is 25.85 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexadecanoic acid, 1-methylethyl ester
Also known as: 4-02-00-01167, BRN 1786567, EINECS 205-571-1, Plymouth IPP, UNII-8CRQ2TH63M (+15 more)
CAS 142-91-6
Hexadecanoic acid, 1-methylethyl ester (CAS 142-91-6) is a chemical substance. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
14
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Hexadecanoic acid, 1-methylethyl ester
CAS Number
142-91-6
DTXSID
DTXSID9027104
Molecular Formula
C19H38O2
InChI Key
XUGNVMKQXJXZCD-UHFFFAOYSA-N
Monoisotopic Mass
298.28718
Synonyms
4-02-00-01167BRN 1786567EINECS 205-571-1Plymouth IPPUNII-8CRQ2TH63M1-Methylethyl ester1-methylethyl hexandecanoate2-Propyl hexadecanoateDeltylEmcol-ipEstol 103Hexadecanoic acid isopropyl esterHexadecanoic acid, isopropyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Softener and conditionerDeodorizerFragranceBinderSolventAnti-static agentFlavouring and nutrientLubricating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
14 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =25.85 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8CRQ2TH63M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8CRQ2TH63M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8CRQ2TH63M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8CRQ2TH63M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| - | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 97.4 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 103.6 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 104.32 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 104.83 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 122.3 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isopropyl palmitate | 205-571-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ISOPROPYL PALMITATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Hexadecanoic acid, 1-methylethyl ester?
Hexadecanoic acid, 1-methylethyl ester appears on 13 regulatory/inventory lists including Europe, inert_ingredient; non_food_use; Pesticides, detected; Europe; Other direct contact consumer goods, and 10 more. Source: EPA CPDat.
Is Hexadecanoic acid, 1-methylethyl ester used in cosmetics?
Yes, Hexadecanoic acid, 1-methylethyl ester is also indexed as a cosmetic ingredient under the name Isopropyl Palmitate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexadecanoic acid, 1-methylethyl ester come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Hexadecanoic acid, 1-methylethyl ester used outside industrial chemicals?
Hexadecanoic acid, 1-methylethyl ester also appears in cosmetics, pharmaceutical, cannabis databases.