What is the NOAEL for Zeaxanthin?
Zeaxanthin has 9 NOAEL studies in the database. The lowest reported value is 0.75 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
Cosmetic Ingredient
Zeaxanthin
Also known as: EINECS 205-636-4, 3R 3'R Zeaxanthin, 3R,3'R-Zeaxanthin, UNII-CV0IB81ORO, meso-Zeaxanthin (+6 more)
CAS 144-68-3
Zeaxanthin (CAS 144-68-3) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Zeaxanthin
CAS Number
144-68-3
DTXSID
DTXSID5046807
Molecular Formula
C40H56O2
InChI Key
JKQXZKUSFCKOGQ-QAYBQHTQSA-N
Monoisotopic Mass
568.428031
Synonyms
EINECS 205-636-43R 3'R Zeaxanthin3R,3'R-ZeaxanthinUNII-CV0IB81OROmeso-Zeaxanthinbeta-Carotene-3,3'-diol(1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl]-3,5,5-trimethylcyclohex-3-en-1-ol(3R,3'R)-Zeaxanthin(3R,3'R)-dihydroxy-beta,beta-caroteneall-trans-beta-carotene-3,3'-diolbeta,beta-carotene-3,3'-diol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Antioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.75 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.75 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| CV0IB81ORO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CV0IB81ORO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CV0IB81ORO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CV0IB81ORO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =150 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =150 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 9 of 9 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ZEAXANTHIN
ChEMBL Phase
3
Adverse Events
185
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
FDA GRAS: FDA has no questions; some uses may require a color additive listing
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Zeaxanthin?
Zeaxanthin appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Zeaxanthin used in cosmetics?
Yes, Zeaxanthin is also indexed as a cosmetic ingredient under the name Zeaxanthin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Zeaxanthin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Zeaxanthin used outside industrial chemicals?
Zeaxanthin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.