Warning GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]-

CAS 146925-83-9

1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]- (CAS 146925-83-9) is a chemical substance with GHS signal word Warning; key hazard signal: H400; H410. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, AICIS, ECHA REACH.

View cosmetic safety profile for Isostearyl Glyceryl Pentaerythrityl Ether →

SOURCE noael studies public
NOAEL studies
4
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 3 fields
Name
1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]-
CAS Number
146925-83-9
DTXSID
DTXSID301074805

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Aquatic Acute 1; Aquatic Chronic 1H400; H410GHS09Warning

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies
ValueUnitEndpointRouteSpeciesSource
3X85950A89UNIIFDA UNII substance identifier--openFDA substances
3X85950A89UNIIFDA UNII substance identifier--openFDA substances
3X85950A89UNIIFDA UNII substance identifier--openFDA substances
3X85950A89UNIIFDA UNII substance identifier--openFDA substances

Showing 4 of 4 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]-1,3-propanediol416-380-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]-?

1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]- (CAS 146925-83-9) is classified under EU CLP Annex VI as Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]-?

1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]- has 4 NOAEL studies in the database. The lowest reported value is 3X85950A89 UNII. Source: openFDA substances.

Is 1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]- used in cosmetics?

Yes, 1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]- is also indexed as a cosmetic ingredient under the name Isostearyl Glyceryl Pentaerythrityl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]- come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]- used outside industrial chemicals?

1,3-Propanediol, 2-(hydroxymethyl)-2-[[2-hydroxy-3-(isooctadecyloxy)propoxy]methyl]- also appears in cosmetics databases.