What is the NOAEL for Talc?
Talc has 22 NOAEL studies in the database. The lowest reported value is 2.16 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
IARC Group 2A
REACH Registered
Cosmetic Ingredient
Talc
Also known as: Talc (Mg3H2(SiO3)4), Alpine talc USP, bc 127, EINECS 238-877-9, Finntalc C10, Finntalc M05 (+15 more)
CAS 14807-96-6
Talc (CAS 14807-96-6) is a chemical substance; key hazard signal: IARC Group 2A. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA.
SOURCE
noael studies public
NOAEL studies
22
SOURCE
chemical inventory jurisdictions
Regulatory lists
14
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Talc
CAS Number
14807-96-6
DTXSID
DTXSID5032109
Synonyms
Talc (Mg3H2(SiO3)4)Alpine talc USP, bc 127EINECS 238-877-9Finntalc C10Finntalc M05Finntalc M15Finntalc P40Hydrous magnesium silicateLo Micron talc USP, bc 2755Magnesium silicate, hydrousMicro Ace K1Micro Ace L1
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2A | Probably carcinogenic | 2024 | 42, Sup 7, 93, 136 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | May cause damage to lungs through prolonged or repeated exposure if inhaled |
| Short-term Effects | May cause mechanical irritation to the eyes and respiratory tract. |
| Long-term Effects | The substance may have effects on the lungs. This may result in pneumoconiosis. See Notes. |
| Routes of Exposure | Exposure mainly occurs via inhalation. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
6 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | Use Asbestos TLV® | - | - | - |
| OSHA | TWA | 20 mppcf | - | - | N |
| NIOSH | TWA | 2 mg/m³ (resp) | - | 2 | N |
| ACGIH | TWA | 2 mg/m³ (respirable particulate matter) [2009] | - | 2 | N |
| CAL/OSHA | TWA | 2 mg/m³ (respirable dust) | - | 2 | N |
| NIOSH | IDLH | 1000 mg/m³ | - | 1000 | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
AbrasiveAbsorbentAnti-caking agentHumectantDeodorizerOpaciferFillerProcessing aids not otherwise specifiedAnti-adhesive/cohesive
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
14 records
| List | Keyword | Source |
|---|---|---|
| fracking; water | NY Department of Conservation | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3.6 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =2.16 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 7SEV7J4R1U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7SEV7J4R1U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7SEV7J4R1U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7SEV7J4R1U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2A | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2A | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2A | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =25 | mg/kg bw/day | LEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| 900 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 1200 | mg/kg bw/day | NOAEL | oral | syrian hamster | COSMOS_DB |
| 1600 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| <=6000 | mg hr/m3 | NOEL | inhalation | Hamster | ToxValDB_ECHA_IUCLID |
| <=6000 | mg hr/m3 | NOEL | inhalation: aerosol | hamster, Syrian (other:; male/female) | FDA_Toxicity_696e01d2-2f8e-4bee-8916-7e260c90e14d_dossier.i6z |
| <=6000 | mg hr/m3 | NOEL | inhalation: aerosol | hamster, Syrian (other:; male/female) | FDA_Toxicity_696e01d2-2f8e-4bee-8916-7e260c90e14d_dossier.i6z |
| <=6000 | mg hr/m3 | NOEL | inhalation: aerosol | hamster, Syrian (other:; male/female) | FDA_Toxicity_696e01d2-2f8e-4bee-8916-7e260c90e14d_dossier.i6z |
| <=6000 | mg hr/m3 | NOEL | inhalation: aerosol | hamster, Syrian (other:; male/female) | FDA_Toxicity_696e01d2-2f8e-4bee-8916-7e260c90e14d_dossier.i6z |
| 18 | mg/m3/day | POLY-3 lowest dose | Inhalation | Rat | NTP_ICE_cancer |
| 18 | mg/m3 | Top dose | Inhalation | Rat | NTP_ICE_cancer |
Showing 22 of 22 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Talc (Mg3H2(SiO3)4) | 238-877-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
No specific EU concentration limit. Heavy metal impurities in talc raw material must comply with BVL/BfR trace limits: lead ≤ 10 ppm (general), arsenic ≤ 2.5 ppm, nickel ≤ 10 ppm (soluble), cadmium ≤ 0.1 ppm. EU requires documentation of technically unavoidable heavy metal impurities in the PIF. Nano form (particle < 100 nm) would require pre-market notification.
Category
mineral
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
talc
ChEMBL Phase
Not listed
Adverse Events
13
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E553a — ADI: NOT SPECIFIED mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Talc?
Talc appears on 13 regulatory/inventory lists including fracking; water, drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; Pesticides, and 10 more. Source: EPA CPDat.
Is Talc a carcinogen according to IARC?
Talc is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 2024). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for Talc?
Occupational exposure limits for Talc are set by ACGIH, OSHA, NIOSH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Talc used in cosmetics?
Yes, Talc is also indexed as a cosmetic ingredient under the name Talc. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Talc come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Talc used outside industrial chemicals?
Talc also appears in cosmetics, pharmaceutical, food safety, cannabis databases.